{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:26:23Z","timestamp":1765877183988,"version":"3.48.0"},"reference-count":38,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,2,20]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?ID=CRD42019100745\" ext-link-type=\"uri\">CRD42019100745<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-025640","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T19:35:21Z","timestamp":1554406521000},"page":"e025640","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review"],"prefix":"10.1136","volume":"9","author":[{"given":"Melanie M","family":"Ashton","sequence":"first","affiliation":[{"name":"IMPACT Strategic Resarch Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia"},{"name":"Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, Victoria, Australia"},{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[{"name":"IMPACT Strategic Resarch Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia"},{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia"},{"name":"Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia"},{"name":"Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia"},{"name":"Centre of Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee H","family":"Ng","sequence":"additional","affiliation":[{"name":"Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Hopwood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia"},{"name":"Professorial Psychiatry Unit, The Albert Road Clinic, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1656-2775","authenticated-orcid":false,"given":"Bianca","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"IMPACT Strategic Resarch Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana J","family":"Williams","sequence":"additional","affiliation":[{"name":"IMPACT Strategic Resarch Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Sarris","sequence":"additional","affiliation":[{"name":"Professorial Unit, The Melbourne Clinic, Department of Psychiatry, University of Melbourne, Richmond, Victoria, Australia"},{"name":"NICM Health Research Institute, Western Sydney University, Westmead, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia M","family":"Dean","sequence":"additional","affiliation":[{"name":"IMPACT Strategic Resarch Centre, School of Medicine, Deakin University, Geelong, Victoria, Australia"},{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia"},{"name":"Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"2025121601220212000_9.4.e025640.1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (APA). 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