{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:03:24Z","timestamp":1784127804037,"version":"3.55.0"},"reference-count":13,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2018,12,18]]},"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Use of albumin therapy is recommended for management of disease complications in cirrhosis. The effectiveness of albumin to prevent specific disease complications and death, however, is less clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will search Medline (Ovid), Embase (Ovid), Cochrane Hepato-Biliary Controlled Trials Register and Cochrane Central Register of Controlled Trials for published reports on randomised controlled trials and observational studies on the effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in cirrhotic patients. Two independent reviewers will screen the studies for eligibility, extract data and assess risk of bias and quality of evidence using Grading of Recommendations Assessment, Development and Evaluation system. Random effects meta-analyses will be performed when appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>As no primary data will be collected, a formal ethical approval is not required. We plan to publish the results of this study in a relevant peer-reviewed journal or journals. The study results may also be presented at relevant conferences and meetings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42018100798.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-025664","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T23:09:58Z","timestamp":1548889798000},"page":"e025664","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of intravenous albumin therapy to prevent spontaneous bacterial peritonitis, renal dysfunction and death in adults with cirrhosis: a protocol for a systematic review"],"prefix":"10.1136","volume":"9","author":[{"given":"Suvi","family":"H\u00e4rm\u00e4l\u00e4","sequence":"first","affiliation":[{"name":"Institute of Health Informatics, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Parisinos","sequence":"additional","affiliation":[{"name":"Institute of Health Informatics, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ryan","sequence":"additional","affiliation":[{"name":"Royal Free London NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Division of Medicine, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"2025121400113046000_9.1.e025664.1","unstructured":"GBD. Disease and injury incidence and prevalence collaborators\u00a0global burden of disease results tool. 2016 http:\/\/ghdx.healthdata.org\/gbd-results-tool."},{"key":"2025121400113046000_9.1.e025664.2","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.27322","article-title":"Posttranscriptional changes of serum albumin: clinical and prognostic significance in hospitalized patients with cirrhosis","volume":"60","author":"Domenicali","year":"2014","journal-title":"Hepatology"},{"key":"2025121400113046000_9.1.e025664.3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL clinical practice guidelines for the management of patients with decompensated cirrhosis","volume":"69","author":"European Association for the Study of the Liver","year":"2018","journal-title":"J Hepatol"},{"key":"2025121400113046000_9.1.e025664.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.11.007"},{"key":"2025121400113046000_9.1.e025664.5","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/592745"},{"key":"2025121400113046000_9.1.e025664.6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/jgh.13421","article-title":"Insufficient evidence of benefit regarding mortality due to albumin substitution in HCC-free cirrhotic patients undergoing large volume paracentesis","volume":"32","author":"K\u00fctting","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"2025121400113046000_9.1.e025664.7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24786"},{"key":"2025121400113046000_9.1.e025664.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"2025121400113046000_9.1.e025664.9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"2025121400113046000_9.1.e025664.10","unstructured":"The Cochrane Collaboration. 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The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (Accessed 25 Jul 2018)."},{"key":"2025121400113046000_9.1.e025664.12","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c365","article-title":"The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews","volume":"340","author":"Kirkham","year":"2010","journal-title":"BMJ"},{"key":"2025121400113046000_9.1.e025664.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-025664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:11:38Z","timestamp":1765699898000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-025664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,29]]},"published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1136\/bmjopen-2018-025664"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-025664","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}