{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:40:12Z","timestamp":1775187612708,"version":"3.50.1"},"reference-count":35,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,2,28]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was performed to analyse anaesthesia-related complications and side effects in patients undergoing transcatheter aortic valve implantation (TAVI) under general anaesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The study was performed as a single-centre study in a hospital of tertiary care in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>All 853 patients, who underwent TAVI at the Universit\u00e4tsklinikum Regensburg between January 2009 and July 2015, were included. 52.5% were female patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>We gathered information, such as recent illness, vital parameters and medication administered during the intervention and postoperatively for 12 hours. We analysed all anaesthesia-related complications and anaesthesia-related side effects that occurred during the intervention and entire hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed all 853 TAVI procedures. The mean patient age was 79 \u00b1 6 years. In 99.5% of cases, we used volatile-based anaesthesia. 2.8% (n=24; transfemoral (TF): n=19 [3.8%]; transapical (TA): n=5 [1.4%]) of all cases suffered from anaesthesia-related complications. 819 (TF: n=447; TA: n=372) anaesthesia-related side effects occurred in 586 (68.7%, TF: n=325 [64.2%], TA: n=261 [75.2%]) patients. Neither the complications nor the side effects had any serious consequences. Intraoperative hypothermia in 44% of cases (TF: n=202 [39.9%]; TA: n=173 [49.9%]) and postoperative nausea and vomiting in 27% (n=232; TF: n=131 [25.9%], TA: n=101 [29.1%]) of cases were the most common anaesthesia-related side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, serious anaesthesia-related complications were rarely seen, and non-critical anaesthesia-related side effects could have been avoided through consistent prophylaxis and management. Therefore, despite their high anaesthetic risk, general anaesthesia is justifiable in patients who underwent TAVI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-025825","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T04:35:56Z","timestamp":1556771756000},"page":"e025825","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Anaesthesia-related complications and side-effects in TAVI: a retrospective study in Germany"],"prefix":"10.1136","volume":"9","author":[{"given":"Sophia","family":"Goldfuss","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"W\u00fcrschinger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Bitzinger","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Holzamer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Camboni","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Sinner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"York Alexander","family":"Zausig","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Universitatsklinikum Regensburg, Regensburg, Germany"},{"name":"Department of Anaesthesiology and Operative Intensive Care Medicine, Klinikum Aschaffenburg, Aschaffenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,1]]},"reference":[{"key":"2025120519373023000_9.4.e025825.1","unstructured":"Statistisches Bundesamt. 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