{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:17:13Z","timestamp":1790666233532,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,3,29]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study was to estimate the annual incidence of Lyme disease (LD) in the UK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a retrospective descriptive cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Study data were extracted from the Clinical Practice Research Datalink (CPRD), a primary care database covering about 8% of the population in the UK in 658 primary care practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Cohort of 8.4 million individuals registered with general practitioners with 52.4 million person-years of observation between 1 January 2001 and 31 December 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>LD was identified from recorded medical codes, notes indicating LD, laboratory tests and use of specific antibiotics. Annual incidence rates and the estimated total number of LD cases were calculated separately for each UK region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of cases of LD increased rapidly over the years 2001 to 2012, leading to an estimated incidence rate of 12.1 (95% CI 11.1 to 13.2) per 100\u2009000 individuals per year and a UK total of 7738 LD cases in 2012. LD was detected in every UK region with highest incidence rates and largest number of cases in Scotland followed by South West and South England. If the number of cases has continued to rise since the end of the study period, then the number in the UK in 2019 could be over 8000.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:bold>Conclusions<\/jats:bold>\n                    <\/jats:title>\n                    <jats:p>The incidence of LD is about threefold higher than previously estimated, and people are at risk throughout the UK. These results should lead to increased awareness of the need for preventive measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>This study was approved by the Independent Scientific Advisory Committee for CPRD research (Protocol number 13_210R).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-025916","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:09:02Z","timestamp":1564531742000},"page":"e025916","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Incidence of Lyme disease in the UK: a population-based cohort study"],"prefix":"10.1136","volume":"9","author":[{"given":"Victoria","family":"Cairns","sequence":"first","affiliation":[{"name":"Retired, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Wallenhorst","sequence":"additional","affiliation":[{"name":"Epidemiology, Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Rietbrock","sequence":"additional","affiliation":[{"name":"Epidemiology, Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Martinez","sequence":"additional","affiliation":[{"name":"Epidemiology, Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"2025121400320476000_9.7.e025916.1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu397"},{"key":"2025121400320476000_9.7.e025916.2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2109.150417"},{"key":"2025121400320476000_9.7.e025916.3","unstructured":"Lindgren E , Jaenson TG . 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Lyme disease 2018. 2018 https:\/\/www.nice.org.uk\/guidance\/ng95 (Accessed 22 Oct 2018)."},{"key":"2025121400320476000_9.7.e025916.8","first-page":"827","article-title":"Data resource profile: Clinical Practice Research Datalink (CPRD)","volume":"44","author":"Herrett","year":"2015","journal-title":"Int J"},{"key":"2025121400320476000_9.7.e025916.9","unstructured":"Office for National Statistics. Population Estimates for UK, England and Wales, Scotland and Northern Ireland: mid-2015. https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/populationandmigration\/populationestimates\/datasets\/populationestimatesforukenglandandwalesscotlandandnorthernireland (Assessed 2 Aug 2018)."},{"key":"2025121400320476000_9.7.e025916.10","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S122313"},{"key":"2025121400320476000_9.7.e025916.11","doi-asserted-by":"crossref","unstructured":"Tulloch JBT , Russel JBT , Halsby JBT , et al . 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