{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:59:13Z","timestamp":1790621953993,"version":"4.1.0"},"reference-count":51,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,5,2]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Despite considerable improvements, 5-year survival rates for colon cancer in the UK remain poor when compared with other socioeconomically similar countries. Variation in 5-year survival can be partly explained by higher rates of death within 3\u2009months of diagnosis in the UK. This study investigated the characteristics of patients who died within 3\u2009months of a diagnosis of colon cancer with the aim of identifying specific patient factors that can be addressed or accounted for to improve survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective case\u2013control study design was applied with matching on age, sex and year diagnosed. Patient, disease, clinical and service characteristics of patients diagnosed with colon cancer in a UK region (2005\u20132010) who survived less than 3\u2009months from diagnosis (cases) were compared with patients who survived between 6 and 36 months (controls). Patient and clinical data were sourced from general practice notes and hospital databases 1\u20133 years prediagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Being older (aged \u226578 years) and living in deprivation quintile 5 (OR=2.64, 95% CI 1.15 to 6.06), being unmarried and living alone (OR=1.64, 95% CI 1.07 to 2.50), being underweight compared with normal weight or obese (OR=3.99, 95% CI 1.14 to 14.0), and being older and living in a rural as opposed to urban area (OR=1.96, 95% CI 1.21 to 3.17) were all independent predictors of early death from colon cancer. Missing information was also associated with early death, including unknown stage, histological type and marital\/accommodation status after accounting for other factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several factors typically associated with social isolation were a recurring theme in patients who died early from colon cancer. This association is unexplained by clinical or diagnostic pathway characteristics. Socially isolated patients are a key target group to improve outcomes of the worst surviving patients, but further investigation is required to determine if being isolated itself is actually a cause of early death from colon cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-026057","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T05:25:27Z","timestamp":1561008327000},"page":"e026057","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of an early death in patients diagnosed with colon cancer: a retrospective case\u2013control study in the UK"],"prefix":"10.1136","volume":"9","author":[{"given":"Conan","family":"Donnelly","sequence":"first","affiliation":[{"name":"University of Cork, National Cancer Registry Ireland, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Hart","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Biomedical Sciences, Queen\u2019s University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-2154","authenticated-orcid":false,"given":"Alan David","family":"McCrorie","sequence":"additional","affiliation":[{"name":"Centre for Cancer Research and Cell Biology, Queen\u2019s University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Centre for Public Health, Queen\u2019s University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Anderson","sequence":"additional","affiliation":[{"name":"Centre for Public Health, Queen\u2019s University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ranaghan","sequence":"additional","affiliation":[{"name":"Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gavin","sequence":"additional","affiliation":[{"name":"N Ireland Cancer Registry, Queen\u2019s University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"2025121510492269000_9.6.e026057.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62231-3"},{"key":"2025121510492269000_9.6.e026057.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70546-1"},{"key":"2025121510492269000_9.6.e026057.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.229575"},{"key":"2025121510492269000_9.6.e026057.4","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/bjc.2012.585","article-title":"Early mortality from colorectal cancer in England: a retrospective observational study of the factors associated with death in the first year after diagnosis","volume":"108","author":"Downing","year":"2013","journal-title":"Br J Cancer"},{"key":"2025121510492269000_9.6.e026057.5","unstructured":"Northern Ireland Cancer Registry. 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