{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:15:09Z","timestamp":1792516509769,"version":"4.5.0"},"reference-count":29,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,4,5]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Critical and chronic illness in youth such as diabetes can lead to impaired mental health. Despite the potentially traumatic and life-threatening nature of venous thromboembolism (VTE), the long-term mental health of adolescents and young adults with VTE is unclear. We compared the long-term mental health of adolescents and young adults with VTE versus adolescents and young adults with insulin-dependent diabetes mellitus (IDDM) using psychotropic drug purchase as proxy for mental health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Nationwide registry-based cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Denmark 1997\u20132015.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>All patients aged 13\u201333 years with an incident diagnosis of VTE (n=5065) or IDDM (n=6609).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Exposure<\/jats:title>\n                  <jats:p>First time primary hospital diagnosis of VTE or IDDM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome measures<\/jats:title>\n                  <jats:p>Adjusted absolute risk and risk difference at 1 and 5 years follow-up for first psychotropic drug purchase comparing patients with VTE and patients with IDDM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The absolute 1\u2009year risk of psychotropic drug use was 6.2% among VTE patients versus 3.6% among patients with IDDM, at 5 years this was 19.3%\u201314.7%, respectively. After adjusting for the effect of sex, age and risk factors for VTE this corresponded to a 1\u2009year risk differences of 1.9% (95 % CI 0.1% to 3.3%). At 5\u2009years follow-up the risk difference was 1.9% (95% CI 0.5% to 3.3%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>One-fifth of adolescents and young adults with incident VTE had claimed a prescription for a psychotropic drug within 5 years, a risk comparable to that of young patients with IDDM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-026159","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T06:25:44Z","timestamp":1557901544000},"page":"e026159","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Psychotropic drug use following venous thromboembolism versus diabetes mellitus in adolescence or young adulthood: a Danish nationwide cohort study"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-3069","authenticated-orcid":false,"given":"Anette Arbjerg","family":"H\u00f8jen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Melgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre A.","family":"Lane","sequence":"additional","affiliation":[{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Elgaard","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Clinical Nursing Research Unit, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Zachary","family":"Goldhaber","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Cardiovascular Medicine Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben Bjerregaard","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"2025101811060681000_9.5.e026159.1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12363"},{"key":"2025101811060681000_9.5.e026159.2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b13e3181908bf4"},{"key":"2025101811060681000_9.5.e026159.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02310.x"},{"key":"2025101811060681000_9.5.e026159.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61904-1"},{"key":"2025101811060681000_9.5.e026159.5","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-09-0793"},{"key":"2025101811060681000_9.5.e026159.6","doi-asserted-by":"publisher","DOI":"10.1097\/00012272-200009000-00006"},{"key":"2025101811060681000_9.5.e026159.7","unstructured":"Sigelman CK , Rider EA . 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