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In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children\u2019s outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1\u2009year 26 follow-up are underway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN12617001599369<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-026276","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T05:56:52Z","timestamp":1559023012000},"page":"e026276","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Western Australian pregnancy cohort (Raine) Study: Generation 1"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0348-9556","authenticated-orcid":false,"given":"Manon L","family":"Dontje","sequence":"first","affiliation":[{"name":"School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eastwood","sequence":"additional","affiliation":[{"name":"Centre for Sleep Science, School of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Straker","sequence":"additional","affiliation":[{"name":"School of Physiotherapy and Exercise Science, Curtin University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"2025121410294054000_9.5.e026276.1","unstructured":"Newnham JP , Reid SE . A randomised controlled trial of doppler waveform analysis in obstetrics. 1987."},{"key":"2025121410294054000_9.5.e026276.2","unstructured":"Newnham JP , Michael CA , Landau LI , et al . The Origins of Disease in the Fetus, the Child and the Young Adult: A Western Australian Pregnancy Cohort Study. 1988."},{"key":"2025121410294054000_9.5.e026276.3","first-page":"1384","article-title":"Cohort Profile: The Western Australian Pregnancy Cohort (Raine) Study-Generation 2","volume":"46","author":"Straker","year":"2017","journal-title":"Int J Epidemiol"},{"key":"2025121410294054000_9.5.e026276.4","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91944-H"},{"key":"2025121410294054000_9.5.e026276.5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx429"},{"key":"2025121410294054000_9.5.e026276.6","doi-asserted-by":"crossref","unstructured":"Ayonrinde OT , Adams LA , Mori TA , et al . Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents. 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