{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:29:45Z","timestamp":1740162585260,"version":"3.37.3"},"reference-count":47,"publisher":"BMJ","issue":"6","funder":[{"name":"Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital"},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00d6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,6,7]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Moisture damage (MD) exposure at work has been shown to increase the risk of new onset asthma and exacerbation of asthma. However, most of the studies in this field have been questionnaire studies. A small proportion of MD-exposed workers are diagnosed with asthma. Many patients with MD exposure at work referred to secondary healthcare report intermittent hoarseness, loss of voice or difficulty to inhale, referring to functional or organic problems of the larynx. For accurate treatment, proper differential diagnostics is paramount. We present an ongoing observational study in which we describe the prevalence of respiratory, voice and other symptoms related to MD at work in patients referred to secondary healthcare. Case-control setting will be used to evaluate the frequencies of the background factors, bronchial hyperreactivity and laryngeal findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>The study sample consists of patients with workplace MD exposure and associated respiratory tract and\/or voice symptoms referred to Tampere University Hospital. The clinical tests conducted to the study patients included comprehensive lung function tests, laboratory and skin prick tests, imaging and clinical evaluation by specialists of respiratory medicine, oto-rhino-laryngology and phoniatrics. The exposure assessment was performed by an occupational physician. The study patients filled out a questionnaire on previous illnesses and other background factors, which for comparison was also sent to 1500 Finnish-speaking people in the same hospital district randomly selected by the Finnish Population Information System. To explore how common laryngeal disorders and voice symptoms are in general, a part of the tests will be conducted to 50 asymptomatic volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The regional ethics committee of Tampere University Hospital approved the study. All study subjects gave their written informed consent, which is required also from the controls. The results will be communicated locally and internationally as conference papers and journal articles.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2018-026485","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T09:16:22Z","timestamp":1561540582000},"page":"e026485","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Observational cross-sectional study on Symptoms Associated to Moisture DAmage at Workplace: the SAMDAW study protocol"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-8862","authenticated-orcid":false,"given":"Pia","family":"Nyn\u00e4s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarkku","family":"Vilpas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Kankare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Karjalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauri","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jura","family":"Numminen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Tikkakoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leenamaija","family":"Kleemola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Uitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,6,25]]},"reference":[{"key":"2024052011213376000_9.6.e026485.1","unstructured":"WHO. WHO Guidelines for indoor air quality: dampness and mould. Copenhagen: WHO Regional Office for Europe, 2009. http:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0017\/43325\/E92645.pdf."},{"key":"2024052011213376000_9.6.e026485.2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/ina.12136","article-title":"Classroom conditions and CO2 concentrations and teacher health symptom reporting in 10 New York State Schools","volume":"25","author":"Muscatiello","year":"2015","journal-title":"Indoor Air"},{"key":"2024052011213376000_9.6.e026485.3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0668.2003.00190.x"},{"key":"2024052011213376000_9.6.e026485.4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ijheh.2018.01.015","article-title":"Indoor air humidity, air quality, and health - An overview","volume":"221","author":"Wolkoff","year":"2018","journal-title":"Int J Hyg Environ Health"},{"key":"2024052011213376000_9.6.e026485.5","first-page":"10","article-title":"Dust and fibers as a cause of indoor environment problems","volume":"4","author":"Schneider","year":"2008","journal-title":"Scand J Work Environ Heal Suppl"},{"key":"2024052011213376000_9.6.e026485.6","doi-asserted-by":"publisher","DOI":"10.1080\/15459620902735892"},{"key":"2024052011213376000_9.6.e026485.7","doi-asserted-by":"publisher","DOI":"10.1080\/15459620903133667"},{"key":"2024052011213376000_9.6.e026485.8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00420-011-0677-9","article-title":"Prolonged exposure to damp and moldy workplaces and new-onset asthma","volume":"84","author":"Karvala","year":"2011","journal-title":"Int Arch Occup Environ Health"},{"key":"2024052011213376000_9.6.e026485.9","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002410"},{"key":"2024052011213376000_9.6.e026485.10","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq110"},{"key":"2024052011213376000_9.6.e026485.11","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02785-15"},{"key":"2024052011213376000_9.6.e026485.12","first-page":"33","article-title":"Assessment of indoor air problems at work with a questionnaire","volume":"61","author":"Reijula","year":"2004","journal-title":"Occup Environ Med"},{"key":"2024052011213376000_9.6.e026485.13","unstructured":"Ministry of Social Affairs and Health F. Moisture Damages in Workplaces. Memo of the Working Group on Moisture Damages (in Finnish). Helsinki, 2009."},{"key":"2024052011213376000_9.6.e026485.14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijheh.2016.11.012","article-title":"Medical diagnostics for indoor mold exposure","volume":"220","author":"Hurra\u00df","year":"2017","journal-title":"Int J Hyg Environ Health"},{"key":"2024052011213376000_9.6.e026485.15","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqt028"},{"key":"2024052011213376000_9.6.e026485.16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2478\/s13382-011-0011-5","article-title":"Perceived indoor air quality, air-related symptoms and ventilation in Finnish hospitals","volume":"24","author":"Hellgren","year":"2011","journal-title":"Int J Occup Med Environ Health"},{"key":"2024052011213376000_9.6.e026485.17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1239"},{"key":"2024052011213376000_9.6.e026485.18","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2012-101286"},{"key":"2024052011213376000_9.6.e026485.19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12890-016-0306-1","article-title":"Impact of occupational exposures on exacerbation of asthma: a population-based asthma cohort study","volume":"16","author":"Kim","year":"2016","journal-title":"BMC Pulm Med"},{"key":"2024052011213376000_9.6.e026485.20","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.ijheh.2017.09.001","article-title":"Current asthma and asthma-like symptoms among workers at a Veterans Administration Medical Center","volume":"220","author":"Kurth","year":"2017","journal-title":"Int J Hyg Environ Health"},{"key":"2024052011213376000_9.6.e026485.21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/all.12352","article-title":"EAACI Position Paper on assessment of cough in the workplace","volume":"69","author":"Moscato","year":"2014","journal-title":"Allergy"},{"key":"2024052011213376000_9.6.e026485.22","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2014.982288"},{"key":"2024052011213376000_9.6.e026485.23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.clinthera.2013.04.003","article-title":"Chemical sensitivity: pathophysiology or pathopsychology?","volume":"35","author":"Genuis","year":"2013","journal-title":"Clin Ther"},{"key":"2024052011213376000_9.6.e026485.24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/JOM.0000000000001215","article-title":"Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives","volume":"60","author":"Rossi","year":"2018","journal-title":"J Occup Environ Med"},{"key":"2024052011213376000_9.6.e026485.25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/157339711102150702111101","article-title":"Chemical intolerance","volume":"11","author":"Dantoft","year":"2015","journal-title":"Curr Rheumatol Rev"},{"key":"2024052011213376000_9.6.e026485.26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00420-015-1053-y","article-title":"Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity","volume":"89","author":"Andersson","year":"2016","journal-title":"Int Arch Occup Environ Health"},{"key":"2024052011213376000_9.6.e026485.27","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.3390\/ijerph15092047","article-title":"Building-Related Environmental Intolerance and Associated Health in the General Population","volume":"15","author":"Karvala","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"2024052011213376000_9.6.e026485.28","doi-asserted-by":"publisher","DOI":"10.1177\/074823379901500311"},{"key":"2024052011213376000_9.6.e026485.29","first-page":"994","article-title":"[Update on current care guidelines: asthma]","volume":"129","author":"Haahtela","year":"2013","journal-title":"Duodecim"},{"key":"2024052011213376000_9.6.e026485.30","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"2024052011213376000_9.6.e026485.31","doi-asserted-by":"publisher","DOI":"10.1136\/thx.43.11.896"},{"key":"2024052011213376000_9.6.e026485.32","first-page":"279","article-title":"Use of serial measurements of peak flow in the diagnosis of occupational asthma","volume":"8","author":"Burge","year":"1993","journal-title":"Occup Med"},{"key":"2024052011213376000_9.6.e026485.33","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"2024052011213376000_9.6.e026485.34","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00965-2016"},{"key":"2024052011213376000_9.6.e026485.35","unstructured":"Latvala J , Karvala K , Sainio M , et al . Guidelines for Workplace and Occupational Health Actions in Indoor Air Problems (Finnish). Ty\u00f6terveyslaitos 2017 http:\/\/www.julkari.fi\/handle\/10024\/132078 (Accessed 20 Aug 2018)."},{"key":"2024052011213376000_9.6.e026485.36","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.056005377.x"},{"key":"2024052011213376000_9.6.e026485.37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01155.x"},{"key":"2024052011213376000_9.6.e026485.38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/14015430600784386","article-title":"Voice Activity and Participation Profile (VAPP) in assessing the effects of voice disorders on patients' quality of life: validity and reliability of the Finnish version of VAPP","volume":"32","author":"Sukanen","year":"2007","journal-title":"Logoped Phoniatr Vocol"},{"key":"2024052011213376000_9.6.e026485.39","unstructured":"Alaluusua SJM . Psycho-social handicap of voice disorder and its rehabilitation: a pilot study of Finnish version of Voice Handicap Index [In Finnish] [master thesis], 2003."},{"key":"2024052011213376000_9.6.e026485.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(01)00042-X"},{"key":"2024052011213376000_9.6.e026485.41","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-10-1"},{"key":"2024052011213376000_9.6.e026485.42","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"2024052011213376000_9.6.e026485.43","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.18.4.444"},{"key":"2024052011213376000_9.6.e026485.44","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"2024052011213376000_9.6.e026485.45","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2002.005835"},{"key":"2024052011213376000_9.6.e026485.46","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.752"},{"key":"2024052011213376000_9.6.e026485.47","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-026485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T18:31:26Z","timestamp":1716229886000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-026485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,25]]},"published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1136\/bmjopen-2018-026485"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-026485","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}