{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:05:50Z","timestamp":1790996750076,"version":"4.1.0"},"reference-count":30,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,5,20]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To explored 6-month longitudinal changes in conjunctival colonisation and antibiotic resistance profiles of coagulase-negative\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      (CNS) after cataract surgery with 1\u2009month tobramycin treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study between 1 August 2012, and 31 July 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A single medical centre in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 128 Taiwanese patients with 46.9% of male participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Samples from the conjunctival sacs of both operation (OP) and non-OP eyes were obtained separately before cataract surgery and at 1, 3 and 6\u2009months after surgery. Tobramycin (0.3%) treatment was applied four times daily for 1\u2009month postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measure<\/jats:title>\n                    <jats:p>Identification of CNS isolates and their antibiotic susceptibility by using disk diffusion or E-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CNS was detected in 24.2% of patients at baseline. During postoperative follow-up, the CNS colonisation rate did not decrease in either eye but showed an increasing trend in the OP eyes at 1\u2009month (p=0.06). The colonisation rate showed no significant difference between the OP and non-OP eyes from baseline to a specific follow-up. We observed a significant increase (p&lt;0.05) in resistance to tobramycin at 1\u2009month and to ciprofloxacin at 3\u2009months in the OP eyes and to trimethoprim\/sulfamethoxazole at 1\u2009month and 3\u2009months and to oxacillin at 6\u2009months in the non-OP eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During the 6-month postoperative follow-up, 0.3% tobramycin administration failed to reduce CNS colonisation but increased resistance to several antibiotics. Postoperative antibiotic treatment may be replaced by other evidence-endorsed prophylactic routines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-027036","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T06:25:16Z","timestamp":1560925516000},"page":"e027036","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Conjunctival colonisation and antibiotic resistance of coagulase-negative\n                    <i>Staphylococcus<\/i>\n                    after cataract surgery: a 6-month longitudinal study at a medical centre in Taiwan"],"prefix":"10.1136","volume":"9","author":[{"given":"Eugene Yu-Chuan","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan, 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