{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T20:16:54Z","timestamp":1776025014315,"version":"3.50.1"},"reference-count":65,"publisher":"BMJ","issue":"5","funder":[{"name":"Candlelighters Fellowship"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,4,10]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Osteonecrosis is a well-recognised treatment-related morbidity risk in patients diagnosed with acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma (LBL), with a high rate of affected patients requiring surgical intervention. Patients may have asymptomatic changes on imaging studies that spontaneously regress, and little is known about the natural history of osteonecrotic changes seen. The main aim of the British OsteoNEcrosis Study (BONES) is to determine the incidence of symptomatic and asymptomatic osteonecrosis in the lower extremities of survivors of ALL or LBL diagnosed aged 10\u201324 years in the UK at different time points in their treatment. This study also aims to identify risk factors for progression and the development of symptomatic osteonecrosis in this population, as well as specific radiological features that predict for progression or regression in those with asymptomatic osteonecrosis<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>BONES is a prospective, longitudinal cohort study based at principal treatment centres around the UK. Participants are patients aged 10\u201324 years diagnosed with ALL or LBL under standard criteria. Assessment for osteonecrosis will be within 4 weeks of diagnosis, at the end of delayed intensification and 1, 2 and 3 years after the start of maintenance therapy. Assessment will consist of MRI scans of the lower limbs and physiotherapy assessment. Clinical and biochemical data will be collected at each of the time points. Bone mineral density data and vertebral fracture assessment using dual-energy X-ray absorptiometry will be collected at diagnosis and annually for 3 years after diagnosis of malignancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>Ethical approval has been obtained through the Yorkshire and Humber Sheffield Research Ethics Committee (reference number: 16\/YH\/0206). Study results will be published on the study website, in peer-reviewed journals and presented at relevant conferences and via social media.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02598401\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\">NCT02598401<\/jats:ext-link>; Pre-results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-027204","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T18:56:53Z","timestamp":1588877813000},"page":"e027204","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["British OsteoNEcrosis Study (BONES) protocol: a prospective cohort study to examine the natural history of osteonecrosis in older children, teenagers and young adults with acute lymphoblastic leukaemia and lymphoblastic lymphoma"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct02598401","registry":"10.18810\/clinical-trials-gov","type":"preResults"},{"clinical-trial-number":"isrctn64515327","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-1521","authenticated-orcid":false,"given":"Nadia","family":"Amin","sequence":"first","affiliation":[{"name":"Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Kinsey","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK"},{"name":"Department of Paediatric Haematology, Leeds Children\u2019s Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Feltbower","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Leeds, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leeds Teaching Hospital NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Leeds Children\u2019s Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Velangi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology, Birmingham Women\u2019s and Children\u2019s NHS Foundation Trust, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beki","family":"James","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology, Leeds Children\u2019s Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2025101811355604000_9.5.e027204.1","unstructured":"NCIN. 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