{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:56:35Z","timestamp":1782294995909,"version":"3.54.5"},"reference-count":46,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,4,17]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many studies identify factors that contribute to renal prescribing errors, but few examine how healthcare professionals (HCPs) detect and recover from an error or potential patient safety concern. Knowledge of this information could inform advanced error detection systems and decision support tools that help prevent prescribing errors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the cognitive strategies that HCPs used to recognise and manage medication-related problems for patients with renal insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>HCPs submitted documentation about medication-related incidents. We then conducted cognitive task analysis interviews. Qualitative data were analysed inductively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Inpatient and outpatient facilities at a major US Veterans Affairs Medical Centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Physicians, nurses and pharmacists who took action to prevent or resolve a renal-drug problem in patients with renal insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>Emergent themes from interviews, as related to recognition of renal-drug problems and decision-making processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We interviewed 20 HCPs. Results yielded a descriptive model of the decision-making process, comprised of three main stages: detect, gather information and act. These stages often followed a cyclical path due largely to the gradual decline of patients\u2019 renal function. Most HCPs relied on being vigilant to detect patients\u2019 renal-drug problems rather than relying on systems to detect unanticipated cues. At each stage, HCPs relied on different cognitive cues depending on medication type: for renally eliminated medications, HCPs focused on gathering renal dosing guidelines, while for nephrotoxic medications, HCPs investigated the need for particular medication therapy, and if warranted, safer alternatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our model is useful for trainees so they can gain familiarity with managing renal-drug problems. Based on findings, improvements are warranted for three aspects of healthcare systems: (1) supporting the cyclical nature of renal-drug problem management via longitudinal tracking mechanisms, (2) providing tools to alleviate HCPs\u2019 heavy reliance on vigilance and (3) supporting HCPs\u2019 different decision-making needs for renally eliminated versus nephrotoxic medications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-027439","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T06:19:17Z","timestamp":1558765157000},"page":"e027439","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Medication decision-making for patients with renal insufficiency in inpatient and outpatient care at a US Veterans Affairs Medical Centre: a qualitative, cognitive task analysis"],"prefix":"10.1136","volume":"9","author":[{"given":"Nervana","family":"Elkhadragy","sequence":"first","affiliation":[{"name":"Centre for Health Information and Communication, Health Service Research and Development, Department of Veterans Affairs, Roudebush VA Medical Centre, Indianapolis, Indiana, USA"},{"name":"Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda P","family":"Ifeachor","sequence":"additional","affiliation":[{"name":"US Department of Veterans Affairs (VA), Veterans Health Administration, Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie B","family":"Diiulio","sequence":"additional","affiliation":[{"name":"Applied Decision Science, Dayton, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J","family":"Arthur","sequence":"additional","affiliation":[{"name":"US Department of Veterans Affairs (VA), Veterans Health Administration, Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weiner","sequence":"additional","affiliation":[{"name":"Centre for Health Information and Communication, U.S. Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development Service CIN 13-416, Richard L. Roudebush VA Medical Centre; Regenstrief Institute, Inc;, Indiana University, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura G","family":"Militello","sequence":"additional","affiliation":[{"name":"Applied Decision Science, Dayton, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Glassman","sequence":"additional","affiliation":[{"name":"Internal Medicine, Department of Veterans Affairs, Greater Los Angeles Healthcare System, and David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J","family":"Zillich","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa L","family":"Russ","sequence":"additional","affiliation":[{"name":"Centre for Health Information and Communication, Health Service Research and Development, Department of Veterans Affairs, Roudebush VA Medical Centre, Indianapolis, Indiana, USA"},{"name":"Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"2025121600202344000_9.5.e027439.1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s11096-015-0175-3","article-title":"Use of renal risk drugs in patients with renal impairment","volume":"37","author":"Holm","year":"2015","journal-title":"Int J Clin Pharm"},{"key":"2025121600202344000_9.5.e027439.2","doi-asserted-by":"crossref","first-page":"e12960","DOI":"10.1111\/ijcp.12960","article-title":"Inappropriate prescribing in chronic kidney disease: A systematic review of prevalence, associated clinical outcomes and impact of interventions","volume":"71","author":"Tesfaye","year":"2017","journal-title":"Int J Clin Pract"},{"key":"2025121600202344000_9.5.e027439.3","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.172"},{"key":"2025121600202344000_9.5.e027439.4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1053\/j.ajkd.2015.02.343","article-title":"Patient Safety Issues in CKD","volume":"66","author":"Wagner","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"2025121600202344000_9.5.e027439.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2014-003482"},{"key":"2025121600202344000_9.5.e027439.6","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199716030-00005"},{"key":"2025121600202344000_9.5.e027439.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2003.00330.x"},{"key":"2025121600202344000_9.5.e027439.8","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D399"},{"key":"2025121600202344000_9.5.e027439.9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.353"},{"key":"2025121600202344000_9.5.e027439.10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1471-2369-15-200","article-title":"Understanding physicians' behavior toward alerts about nephrotoxic medications in outpatients: a cross-sectional analysis","volume":"15","author":"Cho","year":"2014","journal-title":"BMC Nephrol"},{"key":"2025121600202344000_9.5.e027439.11","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000121"},{"key":"2025121600202344000_9.5.e027439.12","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005020192"},{"key":"2025121600202344000_9.5.e027439.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2011.08.003"},{"key":"2025121600202344000_9.5.e027439.14","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzg046"},{"key":"2025121600202344000_9.5.e027439.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08350-2"},{"key":"2025121600202344000_9.5.e027439.16","first-page":"514","article-title":"Medication dosing errors for patients with renal insufficiency in ambulatory care","volume":"31","author":"Yap","year":"2005","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"2025121600202344000_9.5.e027439.17","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2014-003483"},{"key":"2025121600202344000_9.5.e027439.18","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.72"},{"key":"2025121600202344000_9.5.e027439.19","doi-asserted-by":"crossref","unstructured":"Russ AL , Militello LG , Glassman PA , et al . 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