{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:52:11Z","timestamp":1767167531222,"version":"build-2238731810"},"reference-count":34,"publisher":"BMJ","issue":"8","funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["18281\/A19169"],"award-info":[{"award-number":["18281\/A19169"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["Global Research Awards for Nicotine Dependence"],"award-info":[{"award-number":["Global Research Awards for Nicotine Dependence"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,6,26]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our primary objective was to estimate smoking prevalence and prescribing rates of varenicline and nicotine replacement therapy (NRT) in people with and without general practitioner (GP)-recorded dementia. Our secondary objective was to assess and compare quit rates of smokers with versus without GP-recorded dementia who were prescribed varenicline or NRT for smoking cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cohort study based on the analysis of electronic medical records within the Clinical Practice Research Datalink (2007\u20132015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>683 general practices in England.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>People with and without GP-recorded dementia, aged 18 years and have a code indicating that they are a current smoker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Index prescription of varenicline or NRT (from 1 September 2006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>The primary outcomes were smoking prevalence and prescribing rates of varenicline and NRT (2007\u20132015). The secondary outcome was smoking cessation at 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age and sex-standardised prevalence of smoking was slightly higher in people with GP-recorded dementia than in those without. There were 235\u2009314 people aged 18 years and above prescribed NRT or varenicline. Among smokers with GP-recorded dementia (N=447), 409 were prescribed NRT and 38 varenicline. Smokers with GP-recorded dementia were 74% less likely (95% CI 64% to 82%) to be prescribed varenicline than NRT, compared with smokers without GP-recorded dementia. Compared with people without GP-recorded dementia, people with GP-recorded dementia had consistently lower prescribing rates of varenicline from 2007 to 2015. Two years after prescription, there was no clear evidence for a difference in the likelihood of smoking cessation after prescription of these medications between individuals with and without dementia (OR 1.0, 95%\u2009CI 0.8 to 1.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Between 2007 and 2015, people with GP-recorded dementia were less likely to be prescribed varenicline than those without dementia. Quit rates following prescription of either NRT or varenicline were similar in those with and without dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-027569","type":"journal-article","created":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T07:45:41Z","timestamp":1567237541000},"page":"e027569","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Use of varenicline and nicotine replacement therapy in people with and without general practitioner-recorded dementia: retrospective cohort study of routine electronic medical records"],"prefix":"10.1136","volume":"9","author":[{"given":"Taha","family":"Itani","sequence":"first","affiliation":[{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK"},{"name":"UK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Martin","sequence":"additional","affiliation":[{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK"},{"name":"NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK"},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheeraj","family":"Rai","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK"},{"name":"Centre for Academic Mental Health, School of Social and Community Medicine, University of Bristol, Bristol, UK"},{"name":"Avon & Wiltshire Partnership NHS Mental Health Trust, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-8668","authenticated-orcid":false,"given":"Tim","family":"Jones","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West (NIHR CLAHRC West) at University Hospitals Bristol NHS Foundation Trust, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2185-0162","authenticated-orcid":false,"given":"Gemma","family":"Taylor","sequence":"additional","affiliation":[{"name":"Addiction and Mental Health Group (AIM) Department of Psychology, University of Bath, Bath, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyla","family":"Thomas","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Munafo","sequence":"additional","affiliation":[{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK"},{"name":"UK Centre for Tobacco and Alcohol Studies, School of Psychological Science, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Davies","sequence":"additional","affiliation":[{"name":"Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK"},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Taylor","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK"},{"name":"Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"2025121406523427000_9.8.e027569.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30819-X"},{"key":"2025121406523427000_9.8.e027569.2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00016.x"},{"key":"2025121406523427000_9.8.e027569.3","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm116"},{"key":"2025121406523427000_9.8.e027569.4","unstructured":"McKenzie J , Bhatti L , Tursan d\u2019Espaignet E . 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