{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:32:42Z","timestamp":1779939162137,"version":"3.53.1"},"reference-count":62,"publisher":"BMJ","issue":"8","funder":[{"name":"National New Investigator of the Heart and Stroke Foundation Canada"},{"name":"Heart and Stroke Foundation\/University of Alberta Professorship of Neonatal Resuscitation"},{"name":"Alberta New Investigator of the Heart and Stroke Foundation Alberta"},{"name":"Women and Children\u2019s Health Research Institute"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,7,15]]},"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>As gestational age decreases, incidence of bronchopulmonary dysplasia (BPD) and chronic lung disease increases. There are many interventions used in the delivery room to prevent acute lung injury and consequently BPD in these patients. The availability of different treatment options often poses a practical challenge to the practicing neonatologist when it comes to making an evidence-based choice as the multitude of pairwise systematic reviews including Cochrane reviews that are currently available only provide a narrow perspective through head-to-head comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will conduct a systematic review of all randomised controlled trials evaluating delivery room interventions within the first golden hour after birth for prevention of BPD. The primary outcome includes BPD. Secondary outcomes include death at 36 weeks of postmenstrual age or before discharge; severe intraventricular haemorrhage (grade 3 or 4 based on the Papile criteria); any air leak syndromes (including pneumothorax or pulmonary interstitial emphysema); retinopathy of prematurity (any stage) and neurodevelopmental impairment at 18\u201324 months. We will search from their inception to August 2018, the following databases: Medline, EMBASE and Cochrane Central Register of Controlled Trials as well as grey literature resources. Two reviewers will independently screen titles and abstracts, review full texts, extract information and assess the risk of bias and the confidence in the estimate (with Grading of Recommendations Assessment, Development and Evaluation approach). This review will use Bayesian network meta-analysis approach which allows the comparison of the multiple delivery room interventions for prevention of BPD. We will perform a Bayesian network meta-analysis to combine the pooled direct and indirect treatment effect estimates for each outcome, effectiveness and safety of delivery room interventions for prevention of BPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The proposed protocol is a network meta-analysis, which has been registered on PROSPERO International prospective register of systematic reviews (CRD42018078648). The results will provide an evidence-based guide to choosing the right sequence of early postnatal interventions that will be associated with the least likelihood of inducing lung injury and BPD in preterm infants. Furthermore, we will identify knowledge gaps and will encourage further research for other therapeutic options. Therefore, its results will be disseminated through peer-reviewed publications and conference presentations. Due to the nature of the design, no ethics approval is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-028066","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T06:07:44Z","timestamp":1566194864000},"page":"e028066","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Delivery room interventions to prevent bronchopulmonary dysplasia in preterm infants: a protocol for a systematic review and network meta-analysis"],"prefix":"10.1136","volume":"9","author":[{"given":"Souvik","family":"Mitra","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Dalhousie University, IWK Health Center, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Disher","sequence":"additional","affiliation":[{"name":"School of Nursing, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[{"name":"Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy, IWK Health Centre, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Mccord","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dalhousie University, IWK Health Center, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Chayapathi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dalhousie University, IWK Health Center, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlee","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dalhousie University, IWK Health Center, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[{"name":"Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada"},{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,8,18]]},"reference":[{"key":"2025121600592969000_9.8.e028066.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80442-4"},{"key":"2025121600592969000_9.8.e028066.2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.82.4.527","article-title":"Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period","volume":"82","author":"Shennan","year":"1988","journal-title":"Pediatrics"},{"key":"2025121600592969000_9.8.e028066.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10244"},{"key":"2025121600592969000_9.8.e028066.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2522"},{"key":"2025121600592969000_9.8.e028066.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1806OC"},{"key":"2025121600592969000_9.8.e028066.6","doi-asserted-by":"crossref","DOI":"10.1542\/peds.112.5.e359","article-title":"Cognitive and academic consequences of bronchopulmonary dysplasia and very low birth weight: 8-year-old outcomes","volume":"112","author":"Short","year":"2003","journal-title":"Pediatrics"},{"key":"2025121600592969000_9.8.e028066.7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/jamapediatrics.2017.5323","article-title":"Cognitive outcomes of children born extremely or very preterm since the 1990s and associated risk factors: a meta-analysis and meta-regression","volume":"172","author":"Twilhaar","year":"2018","journal-title":"JAMA Pediatr"},{"key":"2025121600592969000_9.8.e028066.8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-051OC"},{"key":"2025121600592969000_9.8.e028066.9","doi-asserted-by":"crossref","DOI":"10.1186\/1465-9921-10-19","article-title":"Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs","volume":"10","author":"Wallace","year":"2009","journal-title":"Respir Res"},{"key":"2025121600592969000_9.8.e028066.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00444298"},{"key":"2025121600592969000_9.8.e028066.11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1152\/jappl.1987.62.1.164","article-title":"Distortion of chest wall and work of diaphragm in preterm infants","volume":"62","author":"Heldt","year":"1987","journal-title":"J Appl Physiol"},{"key":"2025121600592969000_9.8.e028066.12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1152\/jappl.1987.62.1.170","article-title":"Dynamics of chest wall in preterm infants","volume":"62","author":"Heldt","year":"1987","journal-title":"J Appl Physiol"},{"key":"2025121600592969000_9.8.e028066.13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/jp.2017.74","article-title":"Delivery room interventions to prevent bronchopulmonary dysplasia in extremely preterm infants","volume":"37","author":"Foglia","year":"2017","journal-title":"J Perinatol"},{"key":"2025121600592969000_9.8.e028066.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.01.011"},{"key":"2025121600592969000_9.8.e028066.15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2017.10.231","article-title":"Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis","volume":"218","author":"Fogarty","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2025121600592969000_9.8.e028066.16","doi-asserted-by":"crossref","unstructured":"Schm\u00f6lzer GM , Kumar M , Pichler G , et al . Non-Invasive versus invasive respiratory support in preterm infants at birth: systematic review and meta-analysis. BMJ 2013;347.doi:10.1136\/bmj.f5980","DOI":"10.1136\/bmj.f5980"},{"key":"2025121600592969000_9.8.e028066.17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jpeds.2015.11.053","article-title":"Cerebral oxygen saturation to guide oxygen delivery in preterm neonates for the immediate transition after birth: a 2-Center randomized controlled pilot feasibility trial","volume":"170","author":"Pichler","year":"2016","journal-title":"J Pediatr"},{"key":"2025121600592969000_9.8.e028066.18","unstructured":"Collaboration TC . The Cochrane Handbook for systematic reviews of interventions version 5.1.0. Higgins JPT, and green, S, editor 2011."},{"key":"2025121600592969000_9.8.e028066.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00347.x"},{"key":"2025121600592969000_9.8.e028066.20","unstructured":"Jonas DE , Wilkins TM , Bangdiwala S , et al . Findings of Bayesian Mixed Treatment Comparison Meta-Analyses: Comparison and Exploration Using Real-World Trial Data and Simulation [Internet. Rockville (MD: Agency for Healthcare Research and Quality (US), 2013."},{"key":"2025121600592969000_9.8.e028066.21","doi-asserted-by":"publisher","DOI":"10.1159\/000178770"},{"key":"2025121600592969000_9.8.e028066.22","doi-asserted-by":"crossref","unstructured":"Peleg B , Globus O , Granot M , et al . \u201cGolden Hour\u201d quality improvement intervention and short-term outcome among preterm infants. J Perinatol 2018;31.","DOI":"10.1038\/s41372-018-0254-0"},{"key":"2025121600592969000_9.8.e028066.23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/pch\/pxx175","article-title":"Golden hour management practices for infants","volume":"23","author":"Shah","year":"2018","journal-title":"Paediatr Child Health"},{"key":"2025121600592969000_9.8.e028066.24","doi-asserted-by":"crossref","unstructured":"Shamseer L , Moher D , Clarke M , et al . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015;349.doi:10.1136\/bmj.g7647","DOI":"10.1136\/bmj.g7647"},{"key":"2025121600592969000_9.8.e028066.25","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"2025121600592969000_9.8.e028066.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"2025121600592969000_9.8.e028066.27","unstructured":"World-class systematic review management . Covidence systematic review software, veritas health innovation. Melbourne, Australia, 2019."},{"key":"2025121600592969000_9.8.e028066.28","unstructured":"PRISMA . Preferred Reporting Items for Systematic Reviews and Meta-Analyses [online], 2018. Available: http:\/\/www.prisma-statement.org\/statement.htm [Accessed 20 Apr 2018]."},{"key":"2025121600592969000_9.8.e028066.29","doi-asserted-by":"crossref","unstructured":"Introduction to Evidence Synthesis . Network Meta\u2010Analysis for Decision Making [Internet. John Wiley & Sons, Ltd, 2018: 1\u201317.","DOI":"10.1002\/9781118951651.ch1"},{"key":"2025121600592969000_9.8.e028066.30","doi-asserted-by":"crossref","unstructured":"Riley RD , Higgins JPT , Deeks JJ . Interpretation of random effects meta-analyses. BMJ 2011;342.doi:10.1136\/bmj.d549","DOI":"10.1136\/bmj.d549"},{"key":"2025121600592969000_9.8.e028066.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-985X.2008.00552.x"},{"key":"2025121600592969000_9.8.e028066.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"2025121600592969000_9.8.e028066.33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PLoS One"},{"key":"2025121600592969000_9.8.e028066.34","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1002\/sim.6321","article-title":"A selection model for accounting for publication bias in a full network meta-analysis","volume":"33","author":"Mavridis","year":"2014","journal-title":"Stat Med"},{"key":"2025121600592969000_9.8.e028066.35","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2112"},{"key":"2025121600592969000_9.8.e028066.36","doi-asserted-by":"crossref","first-page":"267-270","DOI":"10.7326\/M13-2886","article-title":"Random-effects meta-analysis of inconsistent effects: a time for change","volume":"160","author":"Cornell","year":"2014","journal-title":"Ann Intern Med"},{"key":"2025121600592969000_9.8.e028066.37","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"2025121600592969000_9.8.e028066.38","doi-asserted-by":"crossref","unstructured":"Dias S , Sutton AJ , Ades AE , et al . Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials. Med Decis Mak 2013;33.","DOI":"10.1177\/0272989X12458724"},{"key":"2025121600592969000_9.8.e028066.39","unstructured":"Gelman A , Carlin J , Stern H , et al . Chapter 2: Single Parameter models. In: Bayesian data analysis. 3th edn. New York: CRC Press, 2015."},{"key":"2025121600592969000_9.8.e028066.40","unstructured":"Gabry J , Simpson D , Vehtari A , et al . Visualization in Bayesian workflow, 2017. Available: http:\/\/arxiv.org\/abs\/1709.01449"},{"key":"2025121600592969000_9.8.e028066.41","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp014"},{"key":"2025121600592969000_9.8.e028066.42","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/0272989X13487604","article-title":"Evidence synthesis for decision making 3: subgroups, meta-regression, bias, and Bias-Adjustment","volume":"33","author":"Dias","year":"2013","journal-title":"Med Decis Mak [Internet]"},{"key":"2025121600592969000_9.8.e028066.43","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys041"},{"key":"2025121600592969000_9.8.e028066.44","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177011136"},{"key":"2025121600592969000_9.8.e028066.45","unstructured":"Plummer M . JAGS: just another Gibbs sampler, 2016. Available: http:\/\/mcmc-jags.sourceforge.net\/ [Accessed 14 Mar 2017]."},{"key":"2025121600592969000_9.8.e028066.46","unstructured":"R Core Team . R: a language and environment for statistical computing, 2018. Available: https:\/\/cran.r-project.org\/"},{"key":"2025121600592969000_9.8.e028066.47","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12455847"},{"key":"2025121600592969000_9.8.e028066.48","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6188"},{"key":"2025121600592969000_9.8.e028066.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.08.012"},{"key":"2025121600592969000_9.8.e028066.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"2025121600592969000_9.8.e028066.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"2025121600592969000_9.8.e028066.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.017"},{"key":"2025121600592969000_9.8.e028066.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.012"},{"key":"2025121600592969000_9.8.e028066.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.03.017"},{"key":"2025121600592969000_9.8.e028066.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.011"},{"key":"2025121600592969000_9.8.e028066.56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011054","article-title":"Indirect comparisons: a review of reporting and methodological quality","volume":"5","author":"Donegan","year":"2010","journal-title":"PLoS One"},{"key":"2025121600592969000_9.8.e028066.57","doi-asserted-by":"crossref","unstructured":"Baker SG , Kramer BS . The transitive fallacy for randomized trials: if a bests B and B bests C in separate trials, is a better than C? BMC Med Res Methodol 2002;2.doi:10.1186\/1471-2288-2-13","DOI":"10.1186\/1471-2288-2-13"},{"key":"2025121600592969000_9.8.e028066.58","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-2-201307160-00008"},{"key":"2025121600592969000_9.8.e028066.59","doi-asserted-by":"crossref","unstructured":"Puhan MA , Sch\u00fcnemann HJ , Murad MH , et al . A grade Working group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ 2014;349.doi:10.1136\/bmj.g5630","DOI":"10.1136\/bmj.g5630"},{"key":"2025121600592969000_9.8.e028066.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.09.005"},{"key":"2025121600592969000_9.8.e028066.61","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/0272989X13485155","article-title":"Evidence synthesis for decision making 5: the baseline natural history model","volume":"33","author":"Dias","year":"2013","journal-title":"Med Decis Mak"},{"key":"2025121600592969000_9.8.e028066.62","unstructured":"Tervonen T . New directions in stochastic Multicriteria acceptability analysis, 2007. Available: http:\/\/www.utupub.fi\/handle\/10024\/28151 [Accessed 11 Nov 2018]."}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-028066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T08:59:48Z","timestamp":1765875588000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-028066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":62,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,18]]},"published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1136\/bmjopen-2018-028066"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-028066","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}