{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:27:30Z","timestamp":1765740450860,"version":"3.48.0"},"reference-count":25,"publisher":"BMJ","issue":"11","funder":[{"name":"Guanghua Excellent PI Team","award":["2016-06"],"award-info":[{"award-number":["2016-06"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015075"],"award-info":[{"award-number":["JDZX2015075"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015076"],"award-info":[{"award-number":["JDZX2015076"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015077"],"award-info":[{"award-number":["JDZX2015077"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015078"],"award-info":[{"award-number":["JDZX2015078"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015079"],"award-info":[{"award-number":["JDZX2015079"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015080"],"award-info":[{"award-number":["JDZX2015080"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015081"],"award-info":[{"award-number":["JDZX2015081"]}]},{"name":"National Clinical research base of TCM project","award":["JDZX2015082"],"award-info":[{"award-number":["JDZX2015082"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1704300"],"award-info":[{"award-number":["2018YFC1704300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai TCM Medical Center of Chronic Disease","award":["2017ZZ01010"],"award-info":[{"award-number":["2017ZZ01010"]}]},{"name":"Three Years Action to Accelerate the Development of Traditional Chinese Medicine Plan","award":["ZY(2018-2020)-CCCX-3003"],"award-info":[{"award-number":["ZY(2018-2020)-CCCX-3003"]}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81574001"],"award-info":[{"award-number":["81574001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81673991"],"award-info":[{"award-number":["81673991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81730107"],"award-info":[{"award-number":["81730107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Innovative Research Team, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2015RA4002"],"award-info":[{"award-number":["2015RA4002"]}]},{"name":"Program for Innovative Research Team of Ministry of Education of China","award":["IRT1270"],"award-info":[{"award-number":["IRT1270"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,10,22]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45\u201380 years old and male residents aged 50\u201380 years old are identified through permanent resident lists. All the enrolled participants will complete questionnaires on their personal characteristics and histories. The bone mineral density of their lumbar vertebrae and left hip will be measured and serum bone metabolism parameters assessed. Polymorphisms of genes related to vitamin D metabolism and transportation will be detected, and their relationship with the risk of osteoporosis, and osteoporotic fracture, will be analysed. About 18\u2009000 residents will be involved in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study was approved by Institutional Ethics Board of Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine (2016LCSY065). Results will be published in peer-reviewed journals. The results of this study are expected to improve the understanding of the association between polymorphisms of genes related to vitamin D metabolism and transportation and the risk of osteoporosis and osteoporotic fracture among middle-aged and older residents of China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\" xlink:href=\"NCT02958020\">NCT02958020<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-028084","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T04:35:14Z","timestamp":1574656514000},"page":"e028084","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct02958020","registry":"10.18810\/clinical-trials-gov","type":"preResults"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4611-2003","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"},{"name":"Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shu","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"},{"name":"Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Wen","family":"Xie","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De","family":"Liang","sequence":"additional","affiliation":[{"name":"The First Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Lai","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Chao","family":"Lin","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Wei","sequence":"additional","affiliation":[{"name":"Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[{"name":"The 309th Hospital of Chinese People's Liberation Army, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yang","family":"Leng","sequence":"additional","affiliation":[{"name":"Hospital Affiliated to Changchun University of Traditional Chinese Medicine, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Luoyang Zhenggu Hospital of Henan Province, Luoyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Zhan","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ren","family":"Tao","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"},{"name":"Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Jun","family":"Cui","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"},{"name":"Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Shi","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China"},{"name":"Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,11,24]]},"reference":[{"key":"2025121411234232000_9.11.e028084.1","doi-asserted-by":"crossref","first-page":"e807","DOI":"10.1016\/S2214-109X(17)30222-X","article-title":"National incidence of traumatic fractures in China: a retrospective survey of 512\u2008187 individuals","volume":"5","author":"Chen","year":"2017","journal-title":"The Lancet Global Health"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.2","DOI":"10.1002\/jcp.22244"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.3","DOI":"10.1111\/j.1365-2265.2010.03847.x"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.4","DOI":"10.1056\/NEJMra070553"},{"key":"2025121411234232000_9.11.e028084.5","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g2035","article-title":"Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials","volume":"348","author":"Theodoratou","year":"2014","journal-title":"BMJ"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.6","DOI":"10.1210\/jc.2013-4320"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.7","DOI":"10.1172\/JCI5244"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.8","DOI":"10.1038\/nrc3691"},{"key":"2025121411234232000_9.11.e028084.9","first-page":"350","article-title":"Vdr and TNFSF11 polymorphisms are associated with osteoporosis in Thai patients","volume":"9","author":"Techapatiphandee","year":"2018","journal-title":"Biomed Rep"},{"key":"2025121411234232000_9.11.e028084.10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12291-017-0706-x","article-title":"Association of vitamin D receptor (FokI and BsmI) gene polymorphism with bone mineral density and their effect on 25-hydroxyvitamin D level in North Indian postmenopausal women with osteoporosis","volume":"33","author":"Ahmad","year":"2018","journal-title":"Ind J Clin Biochem"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.11","DOI":"10.1056\/NEJMoa1306357"},{"key":"2025121411234232000_9.11.e028084.12","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.12659\/MSM.894793","article-title":"Vitamin D deficiency in Uygurs and Kazaks is associated with polymorphisms in CYP2R1 and DHCR7\/NADSYN1 genes","volume":"21","author":"Xu","year":"2015","journal-title":"Med Sci Monit"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.13","DOI":"10.1007\/s00223-001-2079-6"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.14","DOI":"10.1007\/s00774-009-0080-8"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.15","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"unstructured":"International Osteoporosis Foundation . IOF One-minute osteoporosis risk test [EB\/OL]. Available: https:\/\/www.Iofbonehealth.Org\/iof-one-minute-osteoporosis-risk-test","key":"2025121411234232000_9.11.e028084.16"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.17","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"2025121411234232000_9.11.e028084.18","first-page":"265","article-title":"Study on the reliability and validity of international physical activity questionnaire (Chinese vision, IPAQ)","volume":"25","author":"NN","year":"2004","journal-title":"Zhong hua Liu Xing Bing Xue Za Zhi"},{"key":"2025121411234232000_9.11.e028084.19","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1007\/s00198-011-1840-6","article-title":"Regional and age-related variations in the proportions of hip fractures and major fractures among postmenopausal women: the global longitudinal study of osteoporosis in women","volume":"23","author":"Pfeilschifter","year":"2012","journal-title":"Osteoporos Int"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.20","DOI":"10.1093\/ageing\/aft167"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.21","DOI":"10.1002\/jbmr.2072"},{"doi-asserted-by":"publisher","key":"2025121411234232000_9.11.e028084.22","DOI":"10.1007\/s11657-012-0095-y"},{"key":"2025121411234232000_9.11.e028084.23","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/jbmr.2146","article-title":"Major osteoporotic to hip fracture ratios in Canadian men and women with Swedish comparisons: a population-based analysis","volume":"29","author":"Lam","year":"2014","journal-title":"J Bone Miner Res"},{"key":"2025121411234232000_9.11.e028084.24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1127\/anthranz\/58\/2000\/193","article-title":"Genetic polymorphism of group-specific component\/vitamin-D-binding protein subtypes in six populations from north-eastern China","volume":"58","author":"Yin","year":"2000","journal-title":"Anthranz"},{"key":"2025121411234232000_9.11.e028084.25","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2217\/pgs-2018-0063","article-title":"Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur","volume":"19","author":"Kang","year":"2018","journal-title":"Pharmacogenomics"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2018-028084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T19:23:49Z","timestamp":1765740229000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2018-028084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,24]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/bmjopen-2018-028084"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2018-028084","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}