{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:30:07Z","timestamp":1765816207481,"version":"3.48.0"},"reference-count":36,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Municipal Commission of Health and Family Planning"},{"name":"Longyi Innovation Team Program"},{"name":"Program for Innovative Research Team of Ministry of Education of China"},{"name":"Program for Innovative Research Team of Ministry of Science and Technology of China"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,6,10]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine the relationship between serum vitamin B\n                      <jats:sub>6<\/jats:sub>\n                      (Vit B\n                      <jats:sub>6<\/jats:sub>\n                      ) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The present study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and participants<\/jats:title>\n                    <jats:p>A total of 1829 residents (men \u226550 years and women \u226545 years) from two subdistricts were recruited from July 2015 to February 2016 in Shanghai, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measures<\/jats:title>\n                    <jats:p>\n                      Recruited residents were grouped (control, osteopenia and osteoporosis) according to their lumbar spine bone mineral density, measured through dual-energy X-ray absorptiometry. Serum Vit B\n                      <jats:sub>6<\/jats:sub>\n                      concentrations, bone turnover marker concentrations and calcium and phosphorus metabolism parameters were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant linear trend between serum Vit B\n                      <jats:sub>6<\/jats:sub>\n                      concentrations and lumbar bone mass was observed in the men. In the women, the average osteoporosis risk was 61% higher at serum Vit B\n                      <jats:sub>6<\/jats:sub>\n                      concentrations of &lt;19.2 \u03bcg\/L than at those of &gt;26.9 \u03bcg\/L (OR 1.61, 95% CI 1.00 to 2.58). However, there was no significance after controlling of serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration, respectively. In the osteoporotic women, the serum Vit B\n                      <jats:sub>6<\/jats:sub>\n                      concentration was significantly negatively correlated to concentrations of bone turnover marker including N-terminal propeptide of type I collagen, \u03b2-C-terminal telopeptide of type I collagen and osteocalcin. It was also positively related to the serum 25-hydroxy-vitamin D concentration and inversely related to the serum parathyroid hormone concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      A relatively low serum Vit B\n                      <jats:sub>6<\/jats:sub>\n                      concentration, even in the normal range, may be a risk factor for osteoporosis in postmenopausal women, which is dependent on serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"NCT02958020\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial post-results\">NCT02958020<\/jats:ext-link>\n                      ; Post-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-028129","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:15:22Z","timestamp":1562310922000},"page":"e028129","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Association between serum vitamin B\n                    <sub>6<\/sub>\n                    concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional 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