{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:12:47Z","timestamp":1777435967231,"version":"3.51.4"},"reference-count":38,"publisher":"BMJ","issue":"9","funder":[{"name":"D\u00e9partement de chirurgie de l\u2019Universit\u00e9 de Sherbrooke"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,8,16]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obstructive sleep apnoea affects up to 6% of children worldwide. Although current guidelines recommend systematic tonsillectomy and adenoidectomy, many children do not benefit from these interventions. Drug-induced sleep endoscopy (DISE) allows the dynamic evaluation of patients\u2019 airways to identify the specific anatomic sites of obstruction. This intervention can potentially guide subsequent invasive procedures to optimise outcomes and minimise the number of children exposed to unnecessary operations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will identify randomised controlled trials and controlled observational studies comparing DISE-directed interventions to systematic tonsillectomy and adenoidectomy in paediatric populations. We will search MEDLINE, EMBASE, CINAHL, CENTRAL as well as clinical trial registries and conference proceedings (initial electronic search date 9 October 2018). Screening, data extraction and risk of bias assessments will be performed in duplicate by independent reviewers. We will use the Grading of Recommendations Assessment, Development and Evaluation approach to assess the overall quality of evidence and present our results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval is not required for this systematic review of published data. This review will be presented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will present our findings at otorhinolaryngology conferences and publish a report in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42018085370.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-028242","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T08:55:17Z","timestamp":1568192117000},"page":"e028242","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Drug-induced sleep endoscopy compared with systematic adenotonsillectomy in the management of obstructive sleep apnoea in children: a systematic review and meta-analysis protocol"],"prefix":"10.1136","volume":"9","author":[{"given":"Anne-Sophie","family":"Pr\u00e9vost","sequence":"first","affiliation":[{"name":"Division of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Surgery, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Hylands","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"Gervais","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Surgery, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Praud","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology\u2014Department of Pediatrics, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Battista","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"D\u00e9ziel-Malouin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Lachance","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Lamontagne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"2025120520482803000_9.9.e028242.1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.8.775"},{"key":"2025120520482803000_9.9.e028242.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1672"},{"key":"2025120520482803000_9.9.e028242.3","doi-asserted-by":"publisher","DOI":"10.1017\/S135561770410708X"},{"key":"2025120520482803000_9.9.e028242.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.12.011"},{"key":"2025120520482803000_9.9.e028242.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2105118"},{"key":"2025120520482803000_9.9.e028242.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.11.012"},{"key":"2025120520482803000_9.9.e028242.7","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMoa1215881","article-title":"A randomized trial of adenotonsillectomy for childhood sleep apnea","volume":"368","author":"Marcus","year":"2013","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025120520482803000_9.9.e028242.8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.872"},{"key":"2025120520482803000_9.9.e028242.9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24662"},{"key":"2025120520482803000_9.9.e028242.10","unstructured":"Berry RB . 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