{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:34:08Z","timestamp":1769679248219,"version":"3.49.0"},"reference-count":28,"publisher":"BMJ","issue":"9","funder":[{"name":"Foundation for Science and Technology Development of Ton Duc Thang University","award":["FOSTECT.2014.BR.09"],"award-info":[{"award-number":["FOSTECT.2014.BR.09"]}]},{"name":"a grant from the Department of Science and Technology of Ho Chi Minh City"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,8,22]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The association between osteoporosis and atherosclerosis remains controversial. We sought to define the relationship between carotid intima-media thickness and bone mineral density (BMD) in individuals of Vietnamese background.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Cross-sectional study in Ho Chi Minh City, Vietnam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study involved 1460 individuals (559 men) aged 50 years and older (average age 59\u2009years) who were randomly recruited from the community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>BMD at the femoral neck and lumbar spine was measured by dual-energy X-ray absorptiometry (Hologic, Waltham, Massachusetts, USA). Carotid intima-media thickness (cIMT) was measured using a Philips Ultrasonography (HD7XE). The presence of atherosclerotic plaque was ascertained for each individual. The association between cIMT and BMD was analysed by a multiple linear regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In unadjusted analysis, cIMT was positively associated with femoral neck BMD in men (p=0.005), but not in women (p=0.242). After adjusting for age, smoking, diabetes and hypertension, the association remained statistically significant in men (partial R\n                      <jats:sup>2<\/jats:sup>\n                      =0.005; p=0.015) but not in women (partial R\n                      <jats:sup>2<\/jats:sup>\n                      =0.008; p=0.369). When the analysis was limited to individuals aged 60 years and older, the association between cIMT and BMD was no longer statistically significant. There was no statistically significant association between cIMT and lumbar spine BMD in either men or women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Vietnamese individuals aged 50 years and older, there is a clinically non-significant but statistically significant association between carotid intima-media thickness and BMD in men, not in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2018-028603","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T13:05:18Z","timestamp":1568725518000},"page":"e028603","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association between carotid intima-media thickness and bone mineral density: a cross-sectional study in Vietnamese men and women aged 50 years and older"],"prefix":"10.1136","volume":"9","author":[{"given":"Lich T","family":"Nguyen","sequence":"first","affiliation":[{"name":"Bone and Muscle Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam"},{"name":"Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinh N","family":"Pham","sequence":"additional","affiliation":[{"name":"Tam Duc Heart Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuong M N","family":"Chau","sequence":"additional","affiliation":[{"name":"Bone and Muscle Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan T","family":"Ho-Pham","sequence":"additional","affiliation":[{"name":"Bone and Muscle Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam"},{"name":"Department of Internal Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan V","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Bone Biology Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia"},{"name":"School of Biomedical Engineering, University of Technology, Sydney, New South Wales, 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