{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:22:19Z","timestamp":1765606939312,"version":"3.48.0"},"reference-count":15,"publisher":"BMJ","issue":"6","funder":[{"name":"Medtronic Foundation Medical Research Council of South Africa, national research Foundation of south africa"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,5,21]]},"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Rheumatic heart disease (RHD) is a preventable chronic condition affecting the valves of the heart. RHD prevention and care programmes have historically originated in more developed countries, implemented in a targeted (or vertical) manner and evaluated using non-controlled approaches. Taking a broad view of the integration of RHD activities within the whole system is critical for health planning in low-income regions with a high burden of RHD and less robust health systems. Therefore, we propose to conduct a systematic review to assess RHD programme models in order to gain a better understanding of the extent of integration within relevant health systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A predefined search strategy will be used to search for relevant articles published in English from January 1990 to December 2017. Electronic databases PubMed, Scopus, Web of Science, Africa Wide, CINAHL, Cochrane Central Register of Controlled Trials, Google Scholar and Global Index Medicus will be searched, as well as reference lists of relevant articles published. A standardised data extraction form will be used to obtain information for analysis from the included studies. The quality, reliability and risk of bias of included studies will be assessed using design-specific criteria. Programme integration will be analysed according to stewardship and governance, financing, planning, service delivery, monitoring and evaluation, and demand generation. Programme inputs, outputs and impact will also be described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>No ethical approval is required. Findings will be disseminated in a peer-review journal in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42017076307<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-028908","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T13:35:17Z","timestamp":1561210517000},"page":"e028908","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating the prevention and control of rheumatic heart disease into country health systems: a systematic review protocol"],"prefix":"10.1136","volume":"9","author":[{"given":"Jessica","family":"Abrams","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Red Cross War Memorial Children\u2019s Hospital, Cape Town, Western Cape, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Watkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, Seattle, WA, United States"},{"name":"Department of Medicine, University of Cape Town, Western Cape, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila H","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Red Cross War Memorial Children\u2019s Hospital, Cape Town, Western Cape, South Africa"},{"name":"Research, Evaluation, Analysis, Learning and Monitoring (REALM), Save the Children International, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cape Town, Western Cape, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-2760","authenticated-orcid":false,"given":"Liesl J","family":"Zuhlke","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Red Cross War Memorial Children\u2019s Hospital, Cape Town, Western Cape, South Africa"},{"name":"Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"key":"2025121222175998000_9.6.e028908.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603693"},{"key":"2025121222175998000_9.6.e028908.2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181fbd85b"},{"key":"2025121222175998000_9.6.e028908.3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3329\/jhpn.v31i1.14751","article-title":"Risk factors of rheumatic heart disease in Bangladesh: a case-control study","volume":"31","author":"Riaz","year":"2013","journal-title":"J Health Popul Nutr"},{"key":"2025121222175998000_9.6.e028908.4","unstructured":"Patterson MJ . Streptococcus: In. Baron S , ed. Medical Microbiology, 1996. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21413248. (Accessed 22 Jan 2018)."},{"key":"2025121222175998000_9.6.e028908.5","unstructured":"Sika-Paotonu D , Beaton A , Raghu A , et al . In: Ferretti J , Stevens D , Fischetti V , eds. Streptococcus pyogenes: Basic Biology to Clinical Manifestations. Oklahoma City (OK: University of Oklahoma Health Sciences Center, 2016:1\u201357. Updated 3 Apr 2017."},{"key":"2025121222175998000_9.6.e028908.6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.gheart.2016.12.001","article-title":"The WHF Roadmap for Reducing CV Morbidity and Mortality Through Prevention and Control of RHD","volume":"12","author":"Palafox","year":"2017","journal-title":"Glob Heart"},{"key":"2025121222175998000_9.6.e028908.7","first-page":"285","article-title":"The community control of rheumatic fever and rheumatic heart disease: report of a WHO international cooperative project","volume":"59","author":"Strasser","year":"1981","journal-title":"Bull World Health Organ"},{"key":"2025121222175998000_9.6.e028908.8","first-page":"135","article-title":"Prevention and control of rheumatic fever and rheumatic heart disease: the Cuban experience (1986-1996-2002)","volume":"19","author":"Nordet","year":"2008","journal-title":"Cardiovasc J Afr"},{"key":"2025121222175998000_9.6.e028908.9","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2015.0514"},{"key":"2025121222175998000_9.6.e028908.10","unstructured":"RHD Action. 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Washington DC: The World Bank, 2011.","DOI":"10.1596\/978-0-8213-8541-8"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2019-028908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:18:08Z","timestamp":1765606688000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2019-028908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,22]]},"published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1136\/bmjopen-2019-028908"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2019-028908","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}