{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:36:07Z","timestamp":1760834167945,"version":"build-2065373602"},"reference-count":35,"publisher":"BMJ","issue":"9","funder":[{"name":"German Spine Society","award":["Grant 12\/2017"],"award-info":[{"award-number":["Grant 12\/2017"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,8,1]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The diagnosis of degenerative cervical myelopathy (DCM) is difficult in numerous patients due to the limited correlation of clinical symptoms, electrophysiology and MRI. This applies especially for early disease stages with mild symptoms or in uncertainty due to comorbidities. Conventional MRI myelopathy signs show a restricted sensitivity to clinical symptoms of at most 60%. It is desirable to select patients for surgical treatment as early as possible before irreversible neurological damage occurs. To improve treatment, a more reliable imaging is necessary. Microdiffusion imaging (MIDI) is an innovative MRI modality to depict tissue alterations within one voxel based on diffusion-weighted imaging (DWI) postprocessing. By separating the affected area into several mesoscopic compartments, pathological changes might be detected more sensitive through this subtle tissue resolution. We hypothesise, that MIDI shows myelopathic alterations more sensitive than conventional MRI and improves the correlation to functional impairment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>In this prospective, observational trial, 130 patients with a relevant degenerative cervical spinal stenosis receive MRI including MIDI and a standard clinical and electrophysiological assessment. Special subvoxel diffusion parameters are calculated. Clinical follow-ups are conducted after 3, 6 and with additional MRI and electrophysiology after 12 months. The primary endpoint is the sensitivity of MIDI to detect functional myelopathy defined by clinical and electrophysiological features correlated to conventional MRI myelopathy signs. Twenty healthy subjects will be included as negative control. The results will provide new insights into the development of mesoscopic spinal cord alterations in DCM associated to the clinical course. Aim is to improve the diagnostics of incipient myelopathy through this new modality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The study protocol is approved by the Ethics Committee of the University of Freiburg (reference 261\/17). The results will be published in a peer-reviewed journal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>DRKS00012962.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-029153","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T13:52:17Z","timestamp":1567518737000},"page":"e029153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Is microdiffusion imaging able to improve the detection of cervical myelopathy? Study protocol of a prospective observational trial (MIDICAM-Trial)"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-3161","authenticated-orcid":false,"given":"Marc","family":"Hohenhaus","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Helge","family":"Klingler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Hubbe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Reisert","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Physics, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Center \u2013 University of Freiburg, Faculty of Medicine, University of Freiburg, Germany, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"2025101811124403000_9.9.e029153.1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1177\/2192568217699208","article-title":"Current diagnosis and management of cervical spondylotic myelopathy","volume":"7","author":"Bakhsheshian","year":"2017","journal-title":"Global Spine Journal"},{"key":"2025101811124403000_9.9.e029153.2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000913"},{"key":"2025101811124403000_9.9.e029153.3","first-page":"97","article-title":"Surgical management of cervical degenerative disease: the evidence related to indications, impact, and outcome","volume":"11","author":"Fehlings","year":"2009","journal-title":"J Neurosurg"},{"key":"2025101811124403000_9.9.e029153.4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1468-1331.2008.02199.x","article-title":"How has electrophysiology changed the management of cervical spondylotic myelopathy?","volume":"15","author":"YL","year":"2008","journal-title":"Eur J Neurol"},{"key":"2025101811124403000_9.9.e029153.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00863.x"},{"key":"2025101811124403000_9.9.e029153.6","first-page":"112","article-title":"Clinical prognostic indicators of surgical outcome in cervical spondylotic myelopathy","volume":"11","author":"Holly","year":"2009","journal-title":"J Neurosurg"},{"key":"2025101811124403000_9.9.e029153.7","first-page":"104","article-title":"The natural history of cervical spondylotic myelopathy","volume":"11","author":"Matz","year":"2009","journal-title":"J Neurosurg"},{"key":"2025101811124403000_9.9.e029153.8","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1089\/neu.2016.4891","article-title":"Improved diagnosis of cervical spondylotic myelopathy with contact heat evoked potentials","volume":"34","author":"Jutzeler","year":"2017","journal-title":"J Neurotrauma"},{"key":"2025101811124403000_9.9.e029153.9","doi-asserted-by":"crossref","unstructured":"Meyer F , B\u00f6rm W , Thom\u00e9 C . 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