{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:35:30Z","timestamp":1769193330757,"version":"3.49.0"},"reference-count":21,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,5,31]]},"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ebola virus disease is one of the most devastating infectious diseases in the world with up to 90% case fatality observed. There are at least 13 candidate vaccines developed and being tested to prevent the occurrence of the Ebola virus disease. While none of these candidate vaccines has received regulatory approval for use, one candidate vaccine (rVSV\u0394G-ZEBOV-GP) has been granted access for emergency use. Two other candidate vaccines (GamEvac-Combi and Ad5-EBOV) have been licensed for emergency use in their countries of origin. The objective of this systematic review is to summarise the effects of the Ebola candidate vaccines in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will search for potentially eligible studies, with no language or date restrictions, in the Cochrane Central Register of Controlled Trials, PubMed, Scopus, the WHO International Clinical Trial Registry Platform, and reference lists of relevant publications. The Cochrane Database of Systematic Reviews (CDSR) and the Database of Abstracts of Reviews of Effect (DARE) will be searched for related reviews. Two review authors will independently screen search records, assess study eligibility, perform data extraction, and assess the risk of bias; and reconcile their findings. We will pool data from similar studies using Mantel-Haenszel\u2019s fixed-effect model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study is exempted from ethical consideration since the data collected are publicly available and at no point will confidential information from human participants be used. We will disseminate our results through publications in peer-reviewed journals and relevant conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42018110505.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-029617","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T10:37:24Z","timestamp":1562236644000},"page":"e029617","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of vaccines in protecting against Ebola virus disease: protocol for a systematic review"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-7318","authenticated-orcid":false,"given":"Lindi","family":"Mathebula","sequence":"first","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duduzile Edith","family":"Ndwandwe","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Pienaar","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-4779","authenticated-orcid":false,"given":"Charles Shey","family":"Wiysonge","sequence":"additional","affiliation":[{"name":"Cochrane South Africa, South African Medical Research Council, Tygerberg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"2025121411391348000_9.7.e029617.1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19790"},{"key":"2025121411391348000_9.7.e029617.2","first-page":"57","article-title":"General introduction into the Ebola virus biology and disease","volume":"54","author":"Zawili\u0144ska","year":"2014","journal-title":"Folia Med Cracov"},{"key":"2025121411391348000_9.7.e029617.3","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.685152"},{"key":"2025121411391348000_9.7.e029617.4","first-page":"49","article-title":"Ebola virus disease - pathogenesis, clinical presentation and management","volume":"54","author":"Bociaga-Jasik","year":"2014","journal-title":"Folia Med Cracov"},{"key":"2025121411391348000_9.7.e029617.5","first-page":"39","article-title":"Ebola haemorrhagic fever virus: pathogenesis, immune responses, potential prevention","volume":"54","author":"Marcinkiewicz","year":"2014","journal-title":"Folia Med Cracov"},{"key":"2025121411391348000_9.7.e029617.6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/1871526515666150320162259","article-title":"Ebola virus: current and future perspectives","volume":"15","author":"Jadav","year":"2015","journal-title":"Infect Disord Drug Targets"},{"key":"2025121411391348000_9.7.e029617.7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(18)31710-0","article-title":"Prevention of Ebola virus disease through vaccination: where we are in 2018","volume":"392","author":"L\u00e9vy","year":"2018","journal-title":"Lancet"},{"key":"2025121411391348000_9.7.e029617.8","unstructured":"Ebola vaccines \u2013 Background paper for SAGE deliberations. \"Update with the development of Ebola vaccines and implications of emerging evidence to inform future policy recommendations\". http:\/\/www.who.int\/immunization\/sage\/meetings\/2018\/october\/2_Ebola_SAGE2018Oct_BgDoc_20180919.pdf?ua=1 [Accessed Dec 2018]."},{"key":"2025121411391348000_9.7.e029617.9","unstructured":"World Health Organisation. 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