{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:08:00Z","timestamp":1769040480906,"version":"3.49.0"},"reference-count":105,"publisher":"BMJ","issue":"9","funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"crossref","award":["Grant for New Scholar (MRG6180069)"],"award-info":[{"award-number":["Grant for New Scholar (MRG6180069)"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,9,4]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Non-specific neck pain causes pain and disability and contributes substantial socioeconomic burden internationally. Up to 50% of adults experience neck pain annually, leading to reduced the quality of life. An active behavioural physiotherapy intervention (ABPI) may be feasible to manage patients with acute non-specific neck pain to prevent transition to chronicity. A recent pilot and feasibility trial investigating an acute whiplash-associated disorder population found potential value of the ABPI with 95% of participants fully recovered (Neck Disability Index: NDI \u22644, compared with 17% in the standard physiotherapy arm); supporting a definitive trial. Qualitative findings from the physiotherapists supported the potential of the ABPI in a non-specific neck pain population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Two phases: (1) Pragmatic cluster randomised double-blind, parallel 2-arm (ABPI vs standard physiotherapy intervention) pilot and feasibility trial to evaluate the procedures and feasibility of the ABPI for the management of acute non-specific neck pain. Six physiotherapy departments from six public hospitals in Thailand will be recruited and cluster randomised by a computer-generated randomisation sequence with block sampling. Sixty participants (30 each arm, 10 per hospital) will be assessed at baseline and 3 months following baseline for NDI, Numerical Rating Scale for pain intensity, cervical range of motion, fear-avoidance beliefs questionnaire and EuroQol-5 dimensions 5 levels outcomes, and (2) Embedded qualitative study using semistructured interviews to explore acceptability of the ABPI to participants (n=12) and physiotherapists (n=3). Descriptive analysis of the quantitative data and interpretative phenomenological analysis to code and analyse qualitative data (deductive and inductive) will inform feasibility for a future definitive trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This trial is approved by the Naresuan University Institutional Review Board (NUIRB_0380\/61).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number and status<\/jats:title>\n                    <jats:p>TCTR20180607001; Recruiting commenced 1 February 2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-029795","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T08:19:10Z","timestamp":1569917950000},"page":"e029795","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Pragmatic cluster randomised double-blind pilot and feasibility trial of an active behavioural physiotherapy intervention for acute non-specific neck pain: a mixed-methods protocol"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4115-704X","authenticated-orcid":false,"given":"Taweewat","family":"Wiangkham","sequence":"first","affiliation":[{"name":"Exercise and Rehabilitation Sciences Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand"},{"name":"Department of Physical Therapy, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sureeporn","family":"Uthaikhup","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-7669","authenticated-orcid":false,"given":"Alison B","family":"Rushton","sequence":"additional","affiliation":[{"name":"Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), University of Birmingham, Birmingham, UK"},{"name":"School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"2025120600244170000_9.9.e029795.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204431"},{"key":"2025120600244170000_9.9.e029795.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31460-X"},{"key":"2025120600244170000_9.9.e029795.3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00586-008-0624-y","article-title":"The burden and determinants of neck pain in the general population","volume":"17","author":"Hogg-Johnson","year":"2008","journal-title":"Eur Spine J"},{"key":"2025120600244170000_9.9.e029795.4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.spinee.2014.12.009","article-title":"Is neck pain associated with worse health-related quality of life 6 months later? a population-based cohort study","volume":"15","author":"Nolet","year":"2015","journal-title":"The Spine Journal"},{"key":"2025120600244170000_9.9.e029795.5","first-page":"E35","article-title":"Comprehensive review of epidemiology, scope, and impact of spinal pain","volume":"12","author":"Manchikanti","year":"2008","journal-title":"Pain Physician"},{"key":"2025120600244170000_9.9.e029795.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16885"},{"key":"2025120600244170000_9.9.e029795.7","unstructured":"Freeman B . 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