{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:38:50Z","timestamp":1787495930349,"version":"build-2736575974"},"reference-count":38,"publisher":"BMJ","issue":"10","funder":[{"name":"Alpe d'HuZes\/Dutch Cancer Society","award":["KUN 2013-5926"],"award-info":[{"award-number":["KUN 2013-5926"]}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["Project no. 11179"],"award-info":[{"award-number":["Project no. 11179"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,9,18]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with non-muscle-invasive bladder cancer (NMIBC) have a good survival but are at high risk for tumour recurrence and disease progression. It is important to identify lifestyle habits that may reduce the risk of recurrence and progression and improve health-related quality of life (HRQOL). This paper describes the rationale and design of the UroLife study. The main aim of this study is to evaluate whether lifestyle habits are related to prognosis and HRQOL in patients with NMIBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The UroLife study is a multicentre prospective cohort study among more than 1100 newly diagnosed patients with NMIBC recruited from 22 hospitals in the Netherlands. At 6\u2009weeks and 3, 15 and 51 months after diagnosis, participants fill out a general questionnaire, and questionnaires about their lifestyle habits and HRQOL. At 3, 15 and 51 months after diagnosis, information about fluid intake and micturition is collected with a 4-day diary. At 3 and 15 months after diagnosis, patients donate blood samples for DNA extraction and (dietary) biomarker analysis. Tumour samples are collected from all patients with T1 disease to assess molecular subtypes. Information about disease characteristics and therapy for the primary tumour and subsequent recurrences is collected from the medical records by the Netherlands Cancer Registry. Statistical analyses will be adjusted for age, gender, tumour characteristics and other known confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study protocol has been approved by the Committee for Human Research region Arnhem-Nijmegen (CMO 2013-494). Patients who agree to participate in the study provide written informed consent. The findings from our study will be disseminated through peer-reviewed scientific journals and presentations at (inter)national scientific meetings. Patients will be informed about the progress and results of this study through biannual newsletters and through the website of the study and of the bladder cancer patient association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-030396","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T15:37:45Z","timestamp":1571240265000},"page":"e030396","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["The UroLife study: protocol for a Dutch prospective cohort on lifestyle habits in relation to non-muscle-invasive bladder cancer prognosis and health-related quality of life"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6787-0404","authenticated-orcid":false,"given":"Liesbeth","family":"de Goeij","sequence":"first","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Westhoff","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Alfred","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Urology, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja KH","family":"Aben","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands"},{"name":"Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Kampman","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambertus ALM","family":"Kiemeney","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands"},{"name":"Department of Urology, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8178-2125","authenticated-orcid":false,"given":"Alina","family":"Vrieling","sequence":"additional","affiliation":[{"name":"Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"2025121602252416000_9.10.e030396.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025121602252416000_9.10.e030396.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.05.041"},{"key":"2025121602252416000_9.10.e030396.3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2015.06.045","article-title":"Eortc nomograms and risk groups for predicting recurrence, progression, and disease-specific and overall survival in non-muscle-invasive stage Ta-T1 urothelial bladder cancer patients treated with 1-3 years of maintenance Bacillus Calmette-Gu\u00e9rin","volume":"69","author":"Cambier","year":"2016","journal-title":"Eur Urol"},{"key":"2025121602252416000_9.10.e030396.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-009-0395-z"},{"key":"2025121602252416000_9.10.e030396.5","doi-asserted-by":"crossref","unstructured":"Schmidt S , Franc\u00e9s A , Lorente Garin JA , et al . Quality of life in patients with non-muscle-invasive bladder cancer: one-year results of a multicentre prospective cohort study. Urol Oncol 2015;33 doi:10.1016\/j.urolonc.2014.09.012","DOI":"10.1016\/j.urolonc.2014.09.012"},{"key":"2025121602252416000_9.10.e030396.6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.0638"},{"key":"2025121602252416000_9.10.e030396.7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.mcna.2017.06.004","article-title":"Diet, physical activity, and body weight in cancer survivorship","volume":"101","author":"Mehra","year":"2017","journal-title":"Med Clin North Am"},{"key":"2025121602252416000_9.10.e030396.8","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw044"},{"key":"2025121602252416000_9.10.e030396.9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.eururo.2018.09.001","article-title":"Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018","volume":"74","author":"Cumberbatch","year":"2018","journal-title":"Eur Urol"},{"key":"2025121602252416000_9.10.e030396.10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119313","article-title":"Obesity and risk of bladder cancer: a dose-response meta-analysis of 15 cohort studies","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"2025121602252416000_9.10.e030396.11","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/bjc.2014.77","article-title":"The association between physical activity and bladder cancer: systematic review and meta-analysis","volume":"110","author":"Keimling","year":"2014","journal-title":"Br J Cancer"},{"key":"2025121602252416000_9.10.e030396.12","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research . Continuous update project expert report 2018: diet, nutrition, physical activity and bladder cancer, 2018. Available: https:\/\/www.wcrf.org\/dietandcancer"},{"key":"2025121602252416000_9.10.e030396.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.06.010"},{"key":"2025121602252416000_9.10.e030396.14","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.18632\/oncotarget.13606","article-title":"Association of smoking status with prognosis in bladder cancer: a meta-analysis","volume":"8","author":"Hou","year":"2017","journal-title":"Oncotarget"},{"key":"2025121602252416000_9.10.e030396.15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/BLC-170147","article-title":"Body mass index, diet-related factors, and bladder cancer prognosis: a systematic review and meta-analysis","volume":"4","author":"Westhoff","year":"2018","journal-title":"Bladder Cancer"},{"key":"2025121602252416000_9.10.e030396.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.01.089"},{"key":"2025121602252416000_9.10.e030396.17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/cncr.28394","article-title":"Body mass and smoking are modifiable risk factors for recurrent bladder cancer","volume":"120","author":"Wyszynski","year":"2014","journal-title":"Cancer"},{"key":"2025121602252416000_9.10.e030396.18","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1013-1"},{"key":"2025121602252416000_9.10.e030396.19","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.eursup.2009.06.010","article-title":"Recurrence, progression, and follow-up in Non\u2013Muscle-Invasive bladder cancer","volume":"8","author":"van der Heijden","year":"2009","journal-title":"European Urology Supplements"},{"key":"2025121602252416000_9.10.e030396.20","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0077-T"},{"key":"2025121602252416000_9.10.e030396.21","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.eururo.2015.02.021","article-title":"A molecular pathologic framework for risk stratification of stage T1 urothelial carcinoma","volume":"68","author":"Patschan","year":"2015","journal-title":"Eur Urol"},{"key":"2025121602252416000_9.10.e030396.22","doi-asserted-by":"crossref","unstructured":"Jung A , Nielsen ME , Crandell JL , et al . Quality of life in non-muscle-invasive bladder cancer survivors. Cancer Nurs 2019;42 doi:10.1097\/NCC.0000000000000606","DOI":"10.1097\/NCC.0000000000000606"},{"key":"2025121602252416000_9.10.e030396.23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3233\/BLC-160051","article-title":"Pursuing quality in the application of bladder cancer quality of life research","volume":"2","author":"Mohamed","year":"2016","journal-title":"Bladder Cancer"},{"key":"2025121602252416000_9.10.e030396.24","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s11764-016-0533-8","article-title":"Lifestyle factors and health-related quality of life in bladder cancer survivors: a systematic review","volume":"10","author":"Gopalakrishna","year":"2016","journal-title":"J Cancer Surviv"},{"key":"2025121602252416000_9.10.e030396.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.04.034"},{"key":"2025121602252416000_9.10.e030396.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00220-8"},{"key":"2025121602252416000_9.10.e030396.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.05.005"},{"key":"2025121602252416000_9.10.e030396.28","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-9-141","article-title":"Reliability and validity of the short questionnaire to assess health-enhancing physical activity (squash) in patients after total hip arthroplasty","volume":"9","author":"Wagenmakers","year":"2008","journal-title":"BMC Musculoskelet Disord"},{"key":"2025121602252416000_9.10.e030396.29","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511000067"},{"key":"2025121602252416000_9.10.e030396.30","unstructured":"NEVO . NEVO-tabel: Dutch food composition database. Den Haag RIVM\/Voedingscentrum; 2011."},{"key":"2025121602252416000_9.10.e030396.31","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"2025121602252416000_9.10.e030396.32","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.eururo.2014.02.034","article-title":"Validation and reliability testing of the EORTC QLQ-NMIBC24 questionnaire module to assess patient-reported outcomes in non-muscle-invasive bladder cancer","volume":"66","author":"Blazeby","year":"2014","journal-title":"Eur Urol"},{"key":"2025121602252416000_9.10.e030396.33","doi-asserted-by":"crossref","DOI":"10.1007\/s11934-018-0853-5","article-title":"Molecular characterization of bladder cancer","volume":"19","author":"Chandrasekar","year":"2018","journal-title":"Curr Urol Rep"},{"key":"2025121602252416000_9.10.e030396.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"2025121602252416000_9.10.e030396.35","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(90)90005-M"},{"key":"2025121602252416000_9.10.e030396.36","unstructured":"Dupont WD , Plummer WD . Ps: power and sample size calculation. Available: http:\/\/biostat.mc.vanderbilt.edu\/wiki\/Main\/PowerSampleSize [Accessed 16 Jan 2019]."},{"key":"2025121602252416000_9.10.e030396.37","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"2025121602252416000_9.10.e030396.38","unstructured":"Faul F , Erdfelder E , Buchner A , et al . G*Power: statistical power analyses for windows and MAC. Available: http:\/\/www.gpower.hhu.de [Accessed 16 Jan 2019]."}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2019-030396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:25:37Z","timestamp":1765880737000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2019-030396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,16]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bmjopen-2019-030396"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2019-030396","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}