{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:06:04Z","timestamp":1767859564854,"version":"3.49.0"},"reference-count":15,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,8,7]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Genomics and personalised medicine are increasingly relevant for patients with gastroenterological conditions. We aim to capture the current state of genomics training in gastroenterology to review current understanding, clinical experience and long-term educational needs of UK trainees.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>A web-based nationwide survey of all UK gastroenterology specialty trainees was conducted in 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>100 trainees (14% of UK gastroenterology trainees) completed this survey. Only 9% and 16% of respondents believe that their local training programme adequately prepares them for the future clinical practice using genomic medicine and personalised medicine, respectively. Barriers identified include the need for greater trainee education (95%), inadequate clinical guidance to base interventions on the results of genomic testing (53%), concerns over misinterpretation by patients (43%) and overuse\/misuse of testing by clinicians (34%).<\/jats:p><jats:p>Survey respondents felt prepared to perform HFE genotyping (98%), assess TPMT status (97%) and interpret HLA subtyping for suspected coeliac disease (85%). However, only a minority felt prepared to perform the following investigations: polyposis screening (34%), hereditary pancreatitis screening (30%), testing for Lynch yndrome (33%) and KRAS testing for colorectal cancer (20%).<\/jats:p><jats:p>Most respondents would support holding dedicated training days on genomic medicine (83%), formal training provisions for the mainstreaming of genomic testing (64%), an update to the UK gastroenterology specialty training curriculum and examinations (57%) and better-defined referral pathways for local genomic services (91%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most gastroenterology trainees in this survey feel ill equipped to practise genomic and personalised medicine as consultants. We propose specific revisions to the UK gastroenterology specialty curriculum that addresses trainees needs.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2019-030505","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T14:25:23Z","timestamp":1571754323000},"page":"e030505","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Mainstreaming of genomic medicine in gastroenterology, present and future: a nationwide survey of UK gastroenterology trainees"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-3459","authenticated-orcid":false,"given":"Ibrahim","family":"Al Bakir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Malcolm","family":"Sebepos-Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J","family":"Monahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"2024052014233037000_9.10.e030505.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2014.07.001"},{"key":"2024052014233037000_9.10.e030505.2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.mayocp.2017.03.002","article-title":"Individualized medicine in gastroenterology and hepatology","volume":"92","author":"Stephens","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"2024052014233037000_9.10.e030505.3","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.k1687","article-title":"The 100\u2009000 Genomes Project: bringing whole genome sequencing to the NHS","volume":"361","author":"Turnbull","year":"2018","journal-title":"BMJ"},{"key":"2024052014233037000_9.10.e030505.4","unstructured":"England NHS . Improving outcomes through personalised medicine, 2016."},{"key":"2024052014233037000_9.10.e030505.5","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/gim.2017.247","article-title":"Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature","volume":"20","author":"Schwarze","year":"2018","journal-title":"Genet Med"},{"key":"2024052014233037000_9.10.e030505.6","unstructured":"Joint Royal Colleges of Physicians Training Board . Specialty training curriculum for gastroenterology, 2010."},{"key":"2024052014233037000_9.10.e030505.7","unstructured":"Joint Royal Colleges of Physicians Training Board . Specialty training curriculum for cardiology, 2010."},{"key":"2024052014233037000_9.10.e030505.8","unstructured":"Royal College of Radiology . Specialty training curriculum for clinical oncology, 2016."},{"key":"2024052014233037000_9.10.e030505.9","unstructured":"SurveyMonkey Inc . San Mateo. California, USA."},{"key":"2024052014233037000_9.10.e030505.10","unstructured":"Federation of the Royal Colleges of Physicians of the UK . Census (UK consultants and higher specialty trainees), 2016-2017."},{"key":"2024052014233037000_9.10.e030505.11","unstructured":"Burton H , Hall A , Kroese M , et al . Genomics in mainstream clinical pathways, 2017. Available: http:\/\/www.phgfoundation.org\/documents\/PHGF-Genomics-in-mainstream-clinical-pathways.pdf [Accessed 1 May 2018]."},{"key":"2024052014233037000_9.10.e030505.12","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2013-100362"},{"key":"2024052014233037000_9.10.e030505.13","unstructured":"National Institute for Health and Care Excellence (NICE) . Molecular testing strategies for Lynch syndrome in people with colorectal cancer, 2017."},{"key":"2024052014233037000_9.10.e030505.14","unstructured":"Joint Royal College of Physicians Training Board - Workplace Based Assessment. Available: https:\/\/www.jrcptb.org.uk\/assessment\/workplace-based-assessment [Accessed 23 Aug 2018]."},{"key":"2024052014233037000_9.10.e030505.15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy170"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2019-030505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T21:23:43Z","timestamp":1716240223000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2019-030505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,22]]},"published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1136\/bmjopen-2019-030505"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2019-030505","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}