{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:28:09Z","timestamp":1773260889093,"version":"3.50.1"},"reference-count":28,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/501100012266","name":"Norwegian Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012266","id-type":"DOI","asserted-by":"crossref"}]},{"name":"South-Eastern Norway Regional Authority"},{"DOI":"10.13039\/501100008568","name":"Norske Kvinners Sanitetsforening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008568","id-type":"DOI","asserted-by":"publisher"}]},{"name":"People with Heart and Lung Diseases"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,4,10]]},"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with various inflammatory rheumatic diseases (IRDs) have increased risk of atherothrombotic disease. Lipoprotein (a) (Lp(a)) is a risk factor for atherosclerosis but its role in IRD with accompanying coronary artery disease (CAD) is still unclear. We aimed to examine if serum Lp(a) levels differed between CAD patients with and without accompanying IRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional observational, patient-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Referred centre for coronary artery bypass grafting in the South Eastern part of Norway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>67 CAD patients with IRD (CAD\/IRD) and 52 CAD patients without IRD (CAD\/non-IRD). All patients were Caucasians, aged &gt;18 years, without any clinically significant infection or malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lp(a) levels in serum were analysed by particle enhanced immunoturbidimetric assay, and Lp(a) levels were related to clinical and biochemical characteristics of the patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found no differences in serum levels of Lp(a) between CAD patients with and without IRD. In general, we found that Lp(a) correlated poorly with clinical and biochemical parameters including C reactive protein with the same pattern in the CAD\/non-IRD and CAD\/IRD groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data do not support a link between inflammation and Lp(a) levels in CAD and in general Lp(a) levels were not correlated with other risk factors for cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-030651","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T06:55:23Z","timestamp":1557557723000},"page":"e030651","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: a cross-sectional study"],"prefix":"10.1136","volume":"9","author":[{"given":"Sverre","family":"Holm","sequence":"first","affiliation":[{"name":"Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway"},{"name":"Rheumatology Department, Hospital for Rheumatic Diseases, Lillehammer, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingvild","family":"Oma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sykehuset Innlandet HF Divisjon Lillehammer, Lillehammer, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor-Arne","family":"Hagve","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"},{"name":"Division of Diagnostics and Technology, Akershus University Hospital, Lorenskog, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Saatvedt","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Brosstad","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway"},{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knut","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital for Rheumatic Diseases, Lillehammer, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Rydningen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Feiring Heart Clinic, Feiring, 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