{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:17:00Z","timestamp":1770707820626,"version":"3.49.0"},"reference-count":34,"publisher":"BMJ","issue":"9","funder":[{"name":"This analysis was funded by an unconditional grant from Angelini SpA"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,8,13]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the analysis is to assess the organisational and economic consequences of adopting an early discharge strategy for the treatment of acute bacterial skin and skin structure infection (ABSSSI) and osteomyelitis within infectious disease departments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Infectious disease departments in Greece, Italy and Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>No patients were involved in the analysis performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>An analytic framework was developed to consider two alternative scenarios: standard hospitalisation care or an early discharge strategy for patients hospitalised due to ABSSSI and osteomyelitis, from the perspective of the National Health Services of Greece, Italy and Spain. The variables considered were: the number of annual hospitalisations eligible for early discharge, the antibiotic treatments considered (ie, oral antibiotics and intravenous long-acting antibiotics), diagnosis-related group (DRG) reimbursements, number of days of hospitalisation, incidence and costs of hospital-acquired infections, additional follow-up visits and intravenous administrations. Data were based on published literature and expert opinions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Number of days of hospitalisation avoided and direct medical costs avoided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The total number of days of hospitalisation avoided on a yearly basis would be between 2216 and 5595 in Greece (\u22128\/\u221221 hospital beds), between 15\u2009848 and 38\u2009444 in Italy (\u221257\/\u2212135 hospital beds) and between 7529 and 23\u2009520 in Spain (\u221227\/\u221285 hospital beds). From an economic perspective, the impact of the early discharge scenario is a reduction between \u20ac45 036 and \u20ac149 552 in Greece, a reduction between \u20ac182 132 and \u20ac437 990 in Italy and a reduction between \u20ac292 284 and \u20ac884 035 in Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The early discharge strategy presented would have a positive organisational impact on National Health Services, leading to potential savings in beds, and to a reduction of hospital-acquired infections and costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-031356","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T17:06:13Z","timestamp":1568307973000},"page":"e031356","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Organisational and financial consequences of the early discharge of patients treated for acute bacterial skin and skin structure infection and osteomyelitis in infectious disease departments in Greece, Italy and Spain: a scenario analysis"],"prefix":"10.1136","volume":"9","author":[{"given":"Umberto","family":"Restelli","sequence":"first","affiliation":[{"name":"Center for Health Economics, Social and Health Care Management, LIUC\u2013Universit\u00e0 Cattaneo, Castellanza, Italy"},{"name":"School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"Center for Health Economics, Social and Health Care Management, LIUC\u2013Universit\u00e0 Cattaneo, Castellanza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Croce","sequence":"additional","affiliation":[{"name":"Center for 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