{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:28:34Z","timestamp":1791415714986,"version":"4.3.3"},"reference-count":22,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,10,18]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Septic shock is a life-threatening infection frequently responsible for hospital admissions or may be acquired as nosocomial infection in hospitalized patients with resultant significant morbidity and mortality . There is a dearth of data on a r\u00e9sum\u00e9 and meta-analysis on the global epidemiology of this potentially deadly condition. Therefore, we propose the first systematic review to synthesize existing data on the global incidence, prevalence and case fatality rate of septic shock worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We will include cross-sectional, case-control and cohort studies reporting on the incidence, and case fatality rate of septic shock. Electronic databases including PubMed, Embase, WHO Global Health Library and Web of Science will be searched for relevant records published between 1 January 2000 and 31 August 2019. Independents reviewers will perform study selection and data extraction, as well as assessment of methodological quality of included studies. Appropriate meta-analysis will then be used to pool studies judged to be clinically homogenous. Egger\u2019s test and funnel plots will be used to detect publication bias. Findings will be reported and compared by human development level of countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Being a review, ethical approval is not required as it was obtained in the primary study which will make up the review. This review is expected to provide relevant data to help in evaluating the burden of septic shock in the general population. The overall findings of this research will be published in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42019129783.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-032289","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T13:45:24Z","timestamp":1573739124000},"page":"e032289","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Global epidemiology of septic shock: a protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"9","author":[{"given":"Frank Leonel","family":"Tianyi","sequence":"first","affiliation":[{"name":"Department of General Medicne, Mayo Darle Sub-Divisional Hospital, Banyo, Adamawa, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2467","authenticated-orcid":false,"given":"Joel Noutakdie","family":"Tochie","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-4331","authenticated-orcid":false,"given":"Celestin","family":"Danwang","sequence":"additional","affiliation":[{"name":"School of Public Health, Universite Libre de Bruxelles, Bruxelles, Belgium"},{"name":"Department of Surgery and sub-Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aime","family":"Mbonda","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Social Insurance Fond Hospital, Yaounde, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazou N","family":"Temgoua","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and sub-Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvester Yari","family":"Mapoh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Louisiana, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Njinkeng J","family":"Nkemngu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Tallah","sequence":"additional","affiliation":[{"name":"Cameroon Coalition Against Malaria, Yaounde, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-6279","authenticated-orcid":false,"given":"Jean Joel","family":"Bigna","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Centre Pasteur of Cameroon, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"2025120600570399000_9.11.e032289.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"2025120600570399000_9.11.e032289.2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/imj.14199","article-title":"Sepsis and septic shock: current approaches to management","volume":"49","author":"Thompson","year":"2019","journal-title":"Intern Med J"},{"key":"2025120600570399000_9.11.e032289.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"2025120600570399000_9.11.e032289.4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5804"},{"key":"2025120600570399000_9.11.e032289.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"2025120600570399000_9.11.e032289.6","doi-asserted-by":"crossref","unstructured":"Sakr Y , Jaschinski U , Wittebole X , et al . 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