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To further understand FASD in adulthood is a major public health interest.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe the clinical characteristics of young adults with FASD adopted from orphanages to a socially more favourable and stable rearing environment as children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective observational cohort study<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Western Sweden<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>A population-based cohort of 37 adoptees diagnosed with FASD in childhood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Outcome measures<\/jats:title>\n                  <jats:p>Assessment consisted of clinical evaluations of social, medical, psychiatric, neuropsychological, adaptive and ophthalmological status by a physician, ophthalmologist, orthoptist and psychologist.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 37 adoptees with FASD, 36 (15 females) were evaluated at a median age of 22 years (range 18\u201328) and a mean follow-up time of 15.5 years (range 13\u201317). Twenty (56%) were dependent on social support. Sexual victimisation was reported by nine (26%). In 21 individuals with fetal alcohol syndrome, growth restriction in height and head circumference of approximately \u22121.8 SD persisted into adulthood. Of 32 examined, 22 (69%) had gross motor coordination abnormalities. High blood pressure was measured in nine (28%). Ophthalmological abnormalities were found in 29 of 30 (97%). A median IQ of 86 in childhood had declined significantly to 71 by adulthood (mean difference: 15.5; 95% CI 9.5\u201321.4). Psychiatric disorders were diagnosed in 88%, most commonly attention deficit hyperactivity disorder (70%). Three or more disorders were diagnosed in 48%, and 21% had attempted suicide. The median Clinical Global Impression-Severity score was 6 = \u2018severely ill\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Major cognitive impairments, psychiatric morbidity, facial dysmorphology, growth restriction and ophthalmological abnormalities accompanies FASD in adulthood. Recognition of FASD in childhood warrants habilitation across the lifespan.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-032407","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T10:25:21Z","timestamp":1572431121000},"page":"e032407","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Fetal alcohol spectrum disorders from childhood to adulthood: a Swedish population-based naturalistic cohort study of adoptees from Eastern Europe"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-8221","authenticated-orcid":false,"given":"Valdemar","family":"Landgren","sequence":"first","affiliation":[{"name":"Psychiatry, Skaraborg Hospital Sk\u00f6vde, Sk\u00f6vde, Sweden"},{"name":"Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Svensson","sequence":"additional","affiliation":[{"name":"Pediatrics, Skaraborg Hospital Mariestad, Mariestad, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Gyllencreutz","sequence":"additional","affiliation":[{"name":"Ophthalmology, Skaraborg Hospital Sk\u00f6vde, Sk\u00f6vde, Sweden"},{"name":"Clinical Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Aring","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden"},{"name":"Ophthalmology, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita Andersson","family":"Gr\u00f6nlund","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden"},{"name":"Ophthalmology, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Landgren","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden"},{"name":"Pediatrics, Skaraborg Hospital Mariestad, Mariestad, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2025101814465741000_9.10.e032407.1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.71"},{"key":"2025101814465741000_9.10.e032407.2","first-page":"476","article-title":"Les enfants de parents alcooliques. anomalies observees. 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