{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:40:07Z","timestamp":1760834407433,"version":"build-2065373602"},"reference-count":26,"publisher":"BMJ","issue":"9","funder":[{"name":"Dr. Adam Linton Chair in Kidney Health Analytics"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-CEBA-61355"],"award-info":[{"award-number":["FDN-CEBA-61355"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009026","name":"Smith & Nephew","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009026","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CIHR Clinician Investigator Award"},{"DOI":"10.13039\/100023459","name":"Ontario SPOR Support Unit","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100023459","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,8,29]]},"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>Hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) is a multicentre, international, parallel-group randomised controlled trial (RCT). Patients who suffer a hip fracture are randomly allocated to either accelerated medical assessment and surgical repair with a goal of surgery within 6\u2009hours of diagnosis or standard care where a repair typically occurs 24 to 48\u2009hours after diagnosis. The primary outcome of this substudy is the development of AKI within 7 days of randomisation. We anticipate at least 1998 patients will participate in this substudy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>We obtained ethics approval for additional serum creatinine recordings in consecutive patients enrolled at 70 participating centres. All patients provide consent before randomisation. We anticipate reporting substudy results by 2021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02027896\">NCT02027896<\/jats:ext-link>; Pre-results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-033150","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T11:47:21Z","timestamp":1569325641000},"page":"e033150","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial"],"prefix":"10.1136","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct02027896","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-7612","authenticated-orcid":false,"given":"Flavia K","family":"Borges","sequence":"first","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"},{"name":"Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Devereaux","sequence":"additional","affiliation":[{"name":"Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada"},{"name":"Departments of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meaghan","family":"Cuerden","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Guerra-Farf\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, University Hospital Vall d'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameen","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alben","family":"Sigamani","sequence":"additional","affiliation":[{"name":"Clinical Research, Narayana Hrudayalaya Limited, Bangalore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masood","family":"Umer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Neary","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Tiboni","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mmampapatla Thomas","family":"Ramokgopa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa"},{"name":"Department of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag","family":"Sancheti","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Sancheti Institute for Orthopaedics & Rehabilitation, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby","family":"John","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Christian Medical College and Hospital Ludhiana, Ludhiana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AbdelRahman","family":"Lawendy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Western University, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-6887","authenticated-orcid":false,"given":"Mariano","family":"Balaguer-Castro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed I3PT, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Department of Surgery and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"\u015al\u0119czka","sequence":"additional","affiliation":[{"name":"Orthopaedic Department, SPZOZ, Myslenice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamer","family":"Nabi Nur","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin C A","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen's University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Feibel","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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