{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:33:42Z","timestamp":1770741222377,"version":"3.49.0"},"reference-count":46,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,1,7]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1\u2009year of follow-up in subjects with pre-diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>General population from a semi-rural area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of undiagnosed diabetes was 20, 3.4% (95% CI 2.6 to 4.2) and that of pre-diabetes was 229, 39.3% (37.3 to 41.3). Among those with pre-diabetes, 18.3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to &lt;126\u2009mg\/dL), 58.1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5.7 to &lt;6.5) and 23.6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41.6%(37.8 to 45.4) returned to normoglycaemia, 57.6% (57.8 to 61.4) persisted in pre-diabetes and 0.6% (0 to 1.2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1.033; 1.011 to 1.056), higher physical activity (0.546; 0.360 to 0.827), body mass index (1.121; 1.029 to 1.222) and a family history of diabetes (1.543; 1.025 to 2.323). The variables significantly associated with glycaemic normalisation were older age (0.948; 0.916 to 0.982) and body mass index (0.779; 0.651 to 0.931).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3.4% and that of pre-diabetes was 39.3%. After a 1-year follow-up, a small proportion of subjects (0.6%) with pre-diabetes progressed to diabetes, while a high proportion (41.6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass index.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-033332","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T04:34:32Z","timestamp":1579581272000},"page":"e033332","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia"],"prefix":"10.1136","volume":"10","author":[{"given":"Mireia","family":"Falguera","sequence":"first","affiliation":[{"name":"Primary Health Care Centre Cervera, Ger\u00e8ncia d'Atenci\u00f3 Primaria, Institut Catal\u00e0 de la Salut, Lleida, Spain"},{"name":"Department of Medicine, University of Lleida & Biomedical Research Institute of Lleida, Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Bel\u00e9n","family":"Vilanova","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Lleida & Biomedical Research Institute of Lleida, Lleida, Spain"},{"name":"Primary Health Care Centre Igualada Nord, Ger\u00e8ncia d'Atenci\u00f3 Primaria, Institut Catal\u00e0 de la Salut, Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Alcubierre","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Avantmedic, Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minerva","family":"Granado-Casas","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Lleida & Biomedical Research Institute of Lleida, Lleida, Spain"},{"name":"Department of Endocrinology & Nutrition, University Hospital Germans Trias I Pujol & Health Sciences Research Institute, Badalona, 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