{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:35:15Z","timestamp":1787016915914,"version":"build-2736575974"},"reference-count":35,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/501100004726","name":"Ministry of Health","doi-asserted-by":"publisher","award":["Health System Impact Fellowship 18183"],"award-info":[{"award-number":["Health System Impact Fellowship 18183"]}],"id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000037","name":"Institute of Health Services and Policy Research","doi-asserted-by":"publisher","award":["Health System Impact Fellowship HI7-160383"],"award-info":[{"award-number":["Health System Impact Fellowship HI7-160383"]}],"id":[{"id":"10.13039\/501100000037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["National Research Service Award 1F31HD086970-01A1"],"award-info":[{"award-number":["National Research Service Award 1F31HD086970-01A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","award":["Research Trainee Award 17934"],"award-info":[{"award-number":["Research Trainee Award 17934"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2019,11,20]]},"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate absolute risks of obstetric outcomes in the USA according to maternal age at first birth from age 15 to 45 separately by maternal race.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Population-based cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Vital statistics Birth Cohort-Linked Birth- Infant Death Data Files and Fetal Death Data Files in the USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>16\u2009514\u2009849 births to nulliparous women from 2004 to 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>We estimated absolute risks of obstetric outcomes (multiple gestations, caesarean delivery, early and late preterm birth, small for gestational age birth, stillbirth, neonatal mortality, postneonatal infant mortality) at each year of maternal age from 15 to 45 years using logistic regression in the overall population and stratified by maternal race. We modelled maternal age flexibly to allow curvilinear shapes and plotted risk curves for each outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the overall population, multiple gestations, caesarean delivery and stillbirth risks were lowest at young maternal ages with linear or quadratic increases with age. Curves for preterm birth, small for gestational age, neonatal mortality and postneonatal mortality were u or j shaped, with nadirs between 20 and 29 years, and elevated risks at both younger and older maternal ages. In race-stratified analyses, the shapes of the curves were generally similar across races. Risks increased for all women for all outcomes after age 30. However, increased risks at young maternal ages were most pronounced for white and Asian\/Pacific Islander women, for whom young childbearing was least common. Conversely, risks at older ages were more pronounced for Black and American Indian\/Alaska Native women, for whom delayed childbearing was least common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings confirm risks associated with first births to women younger than 20 and older than 30 years, provide easily interpretable risk curves and illuminate variability in these relationships across categories of maternal race in the USA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-033697","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:35:22Z","timestamp":1576474522000},"page":"e033697","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Variation in relationships between maternal age at first birth and pregnancy outcomes by maternal race: a population-based cohort study in the United States"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3536-0498","authenticated-orcid":false,"given":"Laura","family":"Schummers","sequence":"first","affiliation":[{"name":"Family Practice, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele R","family":"Hacker","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige L","family":"Williams","sequence":"additional","affiliation":[{"name":"Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"},{"name":"Biostatistics, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Hutcheon","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J","family":"Vanderweele","sequence":"additional","affiliation":[{"name":"Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"},{"name":"Biostatistics, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"McElrath","sequence":"additional","affiliation":[{"name":"Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Hernandez-Diaz","sequence":"additional","affiliation":[{"name":"Epidemiology, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"2025101814340870000_9.12.e033697.1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186287","article-title":"Advanced maternal age and adverse pregnancy outcomes: a systematic review and meta-analysis","volume":"12","author":"Lean","year":"2017","journal-title":"PLoS One"},{"key":"2025101814340870000_9.12.e033697.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000163256.83313.36"},{"key":"2025101814340870000_9.12.e033697.3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/1471-0528.12659","article-title":"Advanced maternal age and pregnancy outcomes: a multicountry assessment","volume":"121","author":"Laopaiboon","year":"2014","journal-title":"Brit J Obstet Gynaec"},{"key":"2025101814340870000_9.12.e033697.4","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/aogs.13020","article-title":"At what age does the risk for adverse maternal and infant outcomes increase? 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