{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:44:38Z","timestamp":1787762678916,"version":"build-2784847793"},"reference-count":28,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diverticulitis is among the most common abdominal disorders. The best treatment strategy for this complicated disease as well as for recurrent stages is still under debate. Moreover, little knowledge exists regarding the effect of different therapeutic strategies on the health-related quality of life (HrQoL). Therefore, the PREDIC-DIV (PREDICtors for health-related quality of life after elective sigmoidectomy\nfor DIVerticular disease) study aims to assess predictors of a change in HrQoL in patients after elective sigmoidectomy for diverticular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A prospective multicentre transnational observational study was started in November 2017. Patients undergoing elective sigmoid resection for diverticular disease were included. Primary outcome includes HrQoL 6\u2009months postoperatively, staged by the Gastrointestinal Quality of Life Index (GIQLI). Secondary outcomes include HrQoL 6\u2009months after sigmoidectomy, assessed using the Short Form 36 Questionnaire and a custom-made Visual Analogue Scale-based inventory; HrQoL after 12 and 24 months; postoperative morbidity; mortality; influence of surgical technique (conventional laparoscopic multiport operation vs robotic approach); histological grading of inflammation and morphological characteristics of the bowel wall in the resected specimen; postoperative functional changes (faecal incontinence, faecal urge, completeness of emptying, urinary incontinence, sexual function); disease-specific healthcare costs; and changes in economic productivity, measured by the iMTA Productivity Cost Questionnaire. The total follow-up will be 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      The protocol was approved by the medical ethical committee of the Bavarian Medical Council (report identification number: 2017-177). The study was conducted in accordance with the Declaration of Helsinki. The findings of this study will be submitted to a peer-reviewed journal (\n                      <jats:italic>BMJ Open<\/jats:italic>\n                      ,\n                      <jats:italic>Annals of Surgery<\/jats:italic>\n                      ,\n                      <jats:italic>British Journal of Surgery<\/jats:italic>\n                      ,\n                      <jats:italic>Diseases of the Colon and the Rectum<\/jats:italic>\n                      ). Abstracts will be submitted to relevant national and international conferences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      The study is registered with the ClinicalTrials.gov register as\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\" xlink:href=\"NCT03527706\">NCT03527706<\/jats:ext-link>\n                      ; Pre-results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-034385","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T16:25:14Z","timestamp":1585067114000},"page":"e034385","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["PREDICtors for health-related quality of life after elective sigmoidectomy for DIVerticular disease: the PREDIC-DIV study protocol of a prospective multicentric transnational observational study"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct03527706","registry":"10.18810\/clinical-trials-gov","type":"preResults"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-2366","authenticated-orcid":false,"given":"Maximilian","family":"Sohn","sequence":"first","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Agha","sequence":"additional","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igors","family":"Iesalnieks","sequence":"additional","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Bremer","sequence":"additional","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Trum","sequence":"additional","affiliation":[{"name":"Klinikum Dritter Orden, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Cerbo","sequence":"additional","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Nerlich","sequence":"additional","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Lotz","sequence":"additional","affiliation":[{"name":"M\u00fcnchen Klinik Bogenhausen, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Klieser","sequence":"additional","affiliation":[{"name":"Salzburger Universit\u00e4tsklinikum, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Hochrein","sequence":"additional","affiliation":[{"name":"OCM Clinic, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schredl","sequence":"additional","affiliation":[{"name":"Salzburger Universit\u00e4tsklinikum, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariya","family":"Kalcheva","sequence":"additional","affiliation":[{"name":"Salzburger Universit\u00e4tsklinikum, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Salzburger Universit\u00e4tsklinikum, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Presl","sequence":"additional","affiliation":[{"name":"Salzburger Universit\u00e4tsklinikum, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"2025120519135908000_10.3.e034385.1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/ajg.2015.302","article-title":"Temporal trends in the incidence and natural history of diverticulitis: a population-based study","volume":"110","author":"Bharucha","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"2025120519135908000_10.3.e034385.2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000894"},{"key":"2025120519135908000_10.3.e034385.3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000367625","article-title":"German Society for gastroenterology, digestive and metabolic diseases and the German Society for general and visceral surgery. diverticular disease: guidelines of the German Society for gastroenterology, digestive and metabolic diseases and the German Society for general and visceral surgery","volume":"90","author":"Kruis","year":"2014","journal-title":"Digestion"},{"key":"2025120519135908000_10.3.e034385.4","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000075"},{"key":"2025120519135908000_10.3.e034385.5","first-page":"663","article-title":"S2k guidelines diverticular disease\/diverticulitis]","volume":"52","author":"Leifeld","year":"2014","journal-title":"Z F\u00fcr Gastroenterol"},{"key":"2025120519135908000_10.3.e034385.6","article-title":"Danish national guidelines for treatment of diverticular disease","volume":"59","author":"Andersen","year":"2012","journal-title":"Dan Med J"},{"key":"2025120519135908000_10.3.e034385.7","doi-asserted-by":"publisher","DOI":"10.1159\/000354035"},{"key":"2025120519135908000_10.3.e034385.8","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820229"},{"key":"2025120519135908000_10.3.e034385.9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00384-015-2176-z","article-title":"The relation between quality of life and histopathology in diverticulitis; can we predict specimen-related outcome?","volume":"30","author":"Stam","year":"2015","journal-title":"Int J Colorectal Dis"},{"key":"2025120519135908000_10.3.e034385.10","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2482-10-25","article-title":"Direct trial. diverticulitis recurrences or continuing symptoms: operative versus conservative treatment. A multicenter randomised clinical trial","volume":"10","author":"van de Wall","year":"2010","journal-title":"BMC Surg"},{"key":"2025120519135908000_10.3.e034385.11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/SLA.0b013e318195c5fc","article-title":"Prospective evaluation of functional outcome after laparoscopic sigmoid colectomy","volume":"249","author":"Forgione","year":"2009","journal-title":"Ann Surg"},{"key":"2025120519135908000_10.3.e034385.12","doi-asserted-by":"crossref","first-page":"O212","DOI":"10.1111\/codi.12533","article-title":"Inter-Observer reliability of computed tomographic classifications of diverticulitis","volume":"16","author":"Unl\u00fc","year":"2014","journal-title":"Colorectal Dis"},{"key":"2025120519135908000_10.3.e034385.13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00384-011-1314-5","article-title":"Review of current classifications for diverticular disease and a translation into clinical practice","volume":"27","author":"Klarenbeek","year":"2012","journal-title":"Int J Colorectal Dis"},{"key":"2025120519135908000_10.3.e034385.14","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818e416a"},{"key":"2025120519135908000_10.3.e034385.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9705-7"},{"key":"2025120519135908000_10.3.e034385.16","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1111\/j.1463-1318.2012.03026.x","article-title":"Sigmoid diverticulitis in 2011: many questions; few answers","volume":"14","author":"Ambrosetti","year":"2012","journal-title":"Colorectal Disease"},{"key":"2025120519135908000_10.3.e034385.17","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9234-3"},{"key":"2025120519135908000_10.3.e034385.18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/DCR.0b013e31823907a9","article-title":"Sigmoidectomy syndrome? Patients\u02bc perspectives on the functional outcomes following surgery for diverticulitis","volume":"55","author":"Levack","year":"2012","journal-title":"Dis Colon Rectum"},{"key":"2025120519135908000_10.3.e034385.19","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00115-N"},{"key":"2025120519135908000_10.3.e034385.20","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"2025120519135908000_10.3.e034385.21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"2025120519135908000_10.3.e034385.22","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0942-z"},{"key":"2025120519135908000_10.3.e034385.23","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1097\/SLA.0b013e31824f1c21","article-title":"Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer","volume":"255","author":"Emmertsen","year":"2012","journal-title":"Ann Surg"},{"key":"2025120519135908000_10.3.e034385.24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451721"},{"key":"2025120519135908000_10.3.e034385.25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/nau.22496","article-title":"Validation of the urogenital distress inventory (UDI-6) and incontinence impact questionnaire (IIQ-7) in a Dutch population","volume":"34","author":"Utomo","year":"2015","journal-title":"Neurourol Urodyn"},{"key":"2025120519135908000_10.3.e034385.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)00099-0"},{"key":"2025120519135908000_10.3.e034385.27","doi-asserted-by":"publisher","DOI":"10.1080\/009262300278597"},{"key":"2025120519135908000_10.3.e034385.28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jval.2015.05.009","article-title":"The iMTA Productivity Cost questionnaire: a standardized instrument for measuring and Valuing health-related productivity losses","volume":"18","author":"Bouwmans","year":"2015","journal-title":"Value Health"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2019-034385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:14:09Z","timestamp":1764990849000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2019-034385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,24]]},"published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1136\/bmjopen-2019-034385"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2019-034385","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}