{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T17:48:08Z","timestamp":1765734488561,"version":"3.48.0"},"reference-count":20,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"CHD Vendee"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,7,20]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"\n Introduction<\/jats:title>\n Degenerative acromioclavicular joint pain accounts for about 4% of shoulder pain. Various medical and non-medical treatment strategies are available for acromioclavicular joint disease but it is difficult to conduct a comparative evaluation of these treatments. The few studies dealing with the medical management of the disease have conducted no comparative assessment of drug therapies, physiotherapy, joint manipulation and corticosteroid injections. The primary goal of this study is to determine whether manual therapy is not inferior to ultrasound-guided injection of a corticosteroid preparation to decrease acromiocalvicular joint pain at 3 months.<\/jats:p>\n <\/jats:sec>\n \n Methods and analysis<\/jats:title>\n The acromioclavicular arthropathy managed by manual therapy is a monocentric, comparative, randomised, controlled, non-inferiority study conducted in the Rheumatology Department of Vend\u00e9e Departmental Hospital, involving two parallel groups receiving either corticosteroid injections or manual therapy. The inclusion criteria are patients who suffer from pain in the shoulder or the proximal part of the arm, with pain located on palpation of the acromioclavicular joint associated with a positive cross-arm test and a positive O\u2019Brien test. Randomisation will be at a 1:1 ratio. The injection group will receive a single ultrasound-guided injection of 1 mL of Diprost\u00e8ne and the manual therapy group will receive between one and three sessions at intervals of one per week. The primary outcome will be to compare the Visual Analogue Scale for pain-activity-related score at 3\u2009months for both groups.<\/jats:p>\n <\/jats:sec>\n \n Ethics and dissemination<\/jats:title>\n The study project has been approved by the appropriate ethics committee (Committee for the Protection of Patients Ouest II in Angers, 30 April 2019, with the registration number of 2019\/22). In agreement with current French regulations, signed informed written consent will be obtained from each patient. Results of the main trial and of the secondary endpoints will be submitted for publication in a peer-reviewed journal.<\/jats:p>\n <\/jats:sec>\n \n Trial registration number<\/jats:title>\n \n NCT03951480<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-034439","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T08:48:08Z","timestamp":1607590088000},"page":"e034439","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Management of acromioclavicular joint disease by manual therapy versus corticosteroid injections: the protocol of a non-inferiority study"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct03951480","registry":"10.18810\/clinical-trials-gov","type":"preResults"}],"author":[{"given":"Alexia","family":"Michaut","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Departmental Hospital Center, La Roche sur Yon, Vend\u00e9e, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Planche","sequence":"additional","affiliation":[{"name":"Departmental of Rheumatology, Vend\u00e9e Departmental Hospital Center, La Roche sur Yon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Auzanneau","sequence":"additional","affiliation":[{"name":"Departmental of Rheumatology, Vend\u00e9e Departmental Hospital Center, La Roche sur Yon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-3687","authenticated-orcid":false,"given":"Gr\u00e9goire","family":"Cormier","sequence":"additional","affiliation":[{"name":"Departmental of Rheumatology, Vend\u00e9e Departmental Hospital Center, La Roche sur Yon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"2025121409435234000_10.12.e034439.1","unstructured":"Chan A-W , Tetzlaff JM , G\u00f8tzsche PC , et al . 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