{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:22:38Z","timestamp":1765603358024,"version":"3.48.0"},"reference-count":41,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["RP-PG-0614-20009"],"award-info":[{"award-number":["RP-PG-0614-20009"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,2,27]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Partner notification (PN) is a process aiming to identify, test and treat the sex partners of people (index patients) with sexually transmitted infections (STIs). Accelerated partner therapy (APT) is a PN method whereby healthcare professionals assess sex partners, by telephone consultation, before giving the index patient antibiotics and STI self-sampling kits to deliver to their sex partner(s). The Limiting Undetected Sexually Transmitted infections to RedUce Morbidity programme aims to determine the effectiveness of APT in heterosexual women and men with chlamydia and determine whether APT could affect\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                      transmission at population level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This protocol describes a cross-over cluster randomised controlled trial of APT, offered as an additional PN method, compared with standard PN. The trial is accompanied by an economic evaluation, transmission dynamic modelling and a qualitative process evaluation involving patients, partners and healthcare professionals. Clusters are 17 sexual health clinics in areas of England and Scotland with contrasting patient demographics. We will recruit 5440 heterosexual women and men with chlamydia, aged \u226516 years.<\/jats:p>\n                    <jats:p>\n                      The primary outcome is the proportion of index patients testing positive for\n                      <jats:italic>C. trachomatis<\/jats:italic>\n                      12-16 weeks after the PN consultation. Secondary outcomes include: proportion of sex partners treated; cost effectiveness; model-predicted chlamydia prevalence; experiences of APT.\n                    <\/jats:p>\n                    <jats:p>The primary outcome analysis will be by intention-to-treat, fitting random effects logistic regression models that account for clustering of index patients within clinics and trial periods. The transmission dynamic model will be used to predict change in chlamydia prevalence following APT. The economic evaluation will use mathematical modelling outputs, taking a health service perspective. Qualitative data will be analysed using interpretative phenomenological analysis and framework analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This protocol received ethical approval from London\u2014Chelsea Research Ethics Committee (18\/LO\/0773). Findings will be published with open access licences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"ISRCTN15996256\">ISRCTN15996256<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-034806","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T06:05:20Z","timestamp":1585548320000},"page":"e034806","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Accelerated partner therapy (APT) partner notification for people with\n                    <i>Chlamydia trachomatis<\/i>\n                    : protocol for the Limiting Undetected Sexually Transmitted infections to RedUce Morbidity (LUSTRUM) APT cross-over cluster randomised controlled trial"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-5630","authenticated-orcid":false,"given":"Claudia S","family":"Estcourt","sequence":"first","affiliation":[{"name":"School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison R","family":"Howarth","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Copas","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-8986","authenticated-orcid":false,"given":"Nicola","family":"Low","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-6036","authenticated-orcid":false,"given":"Fiona","family":"Mapp","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvina","family":"Woode Owusu","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Flowers","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Roberts","sequence":"additional","affiliation":[{"name":"Health Economics Unit, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine H","family":"Mercer","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Wayal","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"},{"name":"Development Media International CIC, London, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merle","family":"Symonds","sequence":"additional","affiliation":[{"name":"Western Sussex Hospitals NHS Foundation Trust, Worthing, West Sussex, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rak","family":"Nandwani","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow and Clyde, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Saunders","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"},{"name":"Public Health England, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M","family":"Johnson","sequence":"additional","affiliation":[{"name":"Institute for Global Health, UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pothoulaki","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Althaus","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Pickering","sequence":"additional","affiliation":[{"name":"Health Economics Unit, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamsin","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Institute for 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