{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:07:20Z","timestamp":1790870840869,"version":"4.1.0"},"reference-count":11,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874484"],"award-info":[{"award-number":["81874484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,7,16]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Early monitoring of plasma human chorionic gonadotropin (\u03b2-hCG) level is vital in predicting pregnancy outcome. This study investigated the predictive value of serum \u03b2-hCG level on the seventh day after frozen\u2013thawed embryo transfer (FET) for ongoing pregnancy (OP) and adverse pregnancy (AP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>The Reproductive and Genetic Center of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>1061 pregnant women who underwent FET between January 2014 and January 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Pregnancy outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum \u03b2-hCG levels on the seventh day after FET were higher in the single OP group compared with the biochemical pregnancy group (p&lt;0.001). Besides, the serum \u03b2-hCG cut-off level at 4.34 mIU\/mL on the seventh day showed high predictive value (area under the curve (AUC)=0.852). Serum \u03b2-hCG levels on the seventh day after FET were higher in the twin OP group compared with the single OP group (p&lt;0.001). Also, the serum \u03b2-hCG cut-off level at 17.95 mIU\/mL on the seventh day showed high predictive value (AUC=0.903). Serum \u03b2-hCG levels on the seventh day after FET were lower in the ectopic pregnancy group compared with the single OP group (p&lt;0.001) whereas, serum \u03b2-hCG cut-off level at 4.53 mIU\/mL on the seventh day exhibited a high predictive value (AUC=0.860). Further, the serum \u03b2-hCG levels on the seventh day after FET were lower in the single early spontaneous abortion group compared with the single OP group (p&lt;0.001) while the serum \u03b2-hCG cut-off level at 5.34 mIU\/mL on the seventh day exhibited high predictive value (AUC=0.738).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum \u03b2-hCG on the seventh day after FET has good clinical significance for the prediction of OP and AP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-035332","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T13:35:33Z","timestamp":1602336933000},"page":"e035332","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Association between 7-day serum \u03b2-hCG levels after frozen\u2013thawed embryo transfer and pregnancy outcomes: a single-centre retrospective study from China"],"prefix":"10.1136","volume":"10","author":[{"given":"Lihua","family":"Yuan","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-1213","authenticated-orcid":false,"given":"Zhengao","family":"Sun","sequence":"additional","affiliation":[{"name":"Integrative Medicine Research Centre of Reproduction and Heredity, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"2025121600003447000_10.10.e035332.1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.fertnstert.2011.05.071","article-title":"Serum beta human chorionic gonadotropin levels can inform outcome counseling after in vitro fertilization","volume":"96","author":"Lawler","year":"2011","journal-title":"Fertil Steril"},{"key":"2025121600003447000_10.10.e035332.2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s10815-016-0744-y","article-title":"Serum hCG-\u03b2 levels of postovulatory day 12 and 14 with the sequential application of hCG-\u03b2 fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle","volume":"33","author":"Sung","year":"2016","journal-title":"J Assist Reprod 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following day 3 embryo transfer might predict pregnancy outcome in IVF","volume":"33","author":"Wang","year":"2017","journal-title":"Gynecol Endocrinol"},{"key":"2025121600003447000_10.10.e035332.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03278-8"},{"key":"2025121600003447000_10.10.e035332.10","first-page":"1539","article-title":"Analysis of embryo implantation and clinical pregnancy outcome in women of different ages","volume":"24","author":"Song","year":"2008","journal-title":"J Pract Med"},{"key":"2025121600003447000_10.10.e035332.11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den017"}],"container-title":["BMJ 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