{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:30:38Z","timestamp":1777401038179,"version":"3.51.4"},"reference-count":49,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["project number 848050007 and project number 848050"],"award-info":[{"award-number":["project number 848050007 and project number 848050"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,5,21]]},"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Anticoagulation therapy is pivotal in the management of stroke prevention in atrial fibrillation (AF). Prospective registries, containing longitudinal data are lacking with detailed information on anticoagulant therapy, treatment adherence and AF-related adverse events in practice-based patient cohorts, in particular for non-vitamin K oral anticoagulants (NOAC). With the creation of DUTCH-AF, a nationwide longitudinal AF registry, we aim to provide clinical data and answer questions on the (anticoagulant) management over time and of the clinical course of patients with newly diagnosed AF in routine clinical care. Within DUTCH-AF, our current aim is to assess the effect of non-adherence and non-persistence of anticoagulation therapy on clinical adverse events (eg, bleeding and stroke), to determine predictors for such inadequate anticoagulant treatment, and to validate and refine bleeding prediction models. With DUTCH-AF, we provide the basis for a continuing nationwide AF registry, which will facilitate subsequent research, including future registry-based clinical trials.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The DUTCH-AF registry is a nationwide, prospective registry of patients with newly diagnosed \u2018non-valvular\u2019 AF. Patients will be enrolled from primary, secondary and tertiary care practices across the Netherlands. A target of 6000 patients for this initial cohort will be followed for at least 2 years. Data on thromboembolic and bleeding events, changes in antithrombotic therapy and hospital admissions will be registered. Pharmacy-dispensing data will be obtained to calculate parameters of adherence and persistence to anticoagulant treatment, which will be linked to AF-related outcomes such as ischaemic stroke and major bleeding. In a subset of patients, anticoagulation adherence and beliefs about drugs will be assessed by questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>This study protocol was approved as exempt for formal review according to Dutch law by the Medical Ethics Committee of the Leiden University Medical Centre, Leiden, the Netherlands. Results will be disseminated by publications in peer-reviewed journals and presentations at scientific congresses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>Trial NL7467, NTR7706 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.trialregister.nl\/trial\/7464\">https:\/\/www.trialregister.nl\/trial\/7464<\/jats:ext-link>).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2019-036220","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T03:21:24Z","timestamp":1598325684000},"page":"e036220","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Design and rationale of DUTCH-AF: a prospective nationwide registry programme and observational study on long-term oral antithrombotic treatment in patients with atrial fibrillation"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-3094","authenticated-orcid":false,"given":"Gordon","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap","family":"Seelig","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rijnstate, Arnhem, The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-9253","authenticated-orcid":false,"given":"Emmy M","family":"Trinks-Roerdink","sequence":"additional","affiliation":[{"name":"Department of General Practice, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk P","family":"van Alem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haaglanden Medical Centre, The Hague, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Alings","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amphia Hospital, Breda, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"van den Bemt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands"},{"name":"Department of Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas VA","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne C","family":"Cannegieter","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"ten Cate","sequence":"additional","affiliation":[{"name":"Thrombosis Expert Centre, Maastricht University Medical Centre, Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles JHJ","family":"Kirchhof","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Alrijne Hospital, Leiderdorp, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-5337","authenticated-orcid":false,"given":"Harry JGM","family":"Crijns","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewoud J","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, Radboud University Medical Centre, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arif","family":"Elvan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Isala Heart Centre, Isala Hospitals, Zwolle, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle C","family":"van Gelder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Groningen, Groningen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris R","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Centre, Amsterdam University Medical Centre\/University of Amsterdam, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank R","family":"den Hartog","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gelderse Vallei Hospital, Ede, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas SSG","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Centre, OLVG, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Elkerliek Hospital, Helmond, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederikus A","family":"Klok","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Lenderink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zuyderland Medical Centre, Heerlen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin G","family":"Luermans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University Medical Centre+, Maastricht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan G","family":"Meeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, VieCuri Medical Centre Noord-Limburg, Venlo, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Pisters","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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