{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:27:31Z","timestamp":1765074451276,"version":"3.46.0"},"reference-count":17,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"unspecified","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,10,9]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore the time trend and geographical distribution of childhood leukaemia incidence over the territory of the Italian region of Sardinia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>All hospitals departments, diagnostic centres and social security agencies in Sardinia were regularly screened in 1974\u20132003 to identify, register and review the diagnoses of incident cases of haematological malignancies (HM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The whole child population aged 0\u201314 resident in Sardinia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Incidence and time trend of childhood HM and childhood acute lymphoblastic leukaemia (ALL) over the study period, and use of Bayesian methods to plot the probability of areas with excess incidence on the regional map.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 675 HM cases, including 378 ALL cases, occurred among children aged 0\u201314 years resident in Sardinia in 1974\u20132003, with an incidence rate of 6.97\u00d710\n                      <jats:sup>-5<\/jats:sup>\n                      (95%\u2009CI 6.47 to 7.51) and 3.85\u00d710\n                      <jats:sup>-5<\/jats:sup>\n                      (95%\u2009CI 3.48 to 4.26), respectively. Incidence of HM and ALL showed an upward trend along the study period especially among females. Three communes out of the 356 existing in 1974, namely Ittiri, Villa San Pietro and Carbonia, stand out as areas with excess incidence of HM and ALL in particular and another, Carloforte, for ALL only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results might serve as convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants in the areas at risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-037163","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T03:20:42Z","timestamp":1604460042000},"page":"e037163","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Haemolymphatic cancer among children in Sardinia, Italy: 1974\u20132003 incidence"],"prefix":"10.1136","volume":"10","author":[{"given":"Giorgio","family":"Broccia","sequence":"first","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplants, Oncologico A. Businco Hospital, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Carter","sequence":"additional","affiliation":[{"name":"School of Energy, Construction, Coventry University, Coventry, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansu","family":"Ozsin-Ozler","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Paediatric Dentistry, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Meloni","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-5652","authenticated-orcid":false,"given":"Ilaria","family":"Pilia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannina","family":"Satta","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Murgia","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncohaematology, Microcitemico Hospital, Cagliari, Sardegna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"2025120618054304000_10.11.e037163.1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007574016008"},{"key":"2025120618054304000_10.11.e037163.2","first-page":"551","article-title":"Incidenza della leucemia acuta infantile nella provincia di Sassari (anno 1978): elevazione casuale dell\u2019incidenza o \u201ccluster\u201d?","volume":"84","author":"Cornaglia Ferraris","year":"1981","journal-title":"Rass Med Sarda"},{"key":"2025120618054304000_10.11.e037163.3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1179\/oeh.1995.1.3.232","article-title":"Childhood acute lymphoblastic leukemia: a cluster in southwestern Sardinia (Italy)","volume":"1","author":"Cocco","year":"1995","journal-title":"Int J Occup Environ Health"},{"key":"2025120618054304000_10.11.e037163.4","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1996.9936022"},{"key":"2025120618054304000_10.11.e037163.5","first-page":"1558","article-title":"Age distribution of childhood acute lymphoblastic leukemia cases suggests etiological clues","volume":"10","author":"Cocco","year":"1996","journal-title":"Leukemia"},{"key":"2025120618054304000_10.11.e037163.6","article-title":"The history and geography of human gene (abridged paperback edition)","volume":"2","author":"Cavalli-Sforza","year":"1996","journal-title":"J R Anthropol Inst"},{"key":"2025120618054304000_10.11.e037163.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237947"},{"key":"2025120618054304000_10.11.e037163.8","doi-asserted-by":"crossref","DOI":"10.1177\/1352458517732841","article-title":"Investigating multiple sclerosis genetic susceptibility on the founder population of east-central Sardinia via association and linkage analysis of immune-related loci","volume":"24","author":"Fazia","year":"2018","journal-title":"Mult Scler"},{"key":"2025120618054304000_10.11.e037163.9","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00277-013-2002-z","article-title":"A 30-year epidemiologic survey (1974-2003) of haematological malignancies on the island of Sardinia: temporal changes in incidence and a geographic comparison of incidence rates","volume":"93","author":"Broccia","year":"2014","journal-title":"Ann Hematol"},{"key":"2025120618054304000_10.11.e037163.10","first-page":"41","article-title":"[Lessons learned from the \u201cQuirra syndrome\u201d epidemiology? 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