{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:14:54Z","timestamp":1792808094836,"version":"4.5.0"},"reference-count":47,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"unspecified","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Research Council of the KU Leuven","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,8,11]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the performance of the \u2018van Loendersloot\u2019 prognostic model for our clinic\u2019s in vitro fertilisation (IVF) in its original version, the refitted version and in an adapted version replacing previous by current cycle IVF laboratory variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study in our academic tertiary fertility clinic analysed 1281 IVF cycles of 591 couples, who completed at least one 2nd\u20136th IVF cycle with own fresh gametes after a previous IVF cycle with the same partner in our clinic between 2010 and 2018. The outcome of interest was the chance on a live birth after one complete IVF cycle (including all fresh and frozen embryo transfers from the same episode of ovarian stimulation). Model performance was expressed in terms of discrimination (c-statistics) and calibration (calibration model, comparison of prognosis to observed ratios of five disjoint groups formed by the quintiles of the IVF prognoses and a calibration plot).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 344 live births were obtained (26.9%). External validation of the original van Loendersloot model showed a poor c-statistic of 0.64 (95% CI: 0.61 to 0.68) and an underestimation of IVF success. The refitted and the adapted models showed c-statistics of respectively 0.68 (95% CI: 0.65 to 0.71) and 0.74 (95% CI: 0.70 to 0.77). Similar c-statistics were found with cross-validation. Both models showed a good calibration model; refitted model: intercept=0.00 (95% CI: \u22120.23 to 0.23) and slope=1.00 (95% CI: 0.79 to 1.21); adapted model: intercept=0.00 (95% CI: \u22120.18 to 0.18) and slope=1.00 (95% CI: 0.83 to 1.17). Prognoses and observed success rates of the disjoint groups matched well for the refitted model and even better for the adapted model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>External validation of the original van Loendersloot model indicated that model updating was recommended. The good performance of the refitted and adapted models allows informing couples about their IVF prognosis prior to an IVF cycle and at the time of embryo transfer. Whether this has an impact on couple\u2019s expected success rates, distress and IVF discontinuation can now be studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-037289","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T02:46:10Z","timestamp":1602211570000},"page":"e037289","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Predicting the chance on live birth per cycle at each step of the IVF journey: external validation and update of the van Loendersloot multivariable prognostic model"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-9438","authenticated-orcid":false,"given":"Johanna","family":"Devroe","sequence":"first","affiliation":[{"name":"Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium"},{"name":"Development and Regeneration, Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Peeraer","sequence":"additional","affiliation":[{"name":"Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium"},{"name":"Development and Regeneration, Laboratory of Endometrium, Endometriosis & Reproductive Medicine, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Verbeke","sequence":"additional","affiliation":[{"name":"Public Health and Primary Care, Leuven Biostatistics and statistical Bioinformatics Centre, Leuven, Belgium"},{"name":"Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Spiessens","sequence":"additional","affiliation":[{"name":"Leuven University Fertility Centre, University Hospital Leuven, Leuven, 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