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This systematic review intends to consolidate the evidence on the economic evaluation of four clinical best practices (CBPs) related to NI prevention and control interventions: hand hygiene, hygiene and sanitation, admission screening and basic and additional precautions. It will measure the return on investment of these CBPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      Electronic searches will be conducted on MEDLINE, CINAHL, EMBASE, Cochrane, Web of Science and JSTOR. OpenGrey will also be consulted for articles from 2000 to 2018, published in English or French. The population includes studies undertaken in medical or surgical units of hospitals of the Organisation for Economic Co-operation and Development countries. Studies will report the prevention and control of\n                      <jats:italic>Clostridium difficile-<\/jats:italic>\n                      associated diarrhoea, methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      , vancomycin-resistant enterococci and carbapenem-resistant Gram-negative bacilli. Interventions evaluating any of the four CBPs will be included. The design of articles will fall within randomised clinical trials, quasi-experimental, case-control, cohort, longitudinal and cross-sectional studies. Outcomes will include incremental cost-effectiveness ratio, incremental cost per quality-adjusted life-year, incremental cost per disability-adjusted life year and the incremental cost-benefit ratio, net costs and net cost savings. Two authors will independently screen studies, extract data and assess risk of bias using the Scottish Intercollegiate Guidelines, the Drummond Economic Evaluation criteria and the Cochrane criteria for Systematic Reviews of Interventions. Consolidated Health Economic Evaluation Reporting Standards will be used for data extraction. All values will be adjusted to Canadian dollars ($C) indexed to 2019 using the discount rates (3%, 5% and 8%) for sensitivity analyses. This review will demonstrate the effectiveness of the CBPs in prevention and control of NIs. Decision-makers will thus have evidence to facilitate sound decision-making according to the financial gains generated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The results of this systematic review will be published in a peer-reviewed journal and presented at a relevant scientific conference. Ethical approval is not required because the data we will use do not include individual patient data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-037765","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T02:33:13Z","timestamp":1594780393000},"page":"e037765","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Protocol for a systematic review of economic analyses of nosocomial infection prevention and control interventions in OECD hospitals"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-0478","authenticated-orcid":false,"given":"Eric Nguemeleu","family":"Tchouaket","sequence":"first","affiliation":[{"name":"Sciences Infirmi\u00e8res, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idrissa","family":"Beogo","sequence":"additional","affiliation":[{"name":"School of Nursing and Health, Universit\u00e9 de Saint-Boniface, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drissa","family":"Sia","sequence":"additional","affiliation":[{"name":"Nursing, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2137-6560","authenticated-orcid":false,"given":"Kelley","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Nursing, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"S\u00e9guin","sequence":"additional","affiliation":[{"name":"Universite du Quebec en Outaouais, Gatineau, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelie","family":"Baillot","sequence":"additional","affiliation":[{"name":"Nursing, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Nadar","sequence":"additional","affiliation":[{"name":"Nursing, Universit\u00e9 du Qu\u00e9bec en Outaouais, Gatineau, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Parisien","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Quebec, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Boivin","sequence":"additional","affiliation":[{"name":"CISSS des Laurentides, Saint-Jerome, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"2025120518001180000_10.7.e037765.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"2025120518001180000_10.7.e037765.2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ajic.2015.09.005","article-title":"Extra length of stay and costs because of health care-associated infections at a German university hospital","volume":"44","author":"Arefian","year":"2016","journal-title":"Am J Infect Control"},{"key":"2025120518001180000_10.7.e037765.3","doi-asserted-by":"crossref","DOI":"10.1186\/s12882-017-0784-2","article-title":"Health care costs associated with Hospital acquired complications in patients with chronic kidney disease","volume":"18","author":"Bohlouli","year":"2017","journal-title":"BMC Nephrol"},{"key":"2025120518001180000_10.7.e037765.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002150"},{"key":"2025120518001180000_10.7.e037765.5","unstructured":"Laberge A , Carignan A , Galarneau LA , et al . 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