{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:51:05Z","timestamp":1782489065960,"version":"3.54.5"},"reference-count":14,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"unspecified","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,7,21]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Observational population-based research is a very suitable non-invasive method for studies in the vulnerable populations of pregnant women and children. Therefore, the PHARMO Perinatal Research Network (PPRN) was set up as a resource for life course perinatal and paediatric research by linking population-based data from existing registrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>From 1999 to 2017, the PPRN captures approximately 542\u2009900 pregnancies of 387\u2009100 mothers (\u2018Pregnancy Cohort\u2019). Additionally, mother\u2013child linkage is currently available for a quarter of these pregnancies (\u2018Child Cohort\u2019). The PPRN contains preconceptional information on maternal healthcare, as well as detailed pregnancy and neonatal data, extending into long-term follow-up and outcomes after birth for both mother and child up to nearly 20 years. It includes linked data from different primary and secondary healthcare settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>Through record linkage of the Netherlands Perinatal Registry and the PHARMO Database Network, we have established a large population-based research network including data on demographics, medication use, medical conditions and details concerning labour, birth and neonatal outcomes. Here, we provide an overview of record types available from the PPRN, available database follow-up and pregnancy characteristics of the PPRN cohorts. The PPRN has been used for a number of different pharmacoepidemiological studies, for example, to confirm that preterm-born infants were more likely than full-term infants to be hospitalised or use medication. Similar long-term comparisons showed that children born following spontaneous preterm labour were at increased risk of neurodevelopmental and respiratory conditions. Most recently, the PPRN provided important evidence on the trends in use of potentially harmful medication during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The PPRN provides a unique and rich data set facilitating large-scale observational pharmacoepidemiological perinatal research. The patient-level linkage of many different healthcare data sources allows for long-term follow-up of mother and child, with ongoing annual updates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-037837","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:36:16Z","timestamp":1601055376000},"page":"e037837","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Cohort profile: the PHARMO Perinatal Research Network (PPRN) in the Netherlands: a population-based mother\u2013child linked cohort"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-3335","authenticated-orcid":false,"given":"E.","family":"Houben","sequence":"first","affiliation":[{"name":"PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands"},{"name":"Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Broeders","sequence":"additional","affiliation":[{"name":"Perined, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.P.","family":"Steegers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.C.","family":"Herings","sequence":"additional","affiliation":[{"name":"PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands"},{"name":"Department of Epidemiology and Biostatistics, Amsterdam UMC, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"2026062608043296000_10.9.e037837.1","unstructured":"Grote Lijnen 1999-2012 . Stichting perinatale registratie Nederland, 2013."},{"key":"2026062608043296000_10.9.e037837.2","doi-asserted-by":"crossref","first-page":"883.e1","DOI":"10.1016\/j.jclinepi.2006.11.021","article-title":"Probabilistic record linkage is a valid and transparent tool to combine databases without a patient identification number","volume":"60","author":"M\u00e9ray","year":"2007","journal-title":"J Clin Epidemiol"},{"key":"2026062608043296000_10.9.e037837.3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2147\/CLEP.S247575","article-title":"Existing data sources for clinical epidemiology: the PHARMO database network","volume":"12","author":"Kuiper","year":"2020","journal-title":"Clin Epidemiol"},{"key":"2026062608043296000_10.9.e037837.4","doi-asserted-by":"crossref","unstructured":"Herings R , Pedersen L . Pharmacy-based medical record linkage systems. In: Strom B , Kimmel S , Hennessy S , eds. Pharmacoepidemiology. 5th edn. John Wiley & Sons, Ltd, 2012: 270\u201386.","DOI":"10.1002\/9781119959946.ch18"},{"key":"2026062608043296000_10.9.e037837.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.09.010"},{"key":"2026062608043296000_10.9.e037837.6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpeds.2012.12.014","article-title":"First year of life medication use and hospital admission rates: premature compared with term infants","volume":"163","author":"Houweling","year":"2013","journal-title":"J Pediatr"},{"key":"2026062608043296000_10.9.e037837.7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/jpc.14225","article-title":"Increased risk of morbidities and health-care utilisation in children born following preterm labour compared with full-term labour: a population-based study","volume":"55","author":"Houben","year":"2019","journal-title":"J Paediatr Child Health"},{"key":"2026062608043296000_10.9.e037837.8","article-title":"Dutch trends in the use of potentially harmful medication during pregnancy","volume":"157","author":"Houben","year":"2020","journal-title":"Br J Clin Pharmacol"},{"key":"2026062608043296000_10.9.e037837.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2012.10.003"},{"key":"2026062608043296000_10.9.e037837.10","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu709"},{"key":"2026062608043296000_10.9.e037837.11","unstructured":"Perined . Perinatale Zorg in Nederland 2016. Perined: Utrecht, 2018."},{"key":"2026062608043296000_10.9.e037837.12","unstructured":"Dutch hospital data Foundation. Available: https:\/\/www.dhd.nl\/Paginas\/home.aspx"},{"key":"2026062608043296000_10.9.e037837.13","unstructured":"Palga Foundation . The nationwide network and registry of histo- and cytopathology in the Netherlands, 2018. Available: http:\/\/www.palga.nl\/ [Accessed 17 Apr 2018]."},{"key":"2026062608043296000_10.9.e037837.14","unstructured":"Netherlands Comprehensive Cancer Organisation . Netherlands cancer registry, 2018. Available: https:\/\/www.iknl.nl\/ [Accessed 17 Apr 2018]."}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-037837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:20:20Z","timestamp":1782487220000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-037837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":14,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,25]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/bmjopen-2020-037837"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-037837","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}