{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:49:29Z","timestamp":1782488969416,"version":"3.54.5"},"reference-count":25,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"unspecified","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,8,24]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to clarify the prevalence, indications, analgesic comedications and complications of prescription opioid use in patients presenting to a large emergency department (ED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Large, interdisciplinary ED of a public hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>All patients aged \u226518 years presenting between 1 January 2017, and 31 December 2018, with documentation on medication were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Prevalence rates for prescription opioid use and its indication. Prevalence of analgesic comedications in prescription opioid users. Hospitalisation rate, 72\u2009hours ED reconsultation rate, 30-day rehospitalisation rate, in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 26\u2009224 consultations were included in the analysis; 1906 (7.3%) patients had prescriptions for opioids on admission to the ED. The main indications for opioid prescriptions were musculoskeletal disease in 1145 (60.1%) patients, followed by neoplastic disease in 374 (19.6%) patients. One hundred fifty-four (8.2%) consultations were directly related to opioid intake, and 50.1% of patients on opioids also used other classes of analgesics. Patients on prescription opioids were older (76 vs 62 years, p&lt;0.0001) and female individuals were over-represented (58 vs 48.9%, p&lt;0.0001). Hospitalisation rate (78.3 vs 49%, p&lt;0.0001), 72\u2009hours ED reconsultation rate (0.8 vs 0.3%, p=0.004), 30-day rehospitalisation rate (6.2 vs 1.5%, p&lt;0.0001) and in-hospital mortality (6.3 vs 1.6%, p&lt;0.0001) were significantly higher in patients with opioid therapy than other patients. In 25 cases (1.3%), admission to the ED was due to opioid intoxication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daily prescription opioid use is common in patients presenting to the ED. The use of prescription opioids is associated with adverse outcomes, whereas intoxication is a minor issue in the studied population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-038079","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T17:36:25Z","timestamp":1601055385000},"page":"e038079","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Patterns of prescription opioid use in Swiss emergency department patients and its association with outcome: a retrospective analysis"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-5017","authenticated-orcid":false,"given":"Bertram K","family":"Woitok","sequence":"first","affiliation":[{"name":"Department of Internal and Emergency Medicine, B\u00fcrgerspital Solothurn, Solothurn, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"B\u00fcttiker","sequence":"additional","affiliation":[{"name":"Department of Internal and Emergency Medicine, B\u00fcrgerspital Solothurn, Solothurn, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Ravioli","sequence":"additional","affiliation":[{"name":"Department of Internal and Emergency Medicine, B\u00fcrgerspital Solothurn, Solothurn, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg-Christian","family":"Funk","sequence":"additional","affiliation":[{"name":"Karl-Landsteiner-Institute for Lung Research and Pulmonary Oncology, Wilhelminenspital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristomenis K","family":"Exadaktylos","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Inselspital Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Internal and Emergency Medicine, B\u00fcrgerspital Solothurn, Solothurn, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"2026062608030359000_10.9.e038079.1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s40122-017-0090-5","article-title":"A review of current and emerging approaches to pain management in the emergency department","volume":"6","author":"Todd","year":"2017","journal-title":"Pain Ther"},{"key":"2026062608030359000_10.9.e038079.2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.annemergmed.2015.11.033","article-title":"Emergency department prescription opioids as an initial exposure preceding addiction","volume":"68","author":"Butler","year":"2016","journal-title":"Ann Emerg Med"},{"key":"2026062608030359000_10.9.e038079.3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1017\/cem.2017.370","article-title":"Creating opioid dependence in the emergency department","volume":"20","author":"Upadhye","year":"2018","journal-title":"CJEM"},{"key":"2026062608030359000_10.9.e038079.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.11.015"},{"key":"2026062608030359000_10.9.e038079.5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.drugalcdep.2015.12.007","article-title":"A comparison of an opioid abuse screening tool and prescription drug monitoring data in the emergency department","volume":"159","author":"Weiner","year":"2016","journal-title":"Drug Alcohol Depend"},{"key":"2026062608030359000_10.9.e038079.6","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.ajem.2018.03.055","article-title":"Rate of patients at elevated risk of opioid overdose visiting the emergency department","volume":"36","author":"Pedigo","year":"2018","journal-title":"Am J Emerg Med"},{"key":"2026062608030359000_10.9.e038079.7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/ejp.1337","article-title":"Trends in the consumption of opioids for the treatment of severe pain in Europe, 1990-2016","volume":"23","author":"Bosetti","year":"2019","journal-title":"Eur J Pain"},{"key":"2026062608030359000_10.9.e038079.8","doi-asserted-by":"crossref","first-page":"e498","DOI":"10.1016\/S2468-2667(19)30128-8","article-title":"Trends in use and misuse of opioids in the Netherlands: a retrospective, multi-source database study","volume":"4","author":"Kalkman","year":"2019","journal-title":"Lancet Public Health"},{"key":"2026062608030359000_10.9.e038079.9","doi-asserted-by":"publisher","DOI":"10.2174\/187447370801150611184218"},{"key":"2026062608030359000_10.9.e038079.10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.24095\/hpcdp.38.6.04","article-title":"At-a-glance - 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Umrechnungsfaktoren zur Opioidrotation, 2019. Available: https:\/\/www.unispital-basel.ch\/fileadmin\/unispitalbaselch\/Bereiche\/Querschnittsfunktionen\/Spital-Pharmazie\/Aequivalenz_Opioide.pdf [Accessed 11 Aug 2016]."}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-038079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:09:08Z","timestamp":1782486548000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-038079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,25]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/bmjopen-2020-038079"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-038079","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}