{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:19:15Z","timestamp":1793398755070,"version":"4.5.0"},"reference-count":35,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"\u201cThe 13th Five-year\u2019\u2019 National Science and Technology Pillar Program by the Ministry of Science and Technology of the People\u2019s Republic of China","award":["2017YFC1703602"],"award-info":[{"award-number":["2017YFC1703602"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,12,21]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Evidence specific for stress-predominant mixed urinary incontinence is still lacking at present, and acupuncture may relieve the symptoms. We plan to conduct this multi-centre, three-armed, randomised controlled trial to investigate the efficacy and safety of electroacupuncture among women with stress-predominant mixed urinary incontinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The trial will be conducted at five hospitals in China. Two hundred thirty-two eligible women will be randomly assigned (2:1:1) to the electroacupuncture, sham electroacupuncture or waiting-list group to receive either 24-session acupuncture\/sham acupuncture treatment over 8 weeks and 24-week follow-up or 20-week watchful waiting. The primary outcome is the proportion of participants with at least 50% reduction in mean 24-hour stress incontinence episode frequencies from baseline to week 8. The outcome will be analysed with the intention to treatpopulation (defined as participants randomised) with a two-sided p value of less than 0.05 considered significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The protocol has been approved by Guang\u2019anmen Hospital Institutional Review Board (2019-241-KY). Detailed information of the trial will be informed to the participants, and written informed consent will be obtained from every participant. Results of the trial are expected to be published in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      ClinicalTrials.gov Registry (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\" xlink:href=\"NCT04299932\">NCT04299932<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-038452","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T12:42:51Z","timestamp":1610023371000},"page":"e038452","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Electroacupuncture for stress-predominant mixed urinary incontinence: a protocol for a three-armed randomised controlled trial"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct04299932","registry":"10.18810\/clinical-trials-gov","type":"preResults"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-3047","authenticated-orcid":false,"given":"Yuanjie","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Acupuncture, Guang\"anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4125-0666","authenticated-orcid":false,"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Guang\"anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Guang\"anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7570-8917","authenticated-orcid":false,"given":"Zhishun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, Guang\"anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2025121222250294000_11.1.e038452.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"2025121222250294000_11.1.e038452.2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31828ca761"},{"key":"2025121222250294000_11.1.e038452.3","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00192-008-0637-4","article-title":"Mixed incontinence is more bothersome than pure incontinence subtypes","volume":"19","author":"Dooley","year":"2008","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"2025121222250294000_11.1.e038452.4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijgo.2009.10.017","article-title":"Epidemiology of mixed urinary incontinence in China","volume":"109","author":"Zhu","year":"2010","journal-title":"Int J Gynaecol Obstet"},{"key":"2025121222250294000_11.1.e038452.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00039-X"},{"key":"2025121222250294000_11.1.e038452.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4299"},{"key":"2025121222250294000_11.1.e038452.7","unstructured":"Burkhard FC , Bosch J , Cruz F . 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