{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:24:02Z","timestamp":1781112242266,"version":"3.54.1"},"reference-count":37,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the National Science and Technology Support Program of the ministry of science and technology of China","award":["2013BAI05B00"],"award-info":[{"award-number":["2013BAI05B00"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673887"],"award-info":[{"award-number":["81673887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,11,12]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Neck pain causes serious social and economic burden. Research on the use of acupuncture for managing cervical spondylosis has increased over time, with the quality of studies showing an improved trend. The present study seeks to use a systematic review approach to understand efficacy and safety of acupuncture for treatment of neck pain caused by cervical spondylosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will search PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, Chinese BioMedical Literature, Wanfang database and VIP databases, from their inception to July 2020, to identify and retrieve all randomised controlled trials, describing the use of acupuncture for treatment of cervical spondylosis. Thereafter, two reviewers will independently select the studies, extract data and assess the risk of bias. Any disagreements, between them, will be resolved through a discussion with a third reviewer. Data synthesis and statistical analyses will be performed using the Revman V.5.3 software. Specifically, data will be synthesised by either fixed-effects (heterogeneity less than 50%) or random-effects models, following a heterogeneity test, with outcome measures focusing on pain intensity, functional disability, psychological improvements and adverse events. In cases where no considerable heterogeneity is detected, a meta-analysis will be conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>No ethical approval will be required for this study, since it does not infringe on anyone\u2019s interests. The findings will be published in a peer-reviewed journal or disseminated through conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42020152379.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-038455","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T18:20:21Z","timestamp":1608661221000},"page":"e038455","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Acupuncture for neck pain caused by cervical spondylosis: a systematic review and meta-analysis protocol"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8410-8630","authenticated-orcid":false,"given":"Zhen","family":"Gao","sequence":"first","affiliation":[{"name":"Acupuncture and Tuina School\/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao-Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate Faculty, Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of acupuncture, Affiliated Hospital of Shanxi University of Traditional Chinese Medicine, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Xi","family":"Ji","sequence":"additional","affiliation":[{"name":"The 3rd Teaching Hospital, Shanxi University of Traditional Chinese Medicine, Jinzhong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"2025121410004173000_10.12.e038455.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.09.008"},{"key":"2025121410004173000_10.12.e038455.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000219875.19688.a6"},{"key":"2025121410004173000_10.12.e038455.3","first-page":"219","article-title":"Comparison of neck length, relative neck length and height with incidence of cervical spondylosis","volume":"36","author":"Ahmed","year":"2020","journal-title":"Pak J Med Sci"},{"key":"2025121410004173000_10.12.e038455.4","first-page":"47","article-title":"The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis","volume":"11","author":"Wang","year":"2016","journal-title":"Clin Interv Aging"},{"key":"2025121410004173000_10.12.e038455.5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3233\/THC-174717","article-title":"The effect of sitting posture on the loads at cervico-thoracic and lumbosacral joints","volume":"26","author":"Kwon","year":"2018","journal-title":"Technol Health Care"},{"key":"2025121410004173000_10.12.e038455.6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jcm.2017.03.004","article-title":"Association between forward head, Rounded shoulders, and increased thoracic kyphosis: a review of the literature","volume":"16","author":"Singla","year":"2017","journal-title":"J Chiropr Med"},{"key":"2025121410004173000_10.12.e038455.7","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-018-2234-0","article-title":"The prevalence and associated factors of symptomatic cervical spondylosis in Chinese adults: a community-based cross-sectional study","volume":"19","author":"Lv","year":"2018","journal-title":"BMC Musculoskelet Disord"},{"key":"2025121410004173000_10.12.e038455.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01714.x"},{"key":"2025121410004173000_10.12.e038455.9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.36076\/ppj.2003\/6\/319","article-title":"Epidural steroids in the management of chronic spinal pain and radiculopathy","volume":"6","author":"Boswell","year":"2003","journal-title":"Pain Physician"},{"key":"2025121410004173000_10.12.e038455.10","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.2147\/JPR.S180018","article-title":"Cervical disc degeneration and neck pain","volume":"11","author":"Peng","year":"2018","journal-title":"J Pain Res"},{"key":"2025121410004173000_10.12.e038455.11","first-page":"335","article-title":"Clinical effectiveness of Interlaminar epidural injections of local anesthetic with or without steroids for managing chronic neck pain: a systematic review and meta-analysis","volume":"23","author":"Mesregah","year":"2020","journal-title":"Pain Physician"},{"key":"2025121410004173000_10.12.e038455.12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.36076\/ppj\/2015.18.39","article-title":"Do cervical epidural injections provide long-term relief in neck and upper extremity pain? A systematic review","volume":"18","author":"Manchikanti","year":"2015","journal-title":"Pain Physician"},{"key":"2025121410004173000_10.12.e038455.13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3221"},{"key":"2025121410004173000_10.12.e038455.14","first-page":"783","article-title":"Pillow preferences of people with neck pain and known spinal degeneration: a pilot randomized controlled trial","volume":"55","author":"Gordon","year":"2019","journal-title":"Eur J Phys Rehabil Med"},{"key":"2025121410004173000_10.12.e038455.15","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2017.0302"},{"key":"2025121410004173000_10.12.e038455.16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5271\/sjweh.3760","article-title":"The impact of workplace Ergonomics and neck-specific exercise versus Ergonomics and health promotion interventions on office worker productivity: a cluster-randomized trial","volume":"45","author":"Pereira","year":"2019","journal-title":"Scand J Work Environ Health"},{"key":"2025121410004173000_10.12.e038455.17","first-page":"Cd007407","article-title":"Psychological therapies for the management of chronic pain (excluding headache) in adults","volume":"11","author":"Williams","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121410004173000_10.12.e038455.18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00421-018-3802-6","article-title":"Effects of combining ergonomic interventions and motor control exercises on muscle activity and kinematics in people with work-related neck-shoulder pain","volume":"118","author":"Tsang","year":"2018","journal-title":"Eur J Appl Physiol"},{"key":"2025121410004173000_10.12.e038455.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2018.05.003"},{"key":"2025121410004173000_10.12.e038455.20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jep.2012.01.052","article-title":"Exploring practice characteristics and research priorities of practitioners of traditional acupuncture in China and the EU-A survey","volume":"140","author":"Robinson","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"2025121410004173000_10.12.e038455.21","doi-asserted-by":"publisher","DOI":"10.1007\/s004820100094"},{"key":"2025121410004173000_10.12.e038455.22","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1130-9"},{"key":"2025121410004173000_10.12.e038455.23","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes136"},{"key":"2025121410004173000_10.12.e038455.24","first-page":"537","article-title":"[High Mobility Group Box 1\/ CD 24 Receptor\/\u03b2-EP Signaling in \"Zusanli\" (ST 36) Region Contributes to Electroacupuncture Analgesia in Rats with Neuropathic Pain]","volume":"43","author":"Gao","year":"2018","journal-title":"Zhen Ci Yan Jiu"},{"key":"2025121410004173000_10.12.e038455.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.12.019"},{"key":"2025121410004173000_10.12.e038455.26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/PHM.0000000000000266","article-title":"Evidence for the use of ischemic compression and dry Needling in the management of trigger points of the upper trapezius in patients with neck pain: a systematic review","volume":"94","author":"Cagnie","year":"2015","journal-title":"Am J Phys Med Rehabil"},{"key":"2025121410004173000_10.12.e038455.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00234-7"},{"key":"2025121410004173000_10.12.e038455.28","first-page":"Cd004870","article-title":"Acupuncture for neck disorders","volume":"5","author":"Trinh","year":"2016","journal-title":"The Cochrane database of systematic reviews"},{"key":"2025121410004173000_10.12.e038455.29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117146","article-title":"Traditional Chinese medicine for neck pain and low back pain: a systematic review and meta-analysis","volume":"10","author":"Yuan","year":"2015","journal-title":"PLoS One"},{"key":"2025121410004173000_10.12.e038455.30","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0135"},{"key":"2025121410004173000_10.12.e038455.31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181360","article-title":"Efficacy of abdominal acupuncture for neck pain: a randomized controlled trial","volume":"12","author":"Ho","year":"2017","journal-title":"PLoS One"},{"key":"2025121410004173000_10.12.e038455.32","first-page":"863","article-title":"[Efficacy observation of cervical spondylosis treated with acupuncture at three lines of cervical Jiaji (EX-B 2)]","volume":"34","author":"Xie","year":"2014","journal-title":"Zhongguo Zhen Jiu"},{"key":"2025121410004173000_10.12.e038455.33","first-page":"1274","article-title":"[Acupuncture combined with Jingtong granule for nerve-root type cervical spondylosis and its effects on IL-6\u3001TNF-\u03b1\u3001IL-1\u03b2 and hemorheological indexes]","volume":"39","author":"Pan","year":"2019","journal-title":"Zhongguo Zhen Jiu"},{"key":"2025121410004173000_10.12.e038455.34","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s11655-017-2925-7","article-title":"Wet cupping therapy improves local blood perfusion and analgesic effects in patients with nerve-root type cervical spondylosis","volume":"24","author":"Meng","year":"2018","journal-title":"Chin J Integr Med"},{"key":"2025121410004173000_10.12.e038455.35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"2025121410004173000_10.12.e038455.36","unstructured":"Organization WH . International statistical classification of diseases and related health problems: 10th revision (ICD-10), 2020. Available: https:\/\/apps.who.int\/iris\/handle\/10665\/43110?locale=fr"},{"key":"2025121410004173000_10.12.e038455.37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-038455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:00:48Z","timestamp":1765735248000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-038455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,18]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bmjopen-2020-038455"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-038455","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}