{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:50:14Z","timestamp":1782489014987,"version":"3.54.5"},"reference-count":19,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005072","name":"Japanese Circulation Society","doi-asserted-by":"publisher","award":["project for genome analysis in cardiovascular dise"],"award-info":[{"award-number":["project for genome analysis in cardiovascular dise"]}],"id":[{"id":"10.13039\/501100005072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["Research Grant for Research on Rare and Intractabl"],"award-info":[{"award-number":["Research Grant for Research on Rare and Intractabl"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,8,4]]},"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited genetic disease. It carries an extremely high cardiovascular risk associated with significantly elevated low-density lipoprotein (LDL) cholesterol. The diagnostic rate of this disease in some European nations is quite high, due to the presence of multiple prospective registries. On the other hand, few data\u2014and in particular multicentre data\u2014exist regarding this issue among Japanese subjects. Therefore, this study intends to assemble a multicentre registry that aims to comprehensively assess cardiovascular risk among Japanese FH patients while taking into account their genetic backgrounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The Hokuriku-plus FH registry is a prospective, observational, multicentre cohort study, enrolling consecutive FH patients who fulfil the clinical criteria of FH in Japan from 37 participating hospitals mostly in Hokuriku region of Japan from April 2020 to March 2024. A total of 1000 patients will be enrolled into the study, and we plan to follow-up participants over 5 years. We will collect clinical parameters, including lipids, physical findings, genetic backgrounds and clinical events covering atherosclerotic and other important events, such as malignancies. The primary endpoint of this study is new atherosclerotic cardiovascular disease (ASCVD) events. The secondary endpoints are as follows: LDL cholesterol, secondary ASCVD events and the occurrence of other diseases including hypertension, diabetes and malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study is being conducted in compliance with the Declaration of Helsinki, the Ethical Guidelines for Medical and Health Research Involving Human Subjects, and all other applicable laws and guidelines in Japan. This study protocol has been approved by the Institutional Review Board at Kanazawa University. We will disseminate the final results at international conferences and in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>UMIN000038210.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-038623","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T02:33:43Z","timestamp":1599791623000},"page":"e038623","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-1809","authenticated-orcid":false,"given":"Hayato","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Shimojima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-8240","authenticated-orcid":false,"given":"Akihiro","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyonobu","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichiro","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Inazu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Science, Molecular Biochemistry and Molecular Biology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Takahara","sequence":"additional","affiliation":[{"name":"Innovative Clinical Research Center, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Imai","sequence":"additional","affiliation":[{"name":"Innovative Clinical Research Center, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Namura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Terai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Araki","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Saiseikai Kanazawa Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Minamoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, JCHO Kanazawa Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Aburao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, JCHO Kanazawa Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, KKR Hokuriku Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, KKR Hokuriku Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kanazawa-Nishi Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Todo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hokuriku Central Hospital of Japan Mutual Aid Association of Public School Teachers, Oyabe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Suzu City General Hospital, Suzu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wajima City Hospital, Wajima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wajima City Hospital, Wajima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shintaku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wajima City Hospital, Wajima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Hodatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keiju General Hospital, Nanao, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Ino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Houju Memorial Hospital, Nomi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Higashikata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuko","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushi","family":"Misawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaga Medical Center, Kaga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukui Prefectural Hospital, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Noji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukui Prefectural Hospital, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Osato","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukui CardioVascular Center, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukui CardioVascular Center, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Ichise","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukui CardioVascular Center, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunji","family":"Kaku","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Katsuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuharu","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Nakahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Takaoka City Hospital, Takaoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Nozue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Michishita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yokohama Sakae Kyosai Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Usuda","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanichi","family":"Otowa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyasu","family":"Okeie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyama City Hospital, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kurobe City Hospital, Kurobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Aburadani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kurobe City Hospital, Kurobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tonami General Hospital, Tonami, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tonami General Hospital, Tonami, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Hondo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Public Central Hospital of Matto Ishikawa, Hakusan, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Public Central Hospital of Matto Ishikawa, Hakusan, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa City Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa City Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa Arimatsu Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa Red Cross Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiteru","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa Red Cross Hospital, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Omi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikara","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yawata Medical Center, Komatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Katsuki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yawata Medical Center, Komatsu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ootsuji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hakui Public Hospital, Hakui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hakui Public Hospital, Hakui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Noto General Hospital, Nanao, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Okura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Maeno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Mitamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Municipal Tsuruga Hospital, Tsuruga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tsurugi Hospital, Hakusan, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kouseiren Namerikawa Hospital, Namerikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Akao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kanazawa Medical University Hospital, Kahoku-gun, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Kajinami","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kanazawa Medical University Hospital, Kahoku-gun, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masa-aki","family":"Kawashiri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"2026062608014612000_10.9.e038623.1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.5551\/jat.CR003","article-title":"Guidelines for diagnosis and treatment of familial hypercholesterolemia 2017","volume":"25","author":"Harada-Shiba","year":"2018","journal-title":"J Atheroscler Thromb"},{"key":"2026062608014612000_10.9.e038623.2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000297"},{"key":"2026062608014612000_10.9.e038623.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.11.025"},{"key":"2026062608014612000_10.9.e038623.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"2026062608014612000_10.9.e038623.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.11.005"},{"key":"2026062608014612000_10.9.e038623.6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5551\/jat.RV16008","article-title":"Half a century tales of familial hypercholesterolemia (FH) in Japan","volume":"24","author":"Mabuchi","year":"2017","journal-title":"J Atheroscler Thromb"},{"key":"2026062608014612000_10.9.e038623.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2423"},{"key":"2026062608014612000_10.9.e038623.8","doi-asserted-by":"publisher","DOI":"10.5551\/jat.4143"},{"key":"2026062608014612000_10.9.e038623.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.09.002"},{"key":"2026062608014612000_10.9.e038623.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(03)00233-8"},{"key":"2026062608014612000_10.9.e038623.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.12.008"},{"key":"2026062608014612000_10.9.e038623.12","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-94"},{"key":"2026062608014612000_10.9.e038623.13","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jacl.2018.08.006","article-title":"Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease","volume":"12","author":"Tada","year":"2018","journal-title":"J Clin Lipidol"},{"key":"2026062608014612000_10.9.e038623.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"2026062608014612000_10.9.e038623.15","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht273"},{"key":"2026062608014612000_10.9.e038623.16","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/eurheartj\/ehx004","article-title":"Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia","volume":"38","author":"Tada","year":"2017","journal-title":"Eur Heart J"},{"key":"2026062608014612000_10.9.e038623.17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jacl.2017.12.002","article-title":"Assessment of arterial stiffness in patients with familial hypercholesterolemia","volume":"12","author":"Tada","year":"2018","journal-title":"J Clin Lipidol"},{"key":"2026062608014612000_10.9.e038623.18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023636"},{"key":"2026062608014612000_10.9.e038623.19","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1253\/circj.CJ-19-0317","article-title":"Rare and deleterious mutations in ABCG5\/ABCG8 genes contribute to mimicking and worsening of familial hypercholesterolemia phenotype","volume":"83","author":"Tada","year":"2019","journal-title":"Circ J"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-038623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:14:38Z","timestamp":1782486878000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-038623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":19,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,10]]},"published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1136\/bmjopen-2020-038623"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-038623","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}