{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:31:19Z","timestamp":1791491479174,"version":"4.3.4"},"reference-count":30,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"unspecified","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                        <jats:title>Objective<\/jats:title>\n                        <jats:p>To evaluate the safety and efficacy of percutaneous left atrial\n                            appendage occlusion (LAAO) using conscious sedation (CS).<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Several percutaneous structural heart disease interventions are\n                            safely and efficiently performed using CS instead of general anaesthesia\n                            (GA). This concept has not been evaluated in a large multicenter cohort\n                            of patients undergoing LAAO.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Patients from the prospective, global Amplatzer Amulet Occluder\n                            Observational Study were divided into two groups (GA vs CS). Baseline\n                            information, periprocedural and postprocedural efficacy and\n                            complications, as well as outcomes through 7\u2009days post implant were\n                            compared.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Patients undergoing transesophageal-guided implants were categorised\n                            by GA (n=607, 64%) or CS (n=342, 36%) usage. Mean age was 75 years in\n                            both groups. LAAO technical success was achieved in 99% of both groups.\n                            The procedure duration (GA: 35\u00b122\u2009min vs CS: 27\u00b119\u2009min, p&lt;0.001),\n                            total amount of contrast medium (GA: 105\u00b181\u2009mL vs CS: 86\u00b166\u2009mL,\n                            p&lt;0.001) and fluoroscopic time (GA: 13\u00b19\u2009min vs CS: 12\u00b113\u2009min,\n                            p&lt;0.001) were less in CS cases. Procedure-related or device-related\n                            serious adverse events during the first 7\u2009days were numerically higher\n                            in the CS group (GA: 4.9% vs CS: 7.6%, p=0.114). Peridevice residual\n                            flow was absent or \u22645\u2009mm 1\u20133\u2009months after the procedure in 99.7% of the\n                            GA and in 100% of the CS group (p=1.000).<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>In a large global study, LAAO with the Amplatzer Amulet occluder is\n                            safe and feasible using CS. Procedure duration and total amount of\n                            contrast were less with CS than GA cases.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Trial registration number<\/jats:title>\n                        <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02447081\">NCT02447081<\/jats:ext-link>; Results.<\/jats:p>\n                    <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-040455","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T18:07:53Z","timestamp":1616609273000},"page":"e040455","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical outcomes of patients undergoing percutaneous left atrial\n                        appendage occlusion in general anaesthesia or conscious sedation: data from\n                        the prospective global Amplatzer Amulet Occluder Observational Study"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct02447081","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02447081","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-7592","authenticated-orcid":false,"given":"Kerstin","family":"Piayda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Hellhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens 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