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Planned subgroups were incidence by age, sex, race and athletic status (including military personnel).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data extraction<\/jats:title><jats:p>Two reviewers independently assessed study eligibility, extracted study data and assessed risk of bias using the Joanna Briggs Institute critical appraisal checklist for prevalence studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Analysis<\/jats:title><jats:p>Reported incidence of sudden cardiac death in the young per 100\u2009000 person-years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>38 studies that reported incidence across five continents. We identified substantial heterogeneity in population, sudden cardiac death definition, and case ascertainment methods, precluding meta-analysis. Median reported follow-up years was 6.97\u2009million (IQR 2.34 million\u201323.70 million) and number of sudden cardiac death cases was 64 (IQR 40\u2013251). In the general population, the median of reported incidence was 1.7 sudden cardiac death per 100\u2009000 person-years (IQR 1.3\u20132.6, range 0.75\u201311.9). Most studies (n=14, 54%) reported an incidence between one and two cases per 100\u2009000 person-years. Incidence was higher in males and older individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This systematic review identified variability in the reported incidence of sudden cardiac death in the young across studies. Most studies reported an incidence between one and two cases per 100\u2009000 person-years.<\/jats:p><\/jats:sec><jats:sec><jats:title>PROSPERO registration number<\/jats:title><jats:p>CRD42019120563.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2020-040815","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:03:27Z","timestamp":1602144207000},"page":"e040815","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Incidence of sudden cardiac death in the young: a systematic review"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2123-2022","authenticated-orcid":false,"given":"Keith","family":"Couper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Putt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bradlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin D","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Royle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-4758","authenticated-orcid":false,"given":"Joyce","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-4346","authenticated-orcid":false,"given":"Sian","family":"Taylor-Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"2020100801001922000_10.10.e040815.1","unstructured":"World Health Organisation . 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