{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:54:46Z","timestamp":1765781686118,"version":"3.48.0"},"reference-count":16,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"unspecified","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,12,7]]},"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The COVID-19 outbreak has posed a major challenge to healthcare providers. Due to its communicable nature, very stringent public health interventions have been put in place worldwide; yet, it still poses new emerging challenges, one of the most recent being a multisystem inflammatory condition with clinical features resembling Kawasaki-like disease and toxic shock syndrome in children and adolescents. The data on this novel condition are scarce which need to be reported to identify its clinico-epidemiological and geographical distribution. There is an urgent need to generate evidence for diagnosis and management of this condition in the midst of a pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This systematic review will be conducted using Medline database searched through PubMed, Embase, Ovid; and Google Scholar, ProQuest and EBSCO databases will also be searched along with grey literature with the aim to identify the clinical features, aetiopathology, laboratory findings, treatment modes and outcomes of Kawasaki-like disease among paediatric patients suffering from COVID-19. Original articles reporting Kawasaki-like disease in paediatric patients with COVID-19 will be retrieved after screening by two independent reviewers. Data will be extracted in a specially designed form and studies will be assessed independently for risk of bias. Data will be extracted for the following: author, journal title, publication year, study design, study setting, demographic characteristics, sample size, clinical features, aetiopathology, laboratory findings, modes and doses of treatment given, strength and weakness of studies. A descriptive and quantitative analysis will be completed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This is a literature-based review study with no ethical concerns. We will publish the results in a peer-reviewed journal and present at a conference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42020187427.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-041160","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T11:31:50Z","timestamp":1608809510000},"page":"e041160","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Clinico-epidemiological characteristics of Kawasaki-like disease in paediatric patients with COVID-19: a protocol for rapid living systematic review"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7702-3671","authenticated-orcid":false,"given":"Abhinav","family":"Sinha","sequence":"first","affiliation":[{"name":"ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swetalina","family":"Nayak","sequence":"additional","affiliation":[{"name":"ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyadarshini","family":"Dehuri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srikanta","family":"Kanungo","sequence":"additional","affiliation":[{"name":"ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghamitra","family":"Pati","sequence":"additional","affiliation":[{"name":"ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"2025121422504926000_10.12.e041160.1","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.4031","article-title":"Critical care utilization for the COVID-19 outbreak in Lombardy, Italy","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA"},{"key":"2025121422504926000_10.12.e041160.2","doi-asserted-by":"crossref","unstructured":"Gorbalenya AE . Severe acute respiratory syndrome-related coronavirus \u2013 the species and its viruses, a statement of the coronavirus Study Group. bioRxiv 2020.","DOI":"10.1101\/2020.02.07.937862"},{"key":"2025121422504926000_10.12.e041160.3","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.13.2000280","article-title":"Only strict quarantine measures can curb the coronavirus disease (COVID-19) outbreak in Italy, 2020","volume":"25","author":"Sj\u00f6din","year":"2020","journal-title":"Eurosurveillance"},{"key":"2025121422504926000_10.12.e041160.4","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.6130","article-title":"Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China","volume":"323","author":"Pan","year":"2020","journal-title":"JAMA"},{"key":"2025121422504926000_10.12.e041160.5","doi-asserted-by":"crossref","unstructured":"Morand A , Urbina D , Fabre A . COVID-19 and Kawasaki like disease: the known-known, the unknown-known and the unknown, 2020.","DOI":"10.20944\/preprints202005.0160.v1"},{"key":"2025121422504926000_10.12.e041160.6","doi-asserted-by":"crossref","unstructured":"Sandhaus H , Crosby D , Sharma A , et al . Association between COVID-19 and Kawasaki disease: vigilance required from Otolaryngologists. Otolaryngol Neck Surg 2020;019459982093023 http:\/\/journals.sagepub.com\/doi\/","DOI":"10.1177\/0194599820930238"},{"key":"2025121422504926000_10.12.e041160.7","doi-asserted-by":"crossref","unstructured":"Qiu H , Wu J , Hong L , et al . Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis 2020.","DOI":"10.1016\/S1473-3099(20)30198-5"},{"key":"2025121422504926000_10.12.e041160.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"2025121422504926000_10.12.e041160.9","unstructured":"Explained: Inflammatory syndrome in children possibly linked to COVID-19 | Euronews [online]. Available: https:\/\/www.euronews.com\/2020\/05\/24\/coronavirus-what-is-kawasaki-disease-and-its-possible-link-with-covid-19-in-children [Accessed 26 May 2020]."},{"key":"2025121422504926000_10.12.e041160.10","unstructured":"Coronavirus (COVID-19) events as they happen [online]. Available: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/events-as-they-happen [Accessed 26 May 2020]."},{"key":"2025121422504926000_10.12.e041160.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"2025121422504926000_10.12.e041160.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"2025121422504926000_10.12.e041160.13","unstructured":"Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 [online]. Available: https:\/\/www.who.int\/news-room\/commentaries\/detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19 [Accessed 1 Jun 2020]."},{"key":"2025121422504926000_10.12.e041160.14","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"349","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"2025121422504926000_10.12.e041160.15","unstructured":"A rapid living systematic review of clinico-epidemiological characteristics of Kawasaki disease in COVID-19 pediatric patients [online]. Available: https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42020187427 [Accessed 26 May 2020]."},{"key":"2025121422504926000_10.12.e041160.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2020-041160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:51:01Z","timestamp":1765781461000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2020-041160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":16,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,24]]},"published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1136\/bmjopen-2020-041160"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2020-041160","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2020,12]]}}}