{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T14:04:34Z","timestamp":1765893874948,"version":"3.48.0"},"reference-count":76,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["T000216N"],"award-info":[{"award-number":["T000216N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,12,11]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Radical surgery after a total mesorectal excision (TME) for rectal cancer often results in a significant decrease in the patient\u2019s quality of life, due to functional problems such as bowel, urinary and sexual dysfunction. The effect of pelvic floor muscle training (PFMT) on these symptoms has been scarcely investigated. We hypothesise that the proportion of successful patients will be significantly higher in the intervention group, receiving 12 weeks of PFMT, compared with the control group without treatment. The primary outcome of this trial is the severity of bowel symptoms, measured through the Low Anterior Resection Syndrome questionnaire, 4 months after TME or stoma closure. Secondary outcomes are related to other bowel and urinary symptoms, sexual function, physical activity and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This research protocol describes a multicentre single blind prospective, randomised controlled trial. Since January 2017, patients treated for rectal cancer (n=120) are recruited after TME in three Belgian centres. One month following surgery or, in case of a temporary ileostomy, 1 month after stoma closure, patients are randomly assigned to the intervention group (n=60) or to the control group (n=60). The assessments concern the preoperative period and 1, 4, 6, 12 and 24 months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study will be conducted in accordance with the Declaration of Helsinki. Ethics approval was granted by the local Ethical Committee of the University Hospitals Leuven (s59761) and positive advice from the others centres has been obtained. Dissemination of the results will be accomplished via guidelines and (non-)scientific literature for professionals as well as organisation of patient symposia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NTR6383.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-041797","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T14:54:10Z","timestamp":1611327250000},"page":"e041797","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Randomised controlled trial to assess efficacy of pelvic floor muscle training on bowel symptoms after low anterior resection for rectal cancer: study protocol"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-5993","authenticated-orcid":false,"given":"Anne","family":"Asnong","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"D\"Hoore","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Vlaams-Brabant, Belgium"},{"name":"Department of Oncology, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke","family":"Van Kampen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Devoogdt","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"De Groef","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Sterckx","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Lemkens","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Wolthuis","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Vlaams-Brabant, Belgium"},{"name":"Department of Oncology, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Van Molhem","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, OLVZ, Aalst, Oost-Vlaanderen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Van Geluwe","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Vlaams-Brabant, Belgium"},{"name":"Department of Abdominal Surgery, AZ Groeninge - Campus Kennedylaan, Kortrijk, West-Vlaanderen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Debrun","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, KU Leuven University Hospitals Leuven Gasthuisberg Campus, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Geraerts","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven, Leuven, Vlaams-Brabant, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"2025121605595534000_11.1.e041797.1","unstructured":"Ferlay JEM , Lam F , Colombet M . 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