{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:12:24Z","timestamp":1760818344731,"version":"build-2065373602"},"reference-count":38,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Lennander\u2019s Foundation","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Swedish research concil for Sport Science","award":["P2019-0011 and D2019-0005"],"award-info":[{"award-number":["P2019-0011 and D2019-0005"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,12,14]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>People with anterior cruciate ligament (ACL) reconstruction (ACLR) are at high risk of sustaining a graft rupture and\/or contra-lateral ACL injury. The main factors that may predispose individuals for subsequent ACL injuries are, however, not established. To reduce the risk of reinjuries, it is of particular interest to identify modifiable risk-factors, for instance, those related to sensorimotor control which are responsive to training. The aim of the current study protocol is to present the design of our prospective cohort study STOP Graft Rupture investigating sensorimotor function as predictors for graft rupture, contra-lateral ACL injury and\/or failure to return to sport (RTS) within 3\u2009years following ACLR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>We aim to recruit 200 individuals (15\u201335 years, ~50% women) with ACLR from Norrland University Hospital, Ume\u00e5 and Lund University Hospital, Lund, Sweden. Participants will be assessed with a comprehensive test battery for sensorimotor muscle function, including hop performance, muscle strength, muscle activation, hip and ankle range of motion and postural orientation as well as patient-reported function 1\u2009year after ACLR (baseline). For a subgroup of individuals (Ume\u00e5 cohort), 3D kinematics and joint position sense will also be evaluated. At follow-up (\u22653 years post-ACLR), the participants will be asked to answer questions related to new ACL injuries to either knee and about RTS. Separate logistic regression models, adjusting for possible confounders, will be used to evaluate the influence of the different sensorimotor predictors on the prospective outcomes (graft rupture, contra-lateral ACL injury, RTS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>This study was approved by the Swedish Ethical Review Board (Dnr 2016\/319 and Dnr 2019-04037). The results will be published in international peer-reviewed scientific journals and presented at clinical and scientific congresses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial pre-results\" xlink:href=\"NCT04162613\">NCT04162613<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-042031","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T15:55:36Z","timestamp":1610121336000},"page":"e042031","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Does sensorimotor function predict graft rupture, contra-lateral injury or failure to return to sports after ACL reconstruction? A protocol for the STOP Graft Rupture study"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct04162613","registry":"10.18810\/clinical-trials-gov","type":"preResults"},{"clinical-trial-number":"nct03473873","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-6320","authenticated-orcid":false,"given":"Anna","family":"Cronstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Community Medicine and Rehabilitation, Ume\u00e5 Universitet, Ume\u00e5, Sweden"},{"name":"Department of Health Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ageberg","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte K","family":"H\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Rehabilitation, Ume\u00e5 Universitet, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"2025101812452586000_11.1.e042031.1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12212"},{"key":"2025101812452586000_11.1.e042031.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.02.021"},{"key":"2025101812452586000_11.1.e042031.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.24066"},{"key":"2025101812452586000_11.1.e042031.4","first-page":"e501","article-title":"Anterior cruciate ligament injury after more than 20 years. 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