{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:03:38Z","timestamp":1773281018173,"version":"3.50.1"},"reference-count":25,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2020,10,23]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0\u201381.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51\u201371); 74.1% men; median length of stay 9 days (IQR 5\u201319)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296\/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702\/361), with the number of patients in ICU quadrupling its capacity (32\/8). Median length of stay was 9 days (IQR 6\u201314).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2020-042398","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T16:50:21Z","timestamp":1605027021000},"page":"e042398","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1553-406X","authenticated-orcid":false,"given":"Eva","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Font\u00e1n-Vela","sequence":"additional","affiliation":[{"name":"Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Valencia","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Fernandez-Jimenez","sequence":"additional","affiliation":[{"name":"Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Alba","family":"\u00c1lvaro-Alonso","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Izquierdo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lazaro Cebas","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Gallego Ruiz-Elvira","sequence":"additional","affiliation":[{"name":"Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Troya","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Josefa","family":"Tebar-Martinez","sequence":"additional","affiliation":[{"name":"Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Garcia-Marina","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Pe\u00f1a-Lillo","sequence":"additional","affiliation":[{"name":"Emergency Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane","family":"Abad-Motos","sequence":"additional","affiliation":[{"name":"Anesthesiology Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Macaya","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Ryan","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-2878","authenticated-orcid":false,"given":"Mario","family":"P\u00e9rez-Butrague\u00f1o","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Hospital Universitario Infanta Leonor, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"2025121410285356000_10.11.e042398.1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2","volume":"5","year":"2020","journal-title":"Nat Microbiol"},{"key":"2025121410285356000_10.11.e042398.2","unstructured":". 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