{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:42:26Z","timestamp":1787938946444,"version":"build-2784847793"},"reference-count":46,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"unspecified","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Growing Games Program","award":["grant number CB00018"],"award-info":[{"award-number":["grant number CB00018"]}]},{"name":"CZ Fund","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2021,3,4]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Distal radius fractures are among the most prevalent traumatic injuries worldwide. These injuries are associated with high healthcare-related and socioeconomic costs, mainly resulting from loss of productivity. To optimise recovery and return to work, wrist exercises are recommended. However, adherence to standard exercise regimens is low. Serious games provide a treatment platform for standardised postoperative care, uniting meaningful recovery with entertainment. Also, mobile serious games, for example, smartphone or tablet applications, are able to send practice reminders believed to improve self-efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>To test the effectiveness of a mobile serious game for distal radius fracture rehabilitation compared with standard care, a multicentre, randomised controlled clinical trial was designed. Primary outcome will be the Patient-Rated Wrist Evaluation (PRWE) score after 6\u2009weeks of treatment. Secondary outcomes are range of motion, grip strength, pain scores, and self-reported treatment adherence after 2, 6 and 12 weeks of treatment.<\/jats:p><jats:p>Adult patients with any type of closed distal radius fracture are included directly after non-operative or operative fracture treatment. Patients are recruited in the outpatient clinics of four teaching hospitals. The intended sample size is 92 patients, based on the minimal clinically important difference of the PRWE score at 6\u2009weeks, using a superiority model.<\/jats:p><jats:p>Patients are randomised between using the wearable-controlled mobile serious game<jats:italic>ReValidate!<\/jats:italic>(intervention group) and standard care consisting of unsupervised exercises and a referral for physiotherapy or exercise therapy upon request or recommendation by the treating clinician (control group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The protocol has been approved by the Medical Ethical Review Board of the Amsterdam University Medical Centres, location Academic Medical Centre in Amsterdam, the Netherlands. Results will be made available to involved healthcare providers, funders, and to the general public including patients via peer-reviewed academic journals and international conferences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p>Dutch Trial Registry (NTR), NL6140, protocol V.2.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2020-042629","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T17:05:40Z","timestamp":1617123940000},"page":"e042629","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Serious game versus standard care for rehabilitation after distal radius fractures: a protocol for a multicentre randomised controlled trial"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-9446","authenticated-orcid":false,"given":"Henri\u00ebtte A W","family":"Meijer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurits","family":"Graafland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miryam C","family":"Obdeijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"van Dieren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Carel","family":"Goslings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-0116","authenticated-orcid":false,"given":"Marlies P","family":"Schijven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"2024101904560678000_11.3.e042629.1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1302\/0301-620X.96B7.33149","article-title":"The operative treatment of fractures of the distal radius is increasing: results from a nationwide Swedish study","volume":"96-B","author":"Mellstrand-Navarro","year":"2014","journal-title":"Bone Joint J"},{"key":"2024101904560678000_11.3.e042629.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2006.04.130"},{"key":"2024101904560678000_11.3.e042629.3","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090523"},{"key":"2024101904560678000_11.3.e042629.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.hcl.2012.02.001"},{"key":"2024101904560678000_11.3.e042629.5","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000312"},{"key":"2024101904560678000_11.3.e042629.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jht.2016.03.003"},{"key":"2024101904560678000_11.3.e042629.7","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2001.26322"},{"key":"2024101904560678000_11.3.e042629.8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-8-48"},{"key":"2024101904560678000_11.3.e042629.9","first-page":"974","article-title":"Epidemiology of distal radius fractures in a geographically defined adult population","volume":"43","author":"Stirling","year":"2018","journal-title":"Journal of Hand Surgery"},{"key":"2024101904560678000_11.3.e042629.10","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(93)90024-A"},{"key":"2024101904560678000_11.3.e042629.11","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00561"},{"key":"2024101904560678000_11.3.e042629.12","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000024662.32024.e3"},{"key":"2024101904560678000_11.3.e042629.13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3111\/13696998.2012.737391","article-title":"The direct and indirect costs of long bone fractures in a working age US population","volume":"16","author":"Bonafede","year":"2013","journal-title":"J Med Econ"},{"key":"2024101904560678000_11.3.e042629.14","unstructured":"Fricker R , Jupiter J , Kastelec M . 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